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The US Food and Drug Administration approved a drug to return sexual desire to some women with low libido, the agency said Friday.The drug, bremelanotide, sold under the brand name Vyleesi by AMAG Pharmaceuticals, is an injection to be taken before sex. It's intended to treat women who are premenopausal and have hypoactive sexual desire disorder, where a lack of interest in sex may cause significant distress in a woman's life.It will be available in September, and the company has not yet determined pricing or reimbursement information, according to AMAG spokeswoman Sarah Connors."Most women who come into my office have no idea that there's this condition ... and that they are one of millions," said Sheryl Kingsberg, division chief of Behavioral Medicine at University Hospitals Cleveland Medical Center. Kingsberg was involved in the drug's clinical trials and has served as a paid consultant for the companies responsible for its marketing and development, AMAG and Palatin Technologies.Kingsberg, a clinical psychologist, said that "the impact of sexual dysfunction on a woman's self-esteem, on her body image, on her self-confidence and on her relationship is profound."Experts say the diagnosis is the most common type of sexual dysfunction among women, estimated to affect between 1308

Toyota is recalling nearly 700,000 vehicles in the U.S. because the fuel pumps can fail and cause engines to stall. That can increase the risk of a crash.The recall covers certain 2018 and 2019 Lexus LS 500, LC 500, RC 350, RC 300, GS 350, IS 300, ES 350, LX 570, GX 460, and RX 350 models. Also included are certain 2018 and 2019 Toyota 4Runner, Camry, Highlander, Land Cruiser, Sequoia, Sienna, Tacoma, and Tundra models. Some 2019 models also are affected including the Avalon and Corolla.Toyota is still developing repairs. Owners will be notified by mail in mid-March. 585

The Seattle mayor has banned the police use of tear gas as protests continue in the city and nationally over the killing of George Floyd. Mayor Jenny Durkan said in a news conference Friday afternoon that the ban would continue for 30 days. The move came hours after three civilian police watchdog groups urged city leaders to do so. Police Chief Carmen Best said: “After hearing concerns about the use of CS gas for crowd control purposes earlier this week, we decided we were going to suspend its use for 30 days." She says during the 30 days officials will review police crowd control policies. 609

The top US general overseeing military operations in the Middle East warned Thursday that despite the terror group's territorial losses the fight against ISIS is "far from over," cautioning that the remnants of the group are positioning themselves for a potential resurgence."Reduction of the physical caliphate is a monumental military accomplishment but the fight against ISIS and violent extremism is far from over," Gen. Joseph Votel the commander of US Central Command told the House Armed Services Committee.Votel acknowledged that the terror group's territory had shrunk from some 34,000 square miles at the height of its power to an area that is currently less than a single square mile in the Syrian town of Baghouz.But he cautioned that many ISIS fighters have left these last pockets and have dispersed across Syria and Iraq."We will need to maintain a vigilant offensive against this now widely dispersed and disaggregated organization that includes leaders, fighters, facilitators, resources and of course their toxic ideology," he said.And while hundreds of family members of ISIS fighters have left the group's last remaining pocket and surrendered to the US-backed Syrian Democratic Forces, Votel warned that this was a "calculated move" aimed at preserving the group's ability to fight in the future."What we are seeing now is not the surrender of ISIS as an organization but a calculated decision to preserve the safety of their families and the preservation of their capabilities by taking their chances in camps for internally displaced persons and going to ground in remote areas and waiting for the right time to resurge," Votel said."The ISIS population being evacuated from the remaining vestiges of the caliphate largely remains unrepentant, unbroken and radicalized," he added, citing observations from US troops on the ground in Syria.Votel went on to describe what the next phase of the fight against ISIS will look like, saying "we will see low level attacks, we'll see assassinations, we'll see IED attacks, we'll see ambush type things as they begin to emerge from this."While President Donald Trump had initially announced his intent to fully withdraw US troops from Syria, he has since 2231

The show will not go on at The Metropolitan Opera for Plácido Domingo.The opera star will not be performing his role as Macbeth in the Met's production of the Giuseppe Verdi classic and will not perform any production at the venue again, bringing to an end a professional relationship that began in 1968, according to statements shared with CNN."The Metropolitan Opera confirms that Plácido Domingo has agreed to withdraw from all future performances at the Met, effective immediately," the statement from a Met spokesperson said. "The Met and Mr. Domingo are in agreement that he needed to step down. The Met has no further comment at this time."Domingo's image was removed from the "Macbeth" page on the Met Opera's official website at roughly 6 p.m. ET. "Macbeth" was set to open Wednesday with Domingo in the lead role.He was set to perform September 25, 28 and October 1. He was also set to perform four dates November in "Madama Butterfly.""While I strongly dispute recent allegations made about me, and I am concerned about a climate in which people are condemned without due process, upon reflection, I believe that my appearance in this production of Macbeth would distract from the hard work of my colleagues both on stage and behind the scenes," Domingo added in a statement. "As a result, I have asked to withdraw and I thank the leadership of the Met for graciously granting my request."He added: "I am happy that, at the age of 78, I was able to sing the wonderful title role in the dress rehearsal of 'Macbeth,' which I consider my last performance on the Met stage. I am grateful to God and the public for what they have allowed me to accomplish here at The Metropolitan opera."Domingo's decision comes as he faces multiple accusations of sexual misconduct, which he has disputed and said were "riddled with inconsistencies."In August, The Associated Press reported that nine women detailed alleged incidents of sexual harassment that took place over three decades beginning in the late 1980s. In September, 11 more people came forward with allegations that included verbal harassment and groping.CNN was unable to verify their accounts."Due to an ongoing investigation, we will not comment on specifics, but we strongly dispute the misleading picture that the AP is attempting to paint of Mr. Domingo," Nancy Seltzer, a spokesperson for Domingo, told CNN in a statement in September.Domingo, 78, is regarded as one of the greatest opera singers of all time. He's won 14 Grammy and Latin Grammy Awards and performed with fellow tenors Luciano Pavarotti and José Carreras as part of the Three Tenors.He made his debut at the Metropolitan Opera at 27 and performed there for 51 consecutive years. 2722