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As we're all focused on the current rollout of the COVID-19 vaccine, a technology known as thin-film freezing is getting a lot of attention. It's groundbreaking and could change the way we administer drugs or use medicine in general.You've probably heard about the need to keep the COVID-19 vaccine cold. It has to be so cold, in fact, that the shipment and transport are challenging. Well, what if that vaccine could be turned into powder?“What we’ve most recently been working on is the elimination of cold chain by storing as a powder, a dry powder where the drug is much more stable than if it was stored as a liquid or as a frozen liquid,” said co-inventor Dr. Robert Williams.Williams said it would eliminate the need for extreme cold storage and transport. The technology isn't new. He got a research grant and came up with it about 15 years ago.Williams, who is also a pharmacy professor at the University of Texas in Austin, said they were working on the technology and its multiple uses when the pandemic hit. And all of a sudden, they got a lot of attention.“We have published over 70 papers on the technology and using it for different products- it’s quite a mature process," Williams said. "We developed it because with other vaccines, the majority of the vaccine cost is in wastage because of this cold chain issue, so we published several key papers where we showed our thin-film freezing technology would protect vaccines - and you wouldn’t need cold chain storage.”Glenn Mattes, President, and CEO of TFF Pharmaceuticals added that the powders can be converted to topical preparations and they are currently working with the US Army to take some of the preparations and would then administer them directly through the eye.TFF is launching thin-film freezing into development through the FDA process. “I use the term ubiquitous because it is and disruptive because it is,” Mattes said. He added that they've explored their technology in the cannabinoid realm. But, as for the COVID vaccine, they're aiming for a second-generation usage.“To truly eradicate the pandemic, you have to have a global response," Mattes said. "The companies we’ve been speaking to certainly recognize the broad utilization of the technology but the application to the developing world, rural area, remote areas, where you can take a powder and inhale it or take the powder and reconstitute it has tremendous potential."Experts say it is only just the beginning as they launch their technology into a new world. 2511

BAKERSFIELD, Calif. (KGTV) — A man accused of boarding a Greyhound bus in San Diego before opening fire and killing one person in the Los Angeles area pleaded not guilty in court.Anthony Devonte Williams, 33, of Capital Heights, Md., pleaded not guilty to one count of first-degree murder and five counts of attempted murder.Williams is accused of opening fire on a bus as it was traveling on Interstate 5 between Los Angeles and Bakersfield on Feb. 3. He reportedly first boarded a bus from San Diego to Los Angeles before boarding another bus in Los Angeles heading to San Francisco.Passengers say Williams was cursing and muttering incoherently before opening fire.The shooting killed 51-year-old Lurbis Elena Vence, of Molino, Colombia, according to KERO., and injured five other people.Other passengers were able to disarm Williams and forced him off the bus. 872

Authorities have removed 23 passengers from a Carnival Cruise Line ship in Australia after a series of brawls, New South Wales police and Carnival said in statements.Cellphone video from the ship shows passengers tussling with each other, and with security officers, outside a nightclub and by a swimming pool amid shouting and screams from alarmed onlookers.Carnival said police on Friday removed "a large family group who had been involved in disruptive acts aboard Carnival Legend. Our security team responded in several instances to extremely unruly behavior by these guests. One particular altercation in the nightclub began when the group physically attacked other guests."Police said they were told several men fought in the early morning hours Friday while the ship was about 220 kilometers (137 miles) off Jervis Bay. Security officers on the ship intervened and detained the men before notifying police, police said.  940

As the holiday season approaches, many companies are in need of temporary employees. Although these jobs are generally considered temporary, some retailers say jobs positions could lead into permanent positions. Here is a look at who is hiring:Best BuyElectronic retailer Best Buy said it will hire an unspecified number of temporary employees for the holidays. The company will host job fairs in nearly a dozen cities on Oct. 10. Also, the retailer will have on-site job interviews on Oct. 10 and 11 nationwide. To reserve a spot for an interview, click here. Best Buy said that 30 percent of its full-time employees began as seasonal workers.Dick's Sporting GoodsTaking a page from the sports world, Dick’s Sporting Goods is hosting a “National Signing Day” on October 16 to fill 8,000 positions nationwide. Dick’s said applicants are encouraged to first apply online at dicks.com/jobs,GapGap has more than 2,000 seasonal positions for this year. To apply, click here.Kohl's Kohl's said it plans to hire 90,000 seasonal employees this year. Kohl's said positions are available at 11,000 locations nationwide. For more info, click here. Macy'sMacy's said it plans to hire 80,000 seasonal employees this year. Among the more interesting opportunities, the company plans to hire 1,000 people to assist with the company's Thanksgiving Day parade. Macy's also said its hosting on-site interviews on Thursday, October 24, 2019, from 11 a.m. – 7 p.m. For more info, click here.The company said that in 2018, 8,000 seasonal employees became permanent workers.RadialLooking for a more behind the scenes position? Radial is looking to hire 21,000 seasonal employees for the holidays. Radial provides fulfillment and customer care services for retailers nationwide. For more info, click here.TargetTarget will do two rounds of job fairs for potential employees. The first round of job interviews will be from Oct. 11 to 13 and the second from Nov. 2 to 3. Target plans to hire more than 130,000 seasonal employees. Target says that minimum pay for employees will be . For more information, click here. UPS UPS said it plans on hiring 100,000 people for the holidays. UPS says that nearly one third of its workforce started as seasonal employees. The majority of positions are for package handlers, drivers and driver-helpers. For more info, click here. 1-800 Flowers1-800 Flowers said it plans to hire 8,000 seasonal employees. For details, click here. 2454

Attorney General William Barr took aim at his own Justice Department on Wednesday, criticizing prosecutors for behaving as “headhunters” in their pursuit of prominent targets and politically charged cases.The comments at a speech at Hillsdale College in Michigan amount to a striking and unusual rebuke of the thousands of prosecutors who do the daily work of assembling criminal cases across the country.Barr described the prosecutors as part of the “permanent bureaucracy” and said they were in need of supervision from “detached,” politically appointed leaders who are accountable to the president and Congress.“The men and women who have ultimate authority in the Justice Department are thus the ones on whom our elected officials have conferred that responsibility — by presidential appointment and Senate confirmation,” Barr said, according to his prepared remarks. “That blessing by the two political branches of government gives these officials democratic legitimacy that career officials simply do not possess.”As Attorney General, Barr has been aggressive in pursuing certain categories of prosecution himself, including seeking federal charges against those arrested in protests following the death of George Floyd. In fact, later on Wednesday, Barr said wants prosecutors to be aggressive in charging demonstrators who cause violence.So far, more than 300 people have been charged with federal crimes in the protests that erupted following the death of George Floyd.An Associated Press analysis shows that many are accused of serious crimes like hurling Molotov cocktails, burning police cars and seriously injuring law enforcement. Others are not accused of serious crimes, prompting criticism that the effort is a politically motivated effort to stymie demonstrations. 1790

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