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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

The year 2018 was a tale of two stories: a year of record-breaking holiday sales and a year of retailers filing for bankruptcy. According to the Mastercard Spending Pulse report, brick and mortar stores saw a 5 percent increase in sales compared to last year. There was a 19 percent increase for online sales. However, it was also year big retailers like Sears filed for bankruptcy, and Toys-R-Us closed its stores. “Weak retailers are closing,” says marketing professor Darrin Duber-Smith. “It just takes them forever to close.” What does this mean for retailers as we head into 2019? “If the retailers that are in trouble--the ones that are kind of running out of cash, the ones that really look like they're going out of business--if they don't have a good holiday season, they're pretty much dead in the water in the first couple of quarters,” Duber-Smith explains. Despite an increase in holiday sales overall, department stores struggled. Sales were reportedly down 1.3 percent this holiday season. J.C. Penny’s stock fell below a share for the first time last week. Lord & Taylor and Saks Fifth Avenue have been shutting down some of their flagship stores, and Nieman Marcus has big debt coming due in 2020 and 2021. Duber-Smith says debt is a make or break. “These brands that are saddled with so much debt aren't able to invest in their companies,” he explains. “They're not able to invest in marketing. They're not able to invest in e-commerce.” E-commerce is key. Online sales growth for department stores grew 10.2 percent, but Amazon is still king when it comes to online retailers. That's why some stores have decided to work with the retail giant. “Best Buy was left for dead,” Duber-Smith explains. “Now, they have a partnership with Amazon where you can try the products in-store and buy it on Amazon. But now, Best Buy get a piece of that action.”Survival for some retailers means finding creative ways to thrive in an ever-changing retail landscape. 1990

Timmothy Pitzen's family, still grappling with the child's disappearance and his mother's suicide, just suffered a painful roller coaster of emotions — all because of an imposter's prank.Why did this happen? And where does the search for Timmothy go now?As more details emerge, many questions linger. But there's one silver lining to this hoax that has gripped the country.Why did a man claim to be Timmothy? When Brian Michael Rini drifted into a Kentucky neighborhood claiming to be Timmothy, he ignited hope that the boy, who vanished at age 6 after his mother killed herself, was found alive and well after almost eight years.But a DNA test showed Rini was an imposter. Now he faces charges of making false statements to federal agents and could face up to eight years in prison.Rini has a history of using other people's identities, his brother Jonathon said.The suspect learned about Timmothy's case after watching a story about him on ABC's "20/20," according to a criminal complaint and affidavit.The affidavit also said Rini "wanted to get away from his own family. When questioned further, Rini stated he wished he had a father like Timmothy's because if he went missing, his father would just keep drinking."Why would someone claim to be a missing child?Jonathon Rini told CNN's "New Day" that his brother had been diagnosed with Asperger's syndrome and bipolar disorder. "Still, he should have the rational thinking to not do something like this," he said.What happens to the search for Timmothy now? It'll keep going, but authorities are back to square one in trying to figure out where Timmothy is."To be clear, law enforcement has not and will not forget Timmothy, and we hope to one day reunite him with his family," the 1748

The Top US diplomat in Ukraine Bill Taylor testified Tuesday that he had been told President Donald Trump would withhold military aid to the country until it publicly declared investigations would be launched that could help his reelection chances — including into former Vice President Joe Biden, according to a copy of Taylor's opening statement obtained by CNN."During that phone call, Ambassador Sondland told me that President Trump had told him that he wants President Zelensky to state publicly that Ukraine will investigate Burisma and alleged Ukrainian interference in the 2016 US election," according to the testimony.Sondland told Taylor he'd also made a mistake earlier by telling the Ukrainian officials that a White House meeting with Zelensky "was dependent on a public announcement of the investigations," Taylor said."In fact, Ambassador Sondland said, 'everything' was dependent on such an announcement, including security assistance," Taylor testified.He testified that Trump wanted Zelensky "in a public box" by making a public statement about ordering the investigations."Ambassador Sondland tried to explain to me that President Trump is a businessman. When a businessman is about to sign a check to someone who owes him something, he said, the businessman asks that person to pay up before signing the check," Taylor testified, adding that Volker had used the same phrase."I argued to both that the explanation made no sense: the Ukrainians did not 'owe' President Trump anything, and holding up security assistance for domestic political gain was 'crazy,' as I had said in my text message to Ambassadors Sondland and Volker on September 9," Sondland added.Democrats described Taylor's testimony as damning for the President."All I have to say is that in my 10 short months in Congress ... it's my most disturbing day in Congress so far," said Rep. Andy Levin, a freshman Democrat from Michigan."This testimony is a sea change. I think it could accelerate matters," said Democratic Rep. Stephen Lynch of Massachusetts. "This will, I think, answer more questions than it raises. Let's put it that way."In a lengthy and detailed opening statement, Taylor said that he and Sondland spoke by phone about why the aid was frozen, and Sondland cited the need for Ukraine to open an investigation among other reasons, according to the sources. Sondland told Taylor that the investigations potentially included both Ukraine's involvement in the 2016 election and Burisma, the Ukrainian energy company that hired former Vice President Joe Biden's son Hunter Biden, the sources said.Asked about Taylor's comments, a source familiar with Sondland's testimony said that Sondland cited, in addition to the investigations, that the aid may have been frozen because the Europeans weren't giving Ukraine enough and corruption in general. The source said Sondland was only speculating when he referenced the political investigations into the 2016 election and Burisma."He made very clear in his testimony that nobody would give him a straight answer" about why the aid was being held up, the source said about Sondland's testimony. 3148

Three people were arrested and eight people injured, including at least three police officers, during violent demonstrations in Portland on Saturday, according to police.Multiple assaults were reported, police said, and items were thrown at demonstrators and officers that looked like milkshakes but contained quick-dry concrete.Portland Fire & Rescue medics treated eight people on the scene, authorities said, including three police officers.Two officers were pepper sprayed, an officer was punched in the arm by a demonstrator, and an officer sustained a head injury from a projectile, police said. The injuries were not life-threatening.According to CNN Portland affiliates 694