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WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

BEIJING, Jan. 31 (Xinhua) -- Senior Chinese leader Li Changchun Monday visited performers and producers of China Central Television's Spring Festival gala during their rehearsal.Li, a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, extended new year greetings to the crew.Li Changchun (front R), a member of the Standing Committee of the Political Bureau of the Communist Party of China (CPC) Central Committee, shakes hands with actors at the rehearsal of the Spring Festival Gala Evening at China Central Television (CCTV) in Beijing, China, Jan. 31, 2011. He hoped an excellent show will be presented on the eve of the Spring Festival, or Lunar New Year, which falls on Feb. 3.The annual Lunar New Year gala celebration started in the 1980s. Since then, it has been the most popular TV event, attracting a major portion of China's 1.3 billion population each year.

TOKYO, Feb. 6 (Xinhua) -- Japanese Prime Minister Naoto Kan said Sunday that Japan is ready to reconstruct relations with China in cultural, economic, political and other areas, the Jiji Press reported."This year marks the 100th anniversary of China's Revolution of 1911, and next year will be the 40th anniversary of the normalization of Sino-Japanese relations," said Kan at the first session of the "China-issue" advisory committee, organized by the Japanese government and attended by personages from economic, cultural and academic circles."On this special occasion," Kan said, "Japan is ready to rebuild relations with China in various areas such as culture, economic and politics."According to local media reports, participants at the meeting put forward suggestions such as "China is a promising market in the economic area, and ties with China are thus of great importance" and "people-to-people exchanges need to be promoted in areas of culture, sports and arts."The committee is scheduled to submit the final advisory report to the government in mid-April.

BEIJING, April 14 (Xinhuanet) -- The discovery of a sharp-toothed dinosaur fossil in New Mexico, the United States, may bridge a gap in the evolution of the species, researchers said in Wednesday's journal Proceedings of the Royal Society B.Researchers from the Smithsonian Institution unearthed the dinosaur skull and neck vertebrae in Abiquiu, New Mexico, where it had remained buried for around 230 million years. The short snout and slanting front teeth of the find — Daemonosaurus chauliodus — had never before been seen in a Triassic era dinosaur, said Hans-Dieter Sues of the Smithsonian's National Museum of Natural History.Sues, curator of vertebrate paleontology at the museum, said the discovery helps fill the evolutionary gap between the dinosaurs that lived in what is now Argentina and Brazil about 230 million years ago and the later theropods like the famous Tyrannosaurus rex."Various features of the skull and neck in Daemonosaurus indicate that it was intermediate between the earliest known predatory dinosaurs from South America and more advanced theropod dinosaurs," said Sues."One such feature is the presence of cavities on some of the neck vertebrae related to the structure of the respiratory system," he added.The discovery suggests that there is still much to be learned about the early evolution of dinosaurs."The continued exploration of even well-studied regions like the American Southwest will still yield remarkable new fossil finds," Sues said.

LOS ANGELES, May 29 (Xinhua) -- Nineteen percent of