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Researchers published what they say is the first case of a living person diagnosed with the degenerative brain disease chronic traumatic encephalopathy or CTE.While unnamed in the study, lead author Dr. Bennet Omalu confirmed to CNN that the subject of the case was former NFL player Fred McNeill -- who died in 2015.Omalu is credited with first discovering CTE in professional football players. Until now, the only way to diagnose the disease is with a brain exam after death.The diagnosis was first made using an experimental brain scan that can trace a signature protein of CTE called tau. The authors then confirmed the diagnosis with an autopsy. The case study was published in the journal Neurosurgery this week.'It looked like just depression'Omalu first presented these findings exclusively to CNN's chief medical correspondent, Dr. Sanjay Gupta, in 2016. McNeill's wife, Tia, and his two sons, Gavin and Fred Jr., told Gupta then that they saw Fred transform from a fun loving family man at the center of their lives into a man who was dealing with symptoms of memory loss, anger and depression that tore their family apart."There are some times where the father is the stronghold in the family, or the anchor. If you lose that, everything kind of falls apart. That's kind of what happened for us. It looked like financial issues at first; it looked like marital issues, and they separated; then it looked like just depression," Gavin told Gupta.CTE is known for plaguing people with Alzheimer's like symptoms such as memory loss, rage, mood swings, and in some cases, suicidal ideation.Severity of the disease is categorized into four stages, with stage 4 being the most severe. While researchers don't know exactly why certain people develop the disease and others don't, they believe that it results from repeated blows to the head that trigger a build up of tau proteins in the brain.CTE has been called football's "concussion crisis," however experts point out that CTE can develop from any repeated head injury. According to the Boston University CTE Center, "this trauma includes both concussions that cause symptoms and subconcussive hits to the head that cause no symptoms." These subconcussive hits can include the repeated trauma the brain experiences from constant plays, hitting the turf, and tackling. Wrestlers, boxers, and military troops have also been diagnosed with the disease.Seeing CTEWhile McNeill is the first case to be confirmed with an autopsy, the experimental technology has been used on at least a dozen other former NFL players, including Pro Football Hall of Famer, Dallas Cowboy Tony Dorsett. Omalu helped develop and is invested in the diagnostic exam, which uses a radioactive "tracer" called FDDNP to bind to tau proteins in the brain. The tau proteins can then be seen on a PET scan of the brain.Critics have said the protein also can highlight another protein called amyloid, which may be indicative of Alzheimer's or other forms of dementia. But Omalu noted that in CTE, tau makes distinctive patterns in the brain. It has a "specific topographic signature," he said, and that pattern can be detected in imaging.Omalu said he and his team are currently raising money to start a phase 3 clinical trial to further test the technology and replicate what they have seen in McNeill. He anticipates that once funds are raised, it will take another two to three years for the trial and then another year, at least, for approval from the US Food and Drug Administration. When asked, how soon a commercial test could be available, Omalu predicted it could be as soon as a few years. "We are looking at less than five years," he said.  3711

Raise your hand if you know someone who has moved to Atlanta, Dallas-Fort Worth or Houston recently. A lot of hands went up, because those are the three fastest-growing metropolitan areas — and they have relatively affordable home prices, too.Each quarter, NerdWallet calculates home affordability for 172 metro areas. NerdWallet narrowed its focus this quarter to the 10 metros that had the most population growth from mid-2016 to mid-2017, the latest data available from the U.S. Census Bureau. Among these 10, Atlanta had the most affordable home prices this spring and Seattle had the least affordable.The top three metros on this list have two things in common, says Danielle Hale, chief economist for Realtor.com: They have space to grow, with few physical barriers such as mountains and oceans, and they have local governments that “are more willing to permit and allow development, too.”Affordability was calculated by comparing incomes and median home prices. A place with high incomes and low home prices is more affordable than an area with low incomes and high home prices.Here are the 10 fastest-growing metro areas, ranked from most to least affordable for buying a home in the second quarter of 2018. The rankings were compiled using data from the National Association of Realtors, the U.S. Census Bureau and NerdWallet surveys.? MORE: How much home can you afford in your area? 1416

Republican and Democratic Senate leaders reached a broad deal Thursday to confirm a package of 15 judges that will allow the senators to depart Washington until after Election Day.Senate Majority Leader Mitch McConnell made the agreement public when he announced votes on three circuit court judges and 12 district court judges.The deal is a significant victory for McConnell, who has made clearing a long list of President Donald Trump's nominees, especially judges, a top priority this year.It is also a boon for senators seeking re-election, especially those 10 Democrats running in states won by Trump in 2016, because they will be free finally to leave DC and focus more fully for the next month on their campaigns.Republican leaders made clear throughout the year they had no qualms about keeping senators in Washington until very close to Election Day. That's because the GOP is defending only eight Senate seats in November, only two of which are somewhat close.But Democrats are defending 25 seats, so being back home is more consequential for them. Polls show that most of the red state Democrats are in competitive races.Sen. Heidi Heitkamp was back in North Dakota?before the deal was reached. She may be the most vulnerable Democrats running. She voted Wednesday on a health care bill that was a top priority for Democrats but wasn't around for votes later Wednesday or Thursday on Trump nominees.Asked about Heitkamp missing votes to campaign, her spokeswoman Abigail McDonough took a shot at the House, where her GOP opponent, Rep. Kevin Cramer, serves."Senator Heitkamp is back in North Dakota meeting with workers and families across her state," McDonough said. "Unfortunately, the House has only been in session for 10 days since the beginning of August, while the Senate has been working hard -- a telling statistic about the politics and work ethic in the House this year."As he walked on the Senate floor before the deal was announced, Democratic Sen. Jon Tester of Montana, a state Trump won by more than 20 points, was asked if he thought McConnell was playing hardball with the nominations to keep him in DC.He laughed loudly and said the answer was so obvious that even political reporters could determine on their own that it was true."Honest to God, I would answer that question, but I'm going to let you guys do that assessment," he said.Sen. John Cornyn of Texas, the second-ranking GOP leader, said McConnell had offered Senate Minority Leader Chuck Schumer "a list of nominations that are not particularly controversial, and if they will agree to dispose of them, then they'll be able to go back home" to "raise money and campaign."But Sen. Dick Durbin, the No. 2 Democrat, said some of the nominees "are clearly controversial," meaning Democratic leaders had to balance their desire to get their candidates home with essentially allowing judges they oppose to advance.Democratic leaders also recognized the risk that a deal that put more conservatives on the bench could anger and dispirit their base voters.Sen. Mazie Hirono, a Hawaii Democrat who become a hero to many progressives?for her handling of the contentious Brett Kavanaugh Supreme Court confirmation, said she wanted Schumer to cut a deal and get people home."Elections matter and I would like my colleagues to be able to go home," she said. "Every day that goes by when they're not touching base with their constituents is not a good thing"Hirono said she was not concerned about a backlash from Democratic voters if the deal appears favorable to Republicans."I hope that our supporters understand that, but we need to be focusing on is the outcome of the 2018 elections," she said adding that if Democrats control the Senate next year they will be able to block Trump's nominees they oppose. "Right now, we do not have those votes and I think they understand that."Sen. Joe Manchin, a Democrat running in West Virginia, which Trump won by 46 points, said he expected McConnell would demand a lot in return for letting Democrats go."Mitch is going to do what Mitch is going to do," he said. "I don't think you can make any deal with Mitch if he thinks he's going to get you."He also acknowledged he'd like to get home."It's always a good thing if we can be home campaigning," Manchin said. "We need to do that."Republican Sen. John Kennedy agreed that McConnell was dead set on getting a good deal for Republicans."He is mad as a mama wasp and he is determined to get the nominations through, and I don't think he's bluffing," Kennedy said. 4559

President Trump and Tony Soprano have the same taste in music, according to "Saturday Night Live."The NBC variety show opened its season finale on Saturday night with Alec Baldwin's Donald Trump sitting alone in a New Jersey diner. The faux president put a coin in his table's jukebox and suddenly "Don't Stop Believin'" by Journey began to play.Viewers at home have seen this scene before if they watched the series finale of HBO's acclaimed series, "The Sopranos." For the HBO's drama's finale, the titular character and New Jersey mob boss, Tony, plays the song as his family meets him for dinner."SNL" followed the iconic scene beat for beat with Baldwin's Trump being joined by his own "family." First was Kate McKinnon's Rudy Giuliani."So Rudy, did you go on Fox News last night?" Baldwin's Trump asked."Yeah, like 20 times," McKinnon's Giuliani responded. "Don't worry, I told them that you were openly colluding with Russia but ended with, 'SO WHAT?!'"Ben Stiller's Michael Cohen then joined the table and was asked how his day at work was."Really bad," Stiller's Cohen said. "Mostly just preparing to go to jail and stuff."Then Mikey Day's Donald Trump Jr. sat down and explained that Alex Moffat's Eric Trump was outside trying to "parallel park" his big wheel to no success.The nice dinner was going well for everyone until Robert De Niro's Robert Mueller appeared and sat alone at a different table."Am I the only one that sees that guy?" Baldwin's Trump said referencing Mueller.On his way to the bathroom, De Niro's Mueller gave Baldwin's Trump a quiet stare down leaving Trump to look frightened into the camera before, just like in "The Sopranos" finale, the scene immediately cut to black.Then the cast reappeared and said the show's catch phrase, "Live from New York... It's Saturday Night!" 1817

President Donald Trump says he is ready to get back on the campaign trail despite battling COVID-19.Trump said Thursday during an interview with Fox News' Sean Hannity that he is hoping to hold a rally in Florida on Saturday night if his campaign team has enough time to put one together.Trump's push for a rally comes just days after he was hospitalized for coronavirus. The 74-year-old publicly announced his positive test result early Friday morning and was receiving care at Walter Reed hospital before being released Monday evening. Trump has not yet given any specifics on where and what time he'd like the rally to kick off this weekend.Presidential physician Dr. Sean Conley released an update on Trump’s coronavirus prognosis on Thursday, stating that he has “remained stable and devoid of any indications to suggest progression of illness.”Trump was diagnosed with the coronavirus late Thursday night, just hours after traveling to New Jersey for a fundraiser. The following day, Trump was admitted to Walter Reed Medical Center as he was given an experimental antibody treatment, steroids, and other remedies to fight off the coronavirus.By Monday, Conley and Trump’s medical team signed off on releasing him to the White House.Conley said on Thursday he expects Trump to be able to resume public engagements on Saturday. 1340