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The World Health Organization updated its guidelines on mask-wearing Tuesday, recommending that anyone over the age of 12 wear a mask indoor and outdoor and inside your home if it's ventilated poorly.The updated guidelines come as COVID-19 cases continue to sore in America. On Wednesday, 180,083 new cases were reported, according to data from Johns Hopkins University.According to the guidelines, in areas where COVID is spreading, WHO recommends that anyone over the age of 12 wear masks in shops, shared workplaces, and schools if they can't maintain a distance of more than 3-feet between others.They also recommend masks be worn when people visit your home if there's not adequate ventilation, or you can't be more than 3-feet or more from each other.The WHO said on top of wearing a mask, other precautions such as washing hands, avoiding touching your face, having adequate ventilation if indoors, testing, contact tracing, quarantine, and isolation should also be taken."Together, these measures are critical to prevent human-to-human transmission of COVID-19," WHO said.In areas of COVID-19 spread, the organization said healthcare workers should take part in "universal masking" in health care facilities, meaning they should wear an N95 respirator mask throughout their entire shift, including when caring for other patients.The advice applied to visitors, outpatients, and common areas such as cafeterias and staff rooms, but added administrative staff does not need to wear a mask if they are not exposed to patients.The organization also recommended that people who do vigorous physical activity should not wear masks, citing some associated risks, particularly asthma.For children, the WHO recommends children up to 5-years-old should not wear masks for source control. They added that children between the ages of 6 to 11-years-old should only wear masks if "a risk-based approach is applied.""Factors to be considered in the risk-based approach include intensity of COVID-19 transmission, child’s capacity to comply with the appropriate use of masks and availability of appropriate adult supervision, local social and cultural environment, and specific settings such as households with elderly relatives, or schools," the organization added in its guidelines. 2285

The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The White House privately warned the mayors of 11 major U.S. cities on Wednesday that they need to take "aggressive" steps to control COVID-19 outbreaks, the Center for Public Integrity reports.The warning came from Dr. Deborah Birx, the response coordinator for the White House Coronavirus Task Force. In the call, which the Center for Public Integrity included "hundreds of emergency managers and other state and local leaders," she identified 11 cities that are seeing an increase in the percentage of positive COVID-19 tests they've taken in recent weeks. Those cities were Baltimore, Cleveland, Columbus, Indianapolis, Las Vegas, Miami, Minneapolis, Nashville, New Orleans, Pittsburgh and St. Louis.“When you first see that increase in test positivity, that is when to start the mitigation efforts,” she said in a recording obtained by Public Integrity. “I know it may look small and you may say, ‘That only went from 5 to 5-and-a-half [percent], and we’re gonna wait and see what happens.’ If you wait another three or four or even five days, you’ll start to see a dramatic increase in cases.”The Center for Public Integrity also published a seven-minute segment of the conference call.Public Integrity · Dr. Deborah Birx CallIt's unclear who provided the Center for Public Integrity with the recording, which was closed to the press. The outlet also reported that it's unclear which local governments were on the call, which was hosted by the White House Office of Intergovernmental Affairs. Officials in Cleveland told the outlet that they were not on the call.Birx's call came the day after President Donald Trump resumed his daily coronavirus briefings. During those briefings, Trump encouraged the nations to wear a mask when in public — a significant shift after he refused to do so in public appearances earlier this year. But Trump also seemed to downplay the severity of the virus by claiming that mortality is falling, despite figures from Johns Hopkins that show mortality increasing. 2009

The US believes that Ibrahim al-Asiri, a master al Qaeda bombmaker, is dead.The Saudi Arabian native was the mastermind behind the "underwear bomb" attempt to detonate a flight above the skies of Detroit on Christmas Day in 2009.A senior US official expressed "confidence that he was killed."Two US officials told CNN al-Asiri was killed by a CIA drone last year. The CIA is not commenting on his fate.CNN reported last week that al-Asiri may have been killed in Yemen last year, according to a UN team that tracks terrorist groups.Counterterrorism analysts say there should be significant skepticism over al-Asiri's possible demise for one major reason: His group, al Qaeda in the Arabian Peninsula, has not released any statement acknowledging his death, nor a eulogy celebrating his martyrdom.Al-Asiri is widely credited with perfecting miniaturized bombs with little or no metal content that could make it past some airport security screening. That ability made him a direct threat to the US, and some of his plots had come close to reaching their targets in the US.In addition to the "underwear bomb" attempt, al-Asiri was behind the so-called "printer bomb" plot. That plan saw him send explosive devices inside printers to the US. The two packages were being shipped from Yemen through Dubai and the UK in October 2010.Both were addressed to synagogues in Chicago.Al-Asiri appeared to have taken on a more public-facing role within al Qaeda in the Arabian Peninsula in recent years, including purportedly recording a speech the group released in 2016.The most recent public statement attributed to him was a written speech released by the group on September 12, 2017, to coincide with the 16th anniversary of the 9/11 terrorist attacks. The speech promised an ongoing war against the United States.CNN cannot independently verify he authored these statements.Few expect al-Asiri's expertise to die with him. Officials believe he trained a number of apprentices. And since 2014, US officials have been concerned that bomb-making expertise built up by al Qaeda in the Arabian Peninsula has migrated to other groups, including al Qaeda operatives in Syria.Meanwhile, ISIS is among the terrorist groups that have worked to develop laptop bombs, prompting large electronics to be temporarily banned in the cabin on certain flights to the United States and the UK from the Middle East last year. 2414

The Supreme Court granted Tuesday a Trump administration request to continue to bar most refugees under its travel ban.Without comment, the court blocked a federal appeals court ruling from last week that would have exempted refugees who have a contractual commitment from resettlement organizations from the travel ban while the justices consider its legality. The ruling could impact roughly 24,000 people.The travel ban bars certain people from Iran, Libya, Somalia, Sudan, Syria and Yemen from entering the US.The issue concerning the scope of the travel ban has been ricocheting through the courts since the spring when the Supreme Court allowed Trump's ban to go into effect except for those with a "bona fide" relationship to the United States. The order might give hope to supporters of the ban, but it may also simply reflect a desire on the part of the justices to maintain the status quo until the justices can hear the case next month."Although it may be tempting to see the order as a harbinger of how the court is likely to rule on the merits, it's better understood as a very modest procedural step to stabilize the full scope of the injunctions against the travel ban over the next four weeks," said Steve Vladeck, CNN Supreme Court analyst and professor of law at the University of Texas School of Law.The justices did not explain their reasoning, although it took five justices to make the decision.The court is expected to take up the legality of the travel ban October 10. 1500