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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — It's a weekend packed with Oktoberfests across San Diego County as October and the fall season kicks into fear.El Cajon, La Mesa, Carlsbad, and Julian all celebrate Oktoberfest this weekend, with fun fall festivals featuring delicious brews, games, folk music and dancing, and German cuisine.If you're looking for some early scares, Balboa Park's Haunted Trail is open for the season. Head to the park if you dare for a hike like none other.SAN DIEGO HALLOWEEN:Frightful fun: San Diego Halloween, fall events for familiesExperience Halloween chills at these San Diego attractionsSpirited shindigs: Halloween parties for San Diego's 21+ crowdPacific Beach and Mira Mesa also welcome the community out this weekend for their own street fairs, with live music, arts and crafts, and more fun in the sun.THURSDAYOktoberfest in El CajonWhere: German American Societies of San Diego; Cost: - (Thursday - Sunday) Enjoy live German "Oom-Pah" music, traditional foods like bratwurst and ox-on-the-spit, German beers, folk games and dancing, and a kids' zone at El Cajon's massive Oktoberfest party.Haunted Trail at Balboa ParkWhere: Marston Point; Cost: - (Thursday - Sunday) Prepare for a scare as you walk down the mile-long trail. The theme for 2019 is “Stranger Things” and features the swampy fog of the upside down. Pregnant women and young children are banned from entry.FRIDAYFall Home Garden ShowWhere: Del Mar Fairgrounds; Cost: Free - (Friday - Sunday) Get all you need to spruce up your home and garden for fall at the Del Mar Fairgrounds this weekend for the annual Fall Home Garden Show. Guests can put together their own succulents, get tips from design and gardening experts, check out seasonal foliage, and more.La Mesa OktoberfestWhere: La Mesa Village; Cost: Free to attend(Friday - Sunday) La Mesa Village claims their Oktoberfest is the largest this side of the Mississippi. Head over for three-days of traditional sing-a-longs, original glücklich games like stein races and keg bowling, contests and crafts, and traditional German dishes and food.SATURDAYPacific BeachfestWhere: PB Boardwalk, from Felspar St. to Thomas St.; Cost: FreeHit the Pacific Beach boardwalk for a festival on the sand, with multiple stages of live music, arts and crafts village, kids zone, beer garden, fish taco contest, and more to check out. The day kicks off with a 5K and volleyball tournament and runs through to a beautiful beach sunset.Mira Mesa Street FairWhere: Camino Ruiz, from Mira Mesa Blvd. to New Salem St.; Cost: FreeEnjoy live music across two stages, international foods, kids activities and inflatables, and more at the Mira Mesa Street Fair this weekend. The US Marines will be on hand to give visitors a look at their explosive ordinance disposal robot and visitors can take a peek into a solar telescope. Carlsbad Oktoberfest and Family Fall FestivalWhere: Holiday Park; Cost: Free - Not only can you enjoy Oktoberfest in Carlsbad, but help support the local Rotary Club. The event hosts costume contests, arts and crafts, games and rides, live music, and delicious authentic German meals and brews.SUNDAYKSON's CountryFestWhere: Del Mar Fairgrounds; Cost: - Grab your favorite pair of boots and head down to Del Mar to see country music stars Billy Currington, Blanco Brown, Jon Langston and Dillon Carmichael perform. Line dancing will surely be in the mix along with fun games and delicious foods and drink.Rendezvous in PowayWhere: Old Poway Park; Cost: Varies(Saturday - Sunday) Living history groups help bring the 1800's alive in Poway, where the annual Rendezvous in Poway gives visitors the chance to pan for gold, experience western reenactments, peruse handcrafted arts, and learn more about the west's early history.Oktoberfest in JulianWhere: Julian Town Hall; Cost: Free to attend(Saturday - Sunday) Julian hosts a fun-filled Oktoberfest and fall celebration with live traditional folk and polka music, craft booths, raffles for prizes, and delicious German cuisine and Julian treats. 4062

SAN DIEGO (KGTV) -- It's almost time for back to school and that means it's time to go shopping and gather all those essentials. While some items may be obvious on your shopping list, others are more obscure. We've compiled a list of back to school tech as you prepare to make that back to school shopping list. Check out the items below for more: Livescribe – 3.5 stars on AmazonThis nifty little gadget will come in handy for those long, note-taking days. With Livescribe, you can record everything you write and hear so you don’t miss a thing, according to Amazon. Then, replay your meetings or lectures simply by tapping on your notes. Native Union Key Cable – 5 stars on AmazonAlways losing that phone charger? The Native Union Key Cable attaches to your keychain so you never have that problem again (unless you can’t find your keys, of course.) The charger is compatible with most devices, according to Amazon. Casio Touchscreen with Stylus Graphing Calculator – 4 stars on AmazonTime for upper-level math classes? This graphing calculator has a 4.8 inch touchscreen with a stylus. The calculator also has an advanced computer algebra system for all those tough-to-solve math problems. iHome IBT29 Bluetooth alarm clock – 4 stars on AmazonDoes your student have a hard time waking up? The iHome Bluetooth dual alarm clock radio with speakerphone may be the solution (and it changes colors, which is just cool.) The alarm can be set to Bluetooth audio, FM radio or built-in tone. Pixie (4-pack) – 3 stars on AmazonDoes your student lose things often (who doesn’t?) The Pixie shows you at a glance the exact distance in feet and inches to the lost item, according to Amazon. Click here to scroll through a slideshow of the items listed above. 1756

SAN DIEGO (KGTV) -- Millennials are leaving San Diego in the thousands, according to a new report by Brookings. The new Census Bureau migration data reveal a post-recession shift in the migration of young adults and seniors. From 2007 to 2012, San Diego lost more than 7,400 people between the ages of 25 to 34 annually. From 2012 to 2017, the number dropped slightly to a little more than 7,000. RELATED: San Diego's median rent more than starting salaries for Class of 2019 483

SAN DIEGO (KGTV) — In lieu of traditional Dia de los Muertos events that invite San Diegans to honor their loved ones in-person, the county is hosting a virtual festival this year.San Diego County's Parks and Recreation Department will hold a virtual celebration from 1 p.m. to 3 p.m. on Sunday, Nov. 1. The online festival will feature dance performances, a cultural storytime, and an arts and crafts workshop:The festival will also include a tour of the Rancho Guajome Adobe, an authentic 1850s adobe hacienda located in Vista that is listed on the National Register of Historic Places.The holiday originated thousands of years ago in Mesoamerica (Mexico and northern Central America). Dia de los Muertos is not a somber holiday. Rather than mourning, ancient Aztecs, Mayans, and Toltec celebrated and honored the dead by providing food, water, and tools to aid their journey into the afterlife. These are the days their souls were believed to return to earth, and altars were used to help them find their way home.Today, the ritual has grown beyond Mexico but continues as a show of appreciation for the joy our loved ones brought to our lives.During Dia de los Muertos, we honor those that passed away with colorful arts and crafts, foods, costumes, and parades. Offerings are often set around a brightly decorated altar, known as “offrendas,” which includes radiant marigold flowers, decorated “calaveras” (skulls), photos, desserts, and candles.Participants of today's festivities can pick up craft kits free of charge, though a donation is appreciated, from five county parks and community centers this weekend, including:Heritage County Park: 2454 Heritage Park Row, San Diego; Hours: 9 a.m. – 5 p.m. daily; Phone: 877-565-3600Rancho Guajome Adobe: 2210 N. Santa Fe Ave., Vista; Hours: (Visitor Center and Adobe): 9:30 a.m. – 4 p.m. Wednesdays through Sundays; Phone: 760-724-4082San Elijo Lagoon Ecological Reserve and Nature Center: 2710 Manchester Avenue, Cardiff-by-the-Sea; Hours: 9 a.m. – 5 p.m., daily; Phone: 760-634-3026Sweetwater Summit Regional Park: 3218 Summit Meadow Road, Bonita; Hours: 9:30 a.m. – sunset, daily; Phone: 619-472-7572Waterfront Park: 1600 Pacific Highway, San Diego; Hours: 8 a.m. – 6 p.m. daily; Phone: 619-232-7275Participants are encouraged to call ahead of time to make sure supplies are still available.Old Town San Diego is not holding its annual Dia de los Muertos events, but businesses in the area will display altars, art, and decorations to mark the day from Oct. 15 - Nov. 17.MORE VIRTUAL EVENTSCOVID-19 Altar de Muertos: In honor of Dia de Muertos and the nearly 900 San Diegans who have died due to COVID-19, San Diego County Supervisor Nathan Fletcher and Assemblywoman Lorena Gonzalez, D-San Diego, will hold a Day of the Dead ceremony Sunday at the County Administration Center."The COVID-19 Altar de Muertos is our way of remembering those we have lost to this horrible virus," said Fletcher, co-chair of the county's COVID-19 Subcommittee."It provides an opportunity to reflect on the effect COVID-19 has had on all communities, but we should be paying special attention to the disproportionate impact it has made on Black, Brown and other communities of color. Every death because of COVID counts. Every life lost to COVID matters. It is now time to rededicate ourselves to protecting one another by taking the actions needed to slow the spread," he said.The ceremony at 5:30 p.m. to dedicate the COVID-19 Altar de Muertos will be live streamed. Viewing locations will be on Fletcher's Facebook and Twitter, https://www.facebook.com/SupervisorFletcherSD/ and https://twitter.com/SupFletcher. 3661

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