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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) -- In February, we spoke to Jelynn Malone from Mostra Coffee after her coffee shop won best roaster in the U.S. by Roast Magazine. Since then, things for small businesses like hers have been touch and loyal customers including high school juniors, Siya and Anoushka, wanted to help."A lot of businesses were closing. We both brainstormed about how we could help local businesses who have helped us in the past," said Anoushka." So they created a campaign called Loving the Locals. "We started a GoFund Me page and reached out to friends and family who were able to donate. With that money, we were able to donate to Mostra Coffee."And when Malone was ready to meet her donors she said, "I'm looking for adults, they didn't give me their names or tell me how much and I see these two young high school girls and they're like 'Are you Jelynn?'" To describe Malone as surprised was an understatement. "Then they hand over this large check to me and it says a thousand dollars and I'm completely shocked. I'm emotional, touched," Malone described. Malone's no stranger to giving back. A portion of her profits goes to farmers in the Phillippines, where she sources a lot of her product from. When the pandemic began, she donated gratitude boxes to frontline workers. All of her efforts never went unnoticed, even by young customers. "They [Mostra Coffee] continue to give back to community even during these difficult times and we felt that quality was important to us and it's what we were going for. We shared similar values and they were a great fit for us," Siya said. Mostra Coffee is the first business Loving the Locals has donated to. They have a GoFund Me and all profits will go to another small business once their goal is met. 1760

SAN DIEGO (KGTV) -- Legendary San Diego anchorman Jack White has passed away. White spent more than 30 years in America’s Finest City as a reporter and anchor at KGTV 10News.White grew up in Oceanside and graduated from Oceanside High School in 1957. He was even inducted into the school’s hall of fame for his contribution to the arts.White began his broadcasting career on the radio in the early 1960s before moving to TV where he spent 34 years at KGTV.On November 14, 2010, the City of San Diego declared Jack White Day. The county made a similar declaration. Many who worked with him called him a gentleman and a great coworker. After leaving 10News, White worked as a technical advisor on the movie “Anchorman.”White covered every story there was to be covered in San Diego. His Restaurant Row coverage was known as a 10News staple. His iconic line in this popular segment was "The meal was served piping hot, just the way I like it."White will be missed by many, both in the community and at 10News. 1014

SAN DIEGO (KGTV) — If you're single in San Diego, chances are you're not impressed by the dating field locally.At least according to Apartment List, which ranked 130 cities on their ability to provide singles with the best atmosphere. San Diego is, well, lukewarm according to the study.The city ranked 73 overall, right in the middle of the park and posting an overall score of 48 out of 100 possible points.RELATED: Love hurts: Price of a date in San Diego could cost you, study saysThe study ranked cities on their dating satisfaction, social satisfaction, dating affordability, and percentage of reported singles, using data from Apartment List’s Annual Renter Satisfaction Survey and Census Bureau American Community Survey 2017.When it broke down that way, only about 22% of respondents were satisfied with the dating in San Diego. How women and men feel about dating locally may give us an idea about why the city ranked where it did. About 17% of women and 35% of men were satisfied with dating here.Far more San Diegans, about 58%, were satisfied with their social lives in town. And looking at census data, the city posted a measly 22 out of 100 for percentage of singles.RELATED: Ideas for a first date in San DiegoAccording to Apartment List, San Diego's lacking singles population and low satisfaction rate with dating here don't make it an inviting city for singles. The price of dating in California is also abysmal.But social lives are thriving.Atlanta ranked as the best city for singles, followed by Madison, Wisc.; Washington, D.C.; Bloomington, Ind.; and New Orleans, La. Heading up the bottom of the list was a handful of California cities: San Bernardino, Calif.; Bakersfield, Calif.; Anaheim, Calif.; Fayetteville, N.C.; and lastly Stockton, Calif. 1779

SAN DIEGO (KGTV) — Mesmerizing works of art will hit San Diego's this Labor Day weekend as more than 300 tons of sand transform Broadway Pier into a sand sculptor's playground.From Aug. 31 to Sept. 2, the Port of San Diego will host the U.S. Sand Sculpting Challenge along the city's waterfront. This year's theme of "Wonder" will pay tribute to the Port's Wonderfront 2019 events, including Wonderspaces and Wonderfront music festival this November.The competition will feature 12 master sculptors from around the world to create museum-level quality sculptures out of nothing but sand. RELATED: San Diego's first-ever ice cream festival promises cool summer funThese pop-up works of art can reach up to 15 feet tall and weigh more than 20,000 pounds.Competitors will battle for more than ,000 in prize money and national pride. Returning this year will be 2018's grand prize winner Tom Koet from Melbourne, Fla., in addition to several U.S. competitors and other top talent from Canada, South Korea, the Netherlands, and elsewhere.In addition to the competition, visitors can check out an expanded kids zone with bounce houses, a bungie jump, and more, a giant sandbox where professionals will teach kids how to craft the perfect sand creation, live entertainment from several bands, and gourmet food trucks out and about.RELATED: Artists announced for Wonderfront music festivalA portion of proceeds will benefit local charities, including the Padres Foundation and e3 Civic High.Tickets are available online and special pricing is available for active-duty military and public safety personnel. Tickets cost for adults, for seniors 62 and older, for kids 2 to 12 years old, and are free for kids younger than 2 and under.For more information, visit the event's website online. 1801

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