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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) -- Members of a cannabis church in the Midway District say the San Diego Police Department had no right to raid their church and take seven pounds of marijuana. 185

SAN DIEGO (KGTV) -- If you own boat -- or even a kayak or a jet ski -- that's just sitting in a dock or on a trailer, you may be sitting on some extra income."Business has been ..." Karina Sanchez searches for the right words. "We can't even believe how great business has been, we're so so thankful for it."Sanchez and her husband are owners of Waterhorse Charters in Mission Bay. Opening just last year, they offer scuba diving tours, party cruises, fishing and whale watching excursions.When the pandemic hit, they were forced to temporarily shutdown by state mandate. But once given the green light to reopen, Sanchez says business has been booming, with people want to get out and do it safely."I feel like people get a little more comfortable going out in the water," says Sanchez, "Something that's outdoors; than having, for instance, a house party or just going to bars or something like that."Sanchez connects with many of her customers through the site GetMyBoat.Com, which is kind of like Airbnb for boats."There's some data that suggests the average boat is only used 8 to 10% of the year," says Val Streif, who represents GetMyBoat.com from their headquarters in Minneapolis. "And the other time it's just sitting in a dock or marina."Streif says GetMyBoat has listings from private boat owners and charter services in 184 countries around the world, offering everything from kayaks and jet skis to pontoon boats and yachts."This is a way for people to earn some supplemental income," says Strief, "When they're not using the boat for themselves for personal purposes."There are increased regulations during the pandemic -- stepped up cleaning, fewer passengers for social distancing and other steps depending on the boat or excursion offered."We require everybody to wear a mask while they're on board," says Sanchez, "When they rent a regulator -- which is the piece you put in your mouth when you're diving -- every time people rent one from us we make them buy the mouthpiece."Sanchez says the changes aren't hurting business, as they've been sold out. And they're not the only ones, which is why GetMyBoat.com looking for more boat owners to sign up and perhaps help themselves "stay afloat" during these tough times, by renting out their boat.Sanchez says the demand is definitely there."Everybody is just grateful they can go out on the water. So, it's been great." 2394

SAN DIEGO (KGTV) — It’s decision time for the San Diego Padres, who are trying to choose the right candidate to replace fired manager Andy Green.Widespread reports, confirmed by 10News, indicate the Padres have narrowed their search to two very different candidates.The first is 38-year-old Jayce Tingler, who has worked in a variety of coaching and front office roles with the Texas Rangers, but has no Major League managerial experience.RELATED: Padres' Yates wins Baseball Digest's top reliever awardThe second is 67-year-old Ron Washington, who managed the Texas Rangers to back-to-back World Series appearances in 2010 and 2011, before stepping down in 2014. He's currently the 3rd base coach for the Atlanta Braves.The Padres have previously stated a preference for an experienced manager, which could give Washington the edge. But the decision largely rests on the shoulders of general manager A.J. Preller, who is said to be high on Tingler’s ability to communicate with players in English and Spanish along with his understanding of baseball analytics.The timing of the decision remains unknown but both candidates were in San Diego this past week for second interviews with club officials.RELATED: Padres to unveil new 2020 uniforms in NovemberThe team fire Green days before the conclusion of the regular season. Green manned a 274-366 record during his four seasons with the team.Following Green's dismissal, Preller said "the biggest thing I know is we’re better than what we’ve shown," during a media conference. He added that he felt the team needed a "different voice, different direction" moving into the 2020 season."It's a big decision. You don't want to be sitting here in this spot again," Preller told media on hiring a new manager. "It'll be a good process. It'll be detailed." 1808

SAN DIEGO (KGTV) -- In a video that's going viral, John Cena and Nikki Bella give the public a glimpse into their San Diego home. The tour is lead by Nikki and her twin sister Bre Bella ahead of the season five premier of Total Bellas. The tour begins in a basement wine cellar and eventually makes its way through the rest of the home. Watch the tour in the player below:  406