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HONG KONG, July 19 (Xinhua) -- A gene controlled by male hormone was critical for the growth of liver tumor, leading to a higher incidence of the disease in men than in women, according to the Chinese University of Hong Kong which made the results public on Tuesday.There is a significant gender bias in liver cancer incidence. In Hong Kong, men are three times more likely to develop liver cancer than women. Such phenomenon prompted researchers from the university to carry out a genomic location analysis in liver cancer cells starting from 2008.The researchers discovered, out of 17,000 human genes, that a gene called Cell Cycle-Related Kinase (CCRK) was directly controlled by androgen receptor. They further found that CCRK was critical for the induction of signaling pathway leading to abnormal liver cell growth and tumor formation.The results also reveal that 70 percent of patients with liver cancer were found to produce high levels of CCRK. More importantly, these patients were more likely to have late-stage cancers and lived shorter than those with low CCRK level.Using mouse models, the researchers found that either lowering the level or blocking the signaling pathway of CCRK in liver cancer cells could significantly reduce the tumor growth rate.The study has validated that CCRK is an important gene that has potential to cause liver cancer and the gene can be tested as a new targeted therapy in future.Vice-Chancellor of the university Joseph Sung, who is also team leader of the research project, said the results explained why men have a higher risk of liver cancer than women and helped push ahead with the development of a novel treatment of the disease.The above study results were published online in July in Journal of Clinical Investigation.
BEIJING, Aug. 12 (Xinhuanet) -- A Connecticut woman who was savagely attacked by a pet chimpanzee and had her face deformed in 2009 was shown on TV with a new face Thursday.TV pictures revealed Charla Nash’s new nose, lips and eyelid, which were transplanted in May by doctors at the Brigham and Women’s Hospital in Boston.Nash said to the viewers that she can move her mouth, smile and smell. Her daughter Brianna added that her mother can even talk and eat better now.Dr. Bohdan Pomanhac led a 30-member surgical team to complete the face transplant in 20 hours. The team also transplanted two hands but these were later removed due to blood flow problem when Nash suffered pneumonia.Nash’s friend Sandra Herold owned a 15-year-old chimpanzee named Travis that attacked without any provocation when Nash was visiting Herold.Travis simply went berserk and could not be stopped even after Herold stabbed it with a kitchen knife. It would only let go of Nash after the police arrived and shot it dead.
WASHINGTON, Sept. 14 (Xinhua) -- Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published Wednesday in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells.Led by Yale Professor Hugh Taylor, the researchers bathed endometrial stem cells in cultures containing special nutrients and growth factors. Responding to these substances, the endometrial stem cells adopted the characteristics of beta cells in the pancreas that produce insulin. Over the course of a three- week incubation process, the endometrial stem cells took on the shape of beta cells and began to make proteins typically made by beta cells. Some of these cells also produced insulin.After a meal, the body breaks food down into components like the sugar glucose, which then circulates in the blood. In response, beta cells release insulin, which allows the body's cells to take in the circulating glucose. In this study, Taylor and his team exposed the mature stem cells to glucose and found that, like typical beta cells, the cultured cells responded by producing insulin. The team then injected diabetic mice with the mature, insulin-making stem cells. The mice had few working beta cells and very high levels of blood glucose.Mice that did not receive the stem cell therapy continued having high blood sugar levels, developed cataracts and were lethargic. In contrast, mice that received the cell therapy were active and did not develop cataracts, but the animals' blood sugar levels remained higher than normal.The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.Taylor said in a statement that the next step in the research will be to verify how long this treatment remains effective.
SAN FRANCISCO, June 28 (Xinhua) -- Microsoft on Tuesday launched its cloud service Office 365, which was the software giant's answer to competing products from Google and other companies.The service includes on-line versions of Word, PowerPoint, Excel, Outlook and other Office applications, as well as Microsoft 's communication and collaboration tools such as Exchange, SharePoint and Lync.It will allow users to work on files and documents at the same time using instant messaging and video-conferencing."Where does Office meet the cloud? It's Office 365, the absolute best productivity and collaboration service for business around the world," Microsoft CEO Steve Ballmer said at a webcast event.Microsoft said that Office 365 is now available in 40 markets with choices for small and big businesses ranging from 2 to 27 U.S. dollars per user per month.Office 365 will compete directly with the web-based Google Apps, which Google sells for 50 dollars per user per year.Microsoft's service was introduced in beta last year and the company said response was enthusiastic with more than 200,000 organizations signed up and began testing it in a few months."With a few clicks, Office 365 levels the playing field, giving small and midsize businesses powerful collaboration tools that have given big businesses an edge for years," Ballmer said in a statement.
WASHINGTON, June 23 (Xinhua) -- NASA's next Mars rover has completed the journey from its California birthplace to Florida in preparation for launch this fall, the U.S. space agency said Thursday in a statement.The Mars Science Laboratory (MSL) rover, also known as Curiosity, arrived Wednesday at NASA's Kennedy Space Center aboard an Air Force C-17 transport plane. It was accompanied by the rocket-powered descent stage that will fly the rover during the final moments before landing on Mars.The rover's aeroshell -- the protective covering for the trip to the Red Planet -- and the cruise stage, which will guide it to Mars, arrived at Kennedy last month. The mission is targeted to launch from Cape Canaveral Air Force Station between Nov. 25 and Dec. 18. The car-size rover will land on Mars in August 2012.The rover and other spacecraft components will undergo more testing before mission staff stack them and fuel the onboard propulsion systems. Curiosity should be enclosed in its aeroshell for the final time in September and delivered to Kennedy's Launch Complex 41 in early November for integration with a United Launch Alliance Atlas V rocket.Curiosity is about twice as long and more than five times as heavy as any previous Mars rover. Its 10 science instruments include two for ingesting and analyzing samples of powdered rock delivered by the rover's robotic arm. During a prime mission lasting one Martian year -- nearly two Earth years -- researchers will use the rover's tools to study whether the landing region has had environmental conditions favorable for supporting microbial life and favorable for preserving clues about whether life existed.