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发布时间: 2025-06-01 20:13:25北京青年报社官方账号
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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

  临沧下体臭   

BEIJING, Dec. 23 (Xinhua) -- The personal information of more than 6 million Internet users on CSDN, or China Software Developer Network, the country's largest programmers' website, was leaked by hackers, raising concerns about web security and triggering widespread panic.The leak was first exposed by China's leading anti-virus software provider, Beijing-based Qihoo 360, on Wednesday. The company said the leak included user IDs, passwords and e-mail addresses in clear text.The hacking case escalated on Thursday after the personal details of subscribers to more websites, including popular online gaming and social networking sites, were leaked.Online media reports said the personal data of up to 50 million Internet users has been leaked so far, but the number could not be independently verified.In response, the National Computer Network Emergency Response Technical Team/Coordination Center of China (CNCERT/CC) issued a statement Thursday, saying the CSDN's user data bank that leaked on the Internet was created before April 2009 and the passwords were stored in clear text, but the passwords had been encrypted after the data bank was upgraded in April 2009."Therefore, similar security problems have not been found in the newest user data bank," the statement said.Technical experts are investigating how many websites and users were actually involved in the hacking case, said Zhou Yonglin, director of the CNCERT/CC Operating Department."False information and exaggerations cannot be ruled out," he said.Nevertheless, CNCERT/CC has ordered CSDN to take immediate action in repairing the system hazards and providing users with timely security solutions.Computer security experts at Qihoo 360 believe the leak has spread to other websites."Many Internet users have registered the same passwords for their e-mail, microblog, online gaming and online payment accounts, so, if the server of one of the websites is hacked, their accounts and passwords on other websites would also be stolen," said Qihoo 360's Dr. Shi Xiaohong.Police authorities in Beijing told Xinhua on Friday that an investigation has been launched.WEB SECURITY IN QUESTIONDisgruntled Internet users in China rushed to change their passwords after the leak occurred, the largest of its kind in the history of China's Internet development."It is very annoying. I had to spend almost an hour changing the passwords of all my online accounts, especially those for payment accounts," said Li Xing, a white-collar worker at a technical company in Beijing.

  临沧下体臭   

UNITED NATIONS, Oct. 17 (Xinhua) -- China on Monday underlined the importance of safeguarding the peaceful use of outer space and preventing the weaponization of and an arms race in outer space, saying that "the outer space is the common wealth of mankind as the global public space."The statement came as Wang Qun, the Chinese ambassador for disarmament affairs, was taking the floor at the thematic debate on outer space at the First Committee of the UN General Assembly. The First Committee is in charge of disarmament and international security."The outer space is the common wealth of mankind as the global public space," Wang said. "The permanent peace of outer space is correlated to all nations' security, development and prosperity.""Meanwhile, with the growing reliance of mankind on outer space, the risk of the weaponization of and an arms race in outer space are on rise, and the uncertainties concerning outer space security are accumulating as well," he said. "Safeguarding the peaceful use of outer space and preventing the weaponization of and an arms race in outer space are common interest and obligations of all countries."In responding to the growing challenge for security in outer space, the international community also witnessed common grounds on opposing to the weaponization of outer space and advertising the Prevention of an Arms Race in Outer Space, he said.The General Assembly, for consecutive years, adopted " Prevention of an Arms Race in Outer Space" resolution by overwhelming majority of votes, calling for negotiations on an international legally-binding instrument on the prevention of an arms race in outer space at the Conference on Disarmament in Geneva."The mankind has marched into the 6th decade of outer space exploitation, and the manned space flight has made a history of 50 years," Wang said."Recently, China has successfully launched the Tiangong-1 ( Heavenly Palace 1) as a target spacecraft for rendezvous and docking experiment, which opens a new era of China's manned space flight, and also reflects that China is committed itself to the honorable objective of promoting the peaceful exploration and utilization of the outer space, maintaining peace and bringing benefit to mankind."

  

BEIJING, Nov. 15 (Xinhua) -- Police from China and Angola have jointly busted a criminal gang that kidnapped Chinese females and forced them into prostitution in Angola, according to China's Ministry of Public Security on Tuesday.Police rescued 19 Chinese females during the operation on Oct. 25, when 11 suspects were arrested in Angola and five were caught in China, according to a statement from the ministry.Those female victims and suspects have been transferred back to China, said the statement.In order to boost international cooperation against human trafficking, China had ratified the Protocol to Prevent, Suppress and Punish Trafficking in Persons, Especially Women and Children, supplementing the United Nations Convention against Transnational Organized Crime, in February 2010.Moreover, Chinese police have entered into cooperation agreements with more than 50 countries, which contain anti-human trafficking terms.

  

UNITED NATIONS, Nov. 21 (Xinhua) -- Dramatic progress in science, political leadership, and results indicate that 2011 was a "game changing" year for the international AIDS response, and much progress has been made in 2011 to check AIDS-related deaths since 1997, the peak of the epidemic, a new report released by the Joint United Nations Program on HIV/AIDS (UNAIDS) said on Monday."The Report on the Global AIDS Epidemic 2011" found that new infections were reduced by 21 percent since 1997, and deaths from AIDS-related illnesses decreased by 21 percent since 2005, according to the report.Furthermore, 47 percent (6.6 million) of the estimated 14.2 million people eligible for antiretroviral therapy treatment in low- and middle-income countries were accessing treatment, in increase of 1.35 million people since 2009.The report also found early signs that HIV treatment is having an impact on reducing the number of new HIV infections. As treatment reduces the viral load of a person living HIV to almost undetectable levels, it also reduces the risk of transmitting the virus to an uninfected partner, according to the report. Studies also show that treatment can be up to 96 percent effective in preventing HIV transmission among couples.Eleven countries, including many Sub-Saharan African countries, reached "close to universal access" for AIDS treatment, which is determined to be 80 percent access, in 2011.Botswana made the most dramatic progress in scaling up access to treatment, the report said. While sexual patterns remained relatively stable in the country since 2000, access to treatment increased from less than 5 percent in 2000 to more than 80 percent in 2011.Despite progress, however, the report does note that 2011 marks an unprecedented high the number of people infected with HIV worldwide.Globally, an estimated 34 million people are currently living with the infection. Approximately 2.7 million got infected with the virus in 2010, and as many as 1.8 million people died of AIDS- related illnesses in 2010.Yet the report also notes estimates that as many as 2.5 million deaths are estimated to have been averted in low- and middle- income countries due to increased access to HIV treatment since 1995."Now is not the time to reduce our efforts despite some good news on reducing new infections. Infections are decreasing, but not rapidly enough," said Kim Nichols, executive director of African Services Committee, on Monday at a press conference."There are fewer AIDS deaths, but with the number of infections increasing, prevention has to be the mainstay of our response," Nichols said.Indeed, the UNAIDS report calls for a new framework for investments which are focused on "high-impact, evidence-based, high-value strategies," according to a press release from the UNAIDS website.The framework, which aims to achieve universal access to treatment and prevention centers by 2015, requires a 22-24 billion US dollar funding increase by 2015.Given the withering state of the global economy -- donor funding for the AIDS response has dropped from 7.6 billion in 2009 to 6.9 billion in 2010 -- raising that kind of money may be a long shot. Regardless, UNAIDS'new investment plan calls for smarter uses of less money.According to the report, the framework will focus on high-risk populations like sex workers, men who have sex with men, and people who inject drugs and prevent infections among children, as well as invest in behavior change programs, condom promotion, and treatment, care and support for people living with HIV."The world faces a clear choice: maintain current efforts and make incremental progress, or invest smartly and achieve rapid success in the AIDS response," says the UNAIDS report.

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