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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735

Claire Foy, the actress who starred as Queen Elizabeth II in the Netflix series "The Crown" was paid less for her Golden Globe-winning performance than supporting actor Matt Smith, according to Variety.The entertainment publication cites the CEO, creative director and production designer of Left Bank Pictures, the company that produced "The Crown" for Netflix.Smith, who played Queen Elizabeth II's husband Prince Phillip, was reportedly paid more because of his previous work as the lead role the hit TV show Doctor Who — a move which producers say will not happen on "The Crown" in the future."Going forward, no one gets paid more than the Queen," said Suzanne Mackie, the creative director for Left Bank according to Variety.That won't mean much for Foy, as her run as Queen Elizabeth II ended after the most recent season of "The Crown." Olivia Colman will take over the role as the series jumps forward in time for season three. Smith will also not return as Prince Phillip, though it has not been announced who will take his place.Foy won the Golden Globe in 2017 for "Best Performance by an Actress in a Television Series - Drama," in 2017, and was nominated for the award again in 2018. She was also nominated for "Outstanding Lead Actress in a Drama" at the 2017 Primetime Emmys.The revelation comes just months after reports surfaced that actor Mark Wahlberg was paid .5 million to reshoot scenes from "All the Money in the World," while co-star Michelle Williams was only paid ,000. Both Wahlberg and Williams reportedly had the same agent at the time.Alex Hider is a writer for the E.W. Scripps National Desk. Follow him on Twitter @alexhider. 1700

CORONADO, Calif. (KGTV) -- A celebration of life was held in Coronado Thursday night for Nicole Quitasol, the San Diego woman killed in a boat fire off Santa Cruz Island. The event was held at Nicky Rottens, and restaurant officials said the celebration of life was also to help the fundraising efforts to support Quitasol’s family. Quitasol was on the dive trip with four family members, her coworkers posted on Facebook. "Nicole has worked with our Nicky Rottens Coronado family for years, and she will be remembered as an adventurous & loving soul," wrote Bryn Butolph, who described Quitasol as smart and loving.RELATED: San Diego woman killed in deadly Conception boat fire off Santa Barbara"She will be greatly missed," Butolph added. He told 10News Quitasol was devoted to her dog, Peanut Butter.The family of five was among the 34 presumed dead following the blaze. All were sleeping below deck when the fire broke out in the early morning hours of Sept. 2. Other victims included students from a Northern California charter school serving grades 7-12, and a marine biologist who owned the diving company and was leading the tour.A GoFundMe account was created to help Quitasol's mother, who lost three children.KCRA in Sacramento identified the other family membersas Nicole’s sister Evan and sister Angela, both from Stockton, and their father Michael and stepmother Fenisa Sison, both from Modesto. 1421

CORONADO, Calif. (KGTV) - A Coronado police officer and four teens were injured after a suspected drunk driver crashed into a parked car Friday.Coronado Police received a report of a possible drunk driver at about 9:30 p.m. An officer in the area located the vehicle on Third Street and attempted to stop the vehicle. The driver, however, made an abrupt turn onto E Ave. and crashed into a parked vehicle, police said.Following the crash, several juveniles ran from the vehicle. The responding officer chased after the teenagers and found two nearby. They were brought to a nearby hospital for injuries sustained in the crash.Two more passengers were found hiding near 4th St. and Alameda Blvd. They were also taken to a nearby hospital for injuries received in the crash, police said.Coronado Police said an officer was also injured responding to the incident.Police said several containers of beer, hard alcohol, and spray paint were found inside the vehicle. 984

Cleveland Cavaliers star LeBron James never played college ball, and he made clear in a press conference Tuesday that he's not a fan of the sport."The NCAA is corrupt," James said. "I'm sorry, it's going to make headlines, but it's corrupt.""I'm not a fan of how the kids don't benefit from none of this," he added.James also suggested that the NBA expand its developmental league, the G League, so it could one day become a viable option for top high school players who don't wish to play in college.He also implied he may not send his children to college if they wish to pursue basketball."It's kind of a fine line, because I have a couple of boys that could be headed in that direction. There's going to be decisions that we as a family are going to have to make," James said.  793