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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

ADDIS ABABA, Nov. 15 (Xinhua) -- The African Union (AU) Commission Chairperson Jean Ping on Tuesday met and held talks with a high level Chinese delegation led by Jiang Yaoping, Chinese Vice Minister of Commerce.The discussion between the two sides was mainly focused on the cooperation between China and Africa in different sectors.Ping said AU is ready to do all possible to further strengthen its ties with China.The Chairperson said China has been working in cooperation with AU member states on various areas, including trade, investment, and diplomatic exchanges."We are happy to meet the delegation; a delegation not only as an important partner but as a friend of Africa, a friend with which we are strengthening cooperation constantly," said the Chairperson.He also reiterated that Africa is benefited from the relations with China.He said Africa has established an important relations with China within the China-Africa Cooperation Forum (FOCAC), and the two sides are now engaged in strategic dialogue on very crucial areas.Jiang said that AU has been committed to economic integration in Africa that enable member states improve the livelihoods of Africans.He also said that AU has played a constructive role in meeting global issues like the climate change.The Vice Minister stated that China has become one of the most trading partner of Africa, and the trade volume between China and Africa is increasing from time to time.Leading the delegation, Jiang has also visited the African Union Conference Center (AUCC) Project which is almost completed and is expected to be the avenue of the coming AU Summit for the first time at its own headquarter.

BEIJING, Dec. 14 (Xinhua) -- China's new yuan-denominated lending in November rose 7.8 billion yuan (1.2 billion U.S. dollars) year-on-year to 562.2 billion yuan, the People's Bank of China, the central bank (PBOC), announced Wednesday.New loans in the month were smaller compared to that in October, which stood at 586.8 billion yuan.By the end of November, the outstanding broad money supply (M2), which covers cash in circulation and all deposits, rose 12.7 percent year-on-year to 82.55 trillion yuan, according to data released by the PBOC.Meanwhile, the narrow measure of money supply (M1), which covers cash in circulation plus demand deposits, increased 7.8 percent year-on-year to 28.14 trillion yuan by the end of last month, the figures showed.New yuan deposits last month fell sharply to 324.7 billion yuan, down 262.6 billion yuan year-on-year. Outstanding yuan-denominated deposits totaled 79.51 trillion yuan as of the end of last month, up 13.1 percent year-on-year, however, the growth rate was 6.5 percentage points lower compared to the same period last year.Meanwhile, outstanding foreign currencies-denominated deposits stood at 266.8 billion U.S. dollars, up 12.9 percent year-on-year. New deposits of foreign currencies rose 4.1 billion U.S. dollars year-on-year.

BEIJING, Oct. 21 (Xinhuanet) -- A team of European researchers announced that they have found vast water vapor out of our solar system, according to a study in the U.S. journal Science Friday.Using Herschel Space Observatory, a European Space Agency satellite, the researchers observed that the vast water vapor enveloped a 175-light-year-away star and its surrounding dusk disk, which will eventually form a planet.The water vapor, which is "enough to fill thousand of Earth ocean", may rain down and seed the future oceans on the young planet, as it did on the Earth 4.5 billion years ago, the researchers suggested."Scientists have long suspected there were these reservoir of cold water hiding in the outer regions of planet disk, ... now the theory gets considerably stronger." said astronomer Michiel Hogerheijde of Leiden Observatory in the Netherlands.The finding not only explained where our Earth's ocean came from, but also indicated that there are likely to be many "ocean worlds" throughout the galaxies, he concluded.

ADDIS ABABA, Dec. 1 (Xinhua) -- Marking the World AIDS Day on Thursday at the African Union (AU) headquarters in Addis Ababa, Ethiopia, Jean Ping, the AU Commission chairperson, said Africa should no longer see new generations with HIV infection.Through his representative, Ping called upon individual and collective action to contain mother to child transmission of HIV."We should act individually and collectively not only to prevent mother to child transmission but also to take care of the health of people living with the virus," said the chairperson.He also expressed commitment of the AU Commission to work with member states and pertinent bodies in the efforts made to HIV treatment and prevention.The World AIDS Day is commemorated this year under the theme "Zero Mother to Child Transmission", as world leaders who were gathered in New York for the 2011 United Nations (UN) High Level Meeting on AIDS in June, launched a Global Plan for significant strides towards eliminating new HIV infection among children by 2015 and keeping their mothers alive.Remarkable progress has been made so far, which is proof to realize the vision of zero new HIV infection, zero discrimination, and zero AIDS-related death (the three zeros), said UN Secretary General Ban Ki-moon in the message on the commemoration of the World AIDS Day.The secretary general revealed that the number of new infections has fallen by more than 20 percent since 1997, and new infections are continuing to decline in most parts of the world.In sub-Saharan Africa, the region most affected by the AIDS epidemic, HIV incidence has decreased in 22 countries, he said.According to UNAIDS, Ethiopia, Nigeria, South Africa, Zambia, and Zimbabwe are among the African countries where new HIV infections dropped significantly."Treatment has averted 2.5 million AIDS-related deaths since 1985. Last year alone, 700,000 lives were saved. Some 6.6 million people, nearly half those who need treatment in low and middle- income countries, are now receiving it," said Ban."Synergies between prevention and treatment are speeding up progress. But, to end AIDS, we need to deliver even greater results," said the secretary general.The UNAIDS says to get to the three zeros there must be acceleration on smart investments, capitalizing on scientific advancements and respecting human rights.Speaking at the AU headquarters on the commemoration of AIDS Day, Jan Beagle, deputy executive director of UNAIDS, underlined on the need to invest smartly to achieve the vision of the three zeros.There is a global target of 22 million U. S. dollars to 24 billion dollars to fund the AIDS response, which the UNAIDS says is a shared responsibility of all countries, donors and others."International assistance for the AIDS response has declined from 8.7 billion dollars in 2009 to 7.6 billion in 2010," said the Deputy Executive Director."We need to use new technology more effectively to reduce costs and demonstrate that we can deliver return on investment," she said.The AIDS movement is a movement for inclusiveness, equity and social justice, she said, adding that it has demonstrated global solidarity is possible to address multi-sectoral challenges.According to Abdoulie Janneh, executive secretary of the UN Economic Commission for Africa (ECA), an estimated 7,000 people get infected with HIV infections every day.The executive secretary highlighted ingenious and novel approaches in introducing new HIV/AIDS prevention strategies."A combination of the traditional initiatives and innovative initiatives can all be used to eliminate new HIV infections," said Janneh.