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SAN DIEGO (CNS) - UC San Diego announced Monday a million gift from the John and Mary Tu Foundation, designated to help increase the number of people tested for COVID-19, as well as develop new ways to track and treat the virus.The award supports the clinical research activities of UCSD translational research virologist Dr. Davey Smith, who is "advancing new diagnostics, therapies and ways to monitor the spread of the virus," according to a university statement."What we are trying to do is save lives," John Tu said of the gift to create the John and Mary Tu Foundation COVID-19 Response Fund. "It's very simple: with this research, Dr. Smith is working on behalf of everybody, to save us, to save the world."At the onset of the pandemic, Smith and his team began to investigate methods that would increase the efficiency of testing as well as understand the disease process -- how the virus mutates and spreads within a population. Through sequencing the virus, he is able to track the disease as it spreads into vulnerable populations, which informs the best means for contact tracing.Smith is also leading clinical trials to test new drugs for treatment of COVID-19 for those who have moderately severe cases."At this critical time during the COVID-19 pandemic, the generosity of the John and Mary Tu Foundation has an immediate positive impact on our efforts," said UCSD Chancellor Pradeep K. Khosla. "Their support allows experts like Davey Smith to quickly mobilize to mitigate the spread of the virus and develop treatments for those affected."Smith said the gift was important, as he and his team had limited resources, which would have frozen their progress."The foundation saw that time was of the essence in this pandemic and that science was going to get us out of it," he said. "Now we are conducting a number of clinical trials, including those for vaccines, and have found new drugs that will likely move to treatments soon."As chief of UC San Diego's Division of Infectious Diseases and Global Public Health and co-director of the San Diego Center for AIDS Research, Smith and his team are positioned to rapidly respond to the spread of pandemics like COVID-19."It's not a matter of if a pandemic can happen, but when," Smith said. "We need to bolster science, technology and capabilities to prepare for pandemics." 2347
SAN DIEGO (KGTV) - A company with offices in Oceanside released data Friday supporting its drug remdesivir is helping severely ill COVID-19 patients recover.The data released by Gilead, who produces remdesivir, states there was a 62% reduction in risk of death, compared to patients who weren't given the drug, and 74% of remdesivir treated patients recovered by Day 14.Remdesivir was originally created to fight Ebola, a similar virus to COVID-19.Troy Kahle was diagnosed with COVID-19 and said he's alive today because of Kaiser Permanente doctors, nurses and remdesivir.He said he was admitted to the hospital March 14, and ended up in a coma for 12 days."The first memory I have is waking up with my hands strapped to the gurney and a tube down my throat," Kahle said he thought he was going to die and wishes no one to face what still haunts him.Friday he celebrated three months out of the hospital as a survivor of COVID-19.While the drug has helped people like Kahle, medical experts are wary."It's not a magic bullet," Molecular Biology Professor at UC San Diego Stephen Hedrick, PhD. said.He said the drug slows down the virus."It's going to decrease the severity of the symptoms of the viral infection, but it doesn't necessarily make you well overnight," he said comparing it to an antibiotic.This is because while the drug works to stop the virus from replicating, COVID-19 can counter it, "Coronaviruses, almost uniquely among RNA viruses, have an error correction capability."Survivors like Kahle, while thankful to be out of the hospital, aren't back to 100%."I get easily winded if I overexert myself, occasionally I'll get dizzy for no reason, I have foot pain when I wake up," Kahle said.Hedrick said he is optimistic, adding the drug is a good jumping off point to create a drug more suited to coronavirus, or a vaccine.In the mean-time both Kahle and Hedrick ask that we all wear our masks."If we all work together we can get to the other side of this pandemic," Kahle said.Gilead said they are ramping up supplies, "we have increased supply nearly 40-fold since January and our goal is to produce more than 2 million treatment courses by year-end and several million in 2021, if required."Gilead cautions that rigorous clinical trials are needed to confirm the latest data. 2303

SAN DIEGO (KGTV) -- A 25-year-old man has been taken into custody after his 53-year-old mother was found dead Monday evening in the College West neighborhood. Officers were called to the 4800 block of Collwood Boulevard around 4:40 p.m. Monday night after receiving reports of a deceased person inside a home. According to San Diego Police, family members tried to contact the 53-year-old woman who lived inside, but had not been able to contact her for several days.When officers entered the home, they found the woman dead.“Information provided by family members led to the 25 year-old son being located at an area hospital where he was receiving treatment for injuries he sustained to his hands,” police said.The man has been taken into custody and will be transported to headquarters for processing as a possible suspect, police said. 846
SAN DIEGO (CNS) - With coronavirus cases surging statewide and hospital beds expected to fill rapidly, Gov. Gavin Newsom said Monday a more sweeping stay-at-home order could soon be imposed in the vast majority of California in hopes of preventing the health care system from being overrun.Newsom said nine more of the state's 58 counties have been moved into the most restrictive "purple" tier of the state's COVID-19 monitoring system, meaning 51 counties are now in that tier. And those counties would be the ones likely subjected to a stay-at-home order reminiscent of the restrictions that were imposed at the onset of the pandemic, he said. All of Southern California is in the "purple" tier."The red flags are flying in terms of the trajectory in our projections of (case and hospitalization) growth," Newsom said. "... If these trends continue we're going to have to take much more dramatic, arguably drastic action, including taking a look at those purple tier counties."He said those actions include "the potential for a stay-at-home order for those regions in purple."The action follows what Newsom called an 89% increase in hospitalizations statewide over the past 14 days, and projections that the number of hospitalizations could double or triple within a month, based on the surging case numbers over the past two weeks. The state projects that 78% of hospital beds will be filled by Christmas Eve, and all currently available intensive care unit beds will be occupied by mid-December."We're now looking in real time at hospitalization numbers and ICU capacity in those regions," he said. "We are assessing this in real time over the next day or two to make determinations of deep purple moves in those purple tier status (counties) that is more equivalent, more in line with the stay-at- home order that folks were familiar with at the beginning of this year, with modifications in terms of the work that we are currently doing."Newsom noted that all hospitals have the ability to increase bed capacity, and the state has 11 surge facilities planned statewide that can add nearly 1,900 beds. But providing staffing for all of those beds could be an issue, he said.Dr. Mark Ghaly, the state's Health and Human Services Secretary, noted that since hospital numbers tend to rise about two weeks later than cases are confirmed, the impact of the infection surge over the past two weeks has not even begun to impact the already elevated hospitalization numbers.Ghaly said everything is on the table in terms of confronting the surge, including the possible stay-at-home order."Everything is on the table in considering how we effectively guide the state through this, and working with our local partners to make sure what we do is both impactful and as time-limited as possible," Ghaly said. "We know this is hard for all Californians, and (we are) making sure that we choose something that will make a difference but that we can track that difference and give people some confidence that we will only do it as long as we need to to bring the hospitals into a situation that they can handle the incoming patient numbers and provide high-quality care in a way that protects our health care workforce as well." 3227
SAN DIEGO (KGTV) - 10 years ago, a Poway teen disappeared during a jog, and a collective sense of security was never the same. What followed were massive searches and an outpouring of support from the community. The investigation led to the arrest of the man who killed teenagers Chelsea King, 17, and Amber Dubois, 14. Carrie Cave's daughter Amber vanished in 2009 while walking to Escondido High. She planned to purchase a lamb that day and raise it as part of a school program. Her fate was revealed a year later after Poway High School senior Chelsea King went missing during a jog near Lake Hodges."I remember not being able to breathe. Your whole body is shaking," said Brent King, Chelsea's father.The evidence trail led to convicted sex offender John Gardner, who was ultimately convicted for a series of crimes, including the rape and murder of the two girls. Their bodies were recovered. After an emotional confrontation with Gardner in prison, Cave decided to forgive Gardner before he was sentenced."I got the answers about her last moments that I wanted ... I forgave him because I had another daughter to raise, and if I didn't, I wouldn't be able to live," said Cave.Cave started a search and rescue group. Her dog Amber discovered the remains of missing San Diego native and nursing student Michelle Le in the Bay Area in 2011."It was a lot to take in. I sat under a tree for two hours and cried," said Cave.That emotion is something the King family also knows well. The family channeled their grief and helped pass Chelsea's Law, a state law which enhanced sentences, parole terms and monitoring for violent sex offenders who commit crimes against children. To date, more than 2,500 offenders have been charged under Chelsea's Law."Because of Chelsea's Law, our children are safer, but that doesn't mean they're safe," said King.Besides advocating for laws, the King family's nonprofit Chelsea's Light Foundation has handed out over 0,000 in scholarships to local children. A run celebrating Chelsea's memory was held for eight years, before coming to an end.In 2014, Chelsea’s brother Tyler King directed a documentary he called “Chelsea’s Light: A Brother’s Journey.” "She is with us. That's the best I can tell you. She drives us every day to smile, to see life in a really beautiful way," said King.For Cave, a decade after the arrest of her daughter's killer, her grief is still complicated."It gets easier, but it still hurts ... I do good sometimes and then my emotions get all screwed up," said Cave.Cave says her she's still forging her daughter's legacy. She plans to start fostering children in the probation system."Not many people are willing to take in the kids. I just want to help kids. That would be a good legacy," said Cave. 2773
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