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WASHINGTON, Dec. 21 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Wednesday approved Isentress for the treatment of HIV-1 infection for children and adolescents.The drug is part of a class of medications called HIV integrase strand transfer inhibitors that works by slowing the spread of HIV in the body. It was first approved for use in adult patients in October 2007, under FDA's accelerated approval program."Many young children and adolescents are living with HIV and this approval provides an important additional option for their treatment," said Edward Cox, director of the Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research.Isentress is a pill that can be taken twice daily, with or without food. The pill is also available in a chewable form. As the two tablet formulations are not interchangeable, the chewable form is only approved for use in children ages 2 to 11.A single, multi-center clinical trial of 96 children and adolescents aged 2-18 years with HIV-1 infection evaluated the safety and effectiveness of Isentress. These patients previously received treatment for HIV-1 infection. After 24 weeks of treatment with Isentress, 53 percent of these patients had an undetectable amount of HIV in their blood.According to the FDA, the most commonly reported severe, treatment-related side effects in patients taking Isentress include trouble sleeping and headache. The frequency of these side effects is similar for children and adults. One pediatric patient reported severe treatment-related insomnia, while another pediatric patient experienced a drug-related skin rash.

BEIJING, Oct. 25 (Xinhuanet) -- Steve Jobs, Apple's co-founder and former CEO, may be one of the great men who will still be influential after their deaths.The new biography of Steve Jobs is likely to be the top-selling book 2011 of Amazon.com Inc, an online book retailer, according to Amazon spokeswoman Brittany Turner Monday."It could very likely be our top-selling book of the year," Turner said in a statement cited by the Reuters.Steve Jobs, written by Walter Isaacson, former Time magazine managing editor, was landed on shelves in bookstores Monday.But its digital version was reported to be released late on Sunday on Apple's iBooks online store and Amazon's Kindle eBook store.Since its release, the biography, both electronic and physical versions, has performed very well in Amazon.It is the best-selling book on Amazon.com and the top-selling electronic book on the Kindle as well. According to the Reuters, Isaacson was asked by Jobs to consider writing a biography for Apple's former CEO in 2004, when Jobs was going to be operated on for pancreatic cancer.Then Isaacson had more than 40 exclusive interviews with Steve Jobs. The last such interview was on October 5, one week before the giant's death.

WASHINGTON, Nov. 14 (Xinhua) -- A novel study in twins found that exposure to trichloroethylene (TCE) -- a hazardous organic contaminant found in soil, groundwater, and air -- is significantly associated with increased risk of Parkinson's disease (PD). Possibility of developing this neurodegenerative disease is also linked to perchloroethylene (PERC) and carbon tetrachloride (CCI4) exposure, according to the study appearing in Annals of Neurology on Monday.The National Institute of Neurological Disorders and Stroke estimates that as many as 500,000 Americans have PD and more than 50,000 new cases are diagnosed annually. While there is much debate regarding cause of PD, studies suggest that genetic and environmental factors likely trigger the disease. Several studies have reported that exposure to solvents may increase risk of PD, but research assessing specific agents is limited.The current epidemiological study, led by Samuel Goldman and Caroline Tanner with The Parkinson's Institute in Sunnyvale, California, investigated exposure to TCE, PERC and CCI4 and risk of developing PD. The team interviewed 99 twin pairs in which one twin had PD and one didn't, inquiring about lifetime occupations and hobbies. Lifetime exposures to six specific solvents previously linked to PD in medical literature -- n-hexane, xylene, toluene, CCI4, TCE and PERC -- were inferred for each job or hobby.The findings are the first to report a significant association between TCE exposure and PD -- a more than six-fold increased risk. Researchers also found that exposure to PERC and CCI4 tended toward significant risk of developing the disease. "Our study confirms that common environmental contaminants may increase the risk of developing PD, which has considerable public health implications," commented Goldman in a statement.TCE, PERC and CCI4 have been used extensively worldwide, with TCE noted as a common agent in dry-cleaning solutions, adhesives, paints, and carpet cleaners. Despite the U.S. Food and Drug Administration (FDA) banning the use of TCE as a general anesthetic, skin disinfectant, and coffee decaffeinating agent in 1977, it is still widely used today as a degreasing agent. In the U.S., millions of pounds of TCE are still released into the environment each year and it is the most common organic contaminant found in ground water, detected in up to 30 percent of drinking water supplies in the country.In a release issued on Sept. 28, 2011, the Environmental Protection Agency announced that TCE is carcinogenic to humans.

HONOLULU, United States, Nov. 13 (Xinhua) -- Chinese President Hu Jintao and leaders of other Asia-Pacific Economic Cooperation (APEC) members met in Honolulu, Hawaii, Sunday to find ways to speed up regional economic integration, free trade and investment, and economic and technological cooperation.The annual meeting, hosted by U.S. President Barack Obama in his home state, is being convened at the JW Marriott Ihilani, Honolulu, to boost regional economic integration, trade, green growth, job creation in green industries, energy security, and regulatory cooperation.President Hu is expected to speak at the meeting. He will introduce China's stand on the topics and call for "improving global economic governance, shifting the growth methods, promoting economic globalization and regional economic integration," according to Chinese diplomats.Hu will join other APEC leaders in meeting with the APEC Business Advisory Council (ABAC), which presents recommendations to APEC leaders in an annual dialogue and advises APEC officials on business sector priorities and concerns.During this year's dialogue, APEC leaders are expected to discuss regional economic integrity, the development of small- and medium-sized enterprises, food security and other issues with ABAC representatives.This year's APEC meeting convenes at a time when the global economic recovery is fraught with instability and uncertainty, and encounters growing risks and challenges.Some major economies are experiencing an economic slowdown, while in the eurozone, sovereign debt risks are rising in some countries. High inflationary pressure is a problem in emerging economies, including some in the Asia-Pacific region. Protectionism in various forms is mounting.In face of the challenges, the APEC leaders will look for effective measures to stimulate the global economy, regional economic integration, free trade and investment, and economic and technological cooperation.China hopes the APEC members will implement the economic growth strategy agreed on last year, striving to achieve a balanced, inclusive, sustainable, innovative and safe economic growth, said Wu Hailong, assistant foreign minister of China, at a press briefing last week.He said that China expects the APEC members to comprehensively promote regional trade and investment liberalization, adding that all members should fulfill their commitments and oppose all forms of trade protectionism.APEC should strengthen economic and technical cooperation to enhance the ability of the developing members to develop further, and therefore to achieve common prosperity, said the senior diplomat."APEC members generally hold positive attitudes toward U.S. proposals in various fields such as green growth, innovation policy. But some of the U.S.'s expected outcomes are beyond the capacity of the developing members, and they have expressed their difficulties and concerns," Wu said.

WASHINGTON, Dec. 12 (Xinhua) -- British scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published Monday in the U.S. journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels.Cancer cells gain the nutrients they need by producing proteins that make blood vessels grow, helping deliver oxygen and sugars to the tumor. These proteins are vascular growth factors like VEGF -- the target for the anti-cancer drug Avastin. Making these proteins requires the slotting together of different parts of genes, a process called splicing.Scientists at the University of West England and the University of Bristol discovered that mutations in one specific cancer gene can control how splicing is balanced, allowing a master switch in the cell to be turned on. This master switch of splicing makes cancer cells grow faster, and blood vessels to grow more quickly, as they alter how VEGFs are put together.In experimental models, the researchers found that by using new drugs that block this master switch they prevented blood vessel growth and stopped the growth of cancers."The research clearly demonstrates that it may be possible to block tumor growth by targeting and manipulating alternative splicing in patients, adding to the increasingly wide armory of potential anti-cancer therapies," the authors said.

来源：资阳报