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WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.

Beijing, Sept. 13 (Xinhuanet) -- A fear of taking antidepressants often results in people's reluctance of going to see the doctor when they are suffering from depression, a study find.The finding was published Monday in the U.S. journal Annals of Family Medicine.The researchers from the University of California investigated 1,054 adults on why they wouldn't tell the doctors about their depression symptoms, as well as any possible mental disorder.Among the participants, 43 percent admitted that they had been reluctant to tell the doctor about their depression symptoms.Their top concern was the possibility of being prescribed an antidepressant -- a worry voiced by 23 percent of the whole study group.Another 16 percent thought dealing with "emotional issues" is not the doctor's job. And a similar percentage worried that the diagnosis of depression may leave a negative record on their medical records.The study would be helpful for looking into the reasons that patients harbor the attitudes that they do, said Dr. Hellerstein of the New York State Psychiatric Institute and Columbia University Medical Center in New York.

BEIJING, July 27 (Xinhuanet) -- Amazon.com’s e-book reader Kindle 3G with special offers is now the company’s top-selling e-book device, according to media reports on Wednesday.Amazon revealed in its quarterly earnings report that the ad-supported version costs 139 U.S. dollars,  50 dollars cheaper than the comparable Kindle 3G, and costs the same as a Kindle with Wi-Fi connectivity. Many believe Kindle is the most popular dedicated e-book device on the market today.The advertisements will appear only in screensavers (which appear when the reader is in an idle state) and at the bottom of the home screen, so they don’t interrupt readers.“Since AT&T agreed to sponsor screensavers, Kindle 3G with Special Offers is now our bestselling Kindle device,” Amazon’s press release said.Having zoomed past the earlier Sony Reader, and kicked off a wave of competition including the Barnes & Noble Nook and the Kobo E-Reader, Kindle is believed the most popular dedicated e-book device on the market today.

He also said that China's track record of sharing knowledge with the World Bank was creating a "catalyst for consensus" and that placed the institutions in good stead to benefit from China's economic consistence."The Chinese policy mix includes a tool box of administrative measures ... In general, one of the lessons that the United States and others can learn (from China) is that to have supervisory policies for bank regulatory systems can be a useful part of the tool set."Aside from hinting that over-heating global real estate markets could benefit from China's regulatory tightening, Zoellick suggested if China moved to more market-exposed decision making, he hoped China's bank regulators would not step too far back."Over time China will be better served to move to more precise and market signals than more administration-based decisions. Over time China will want to move to more market based decisions ... but I don't want this to be interpreted that supervisors don't have to supervise," he said.

来源：资阳报