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WASHINGTON, April 11 (Xinhua) -- In the first clinical trial of gene therapy for treatment of intractable pain, U.S. researchers from the University of Michigan's Department of Neurology observed that the treatment appears to be able to provide substantial pain relief.In a study published online in the Annals of Neurology and seen on Monday, the researchers showed that the novel agent NP2 is safe and well-tolerated. In addition, measures of pain in the treated patients suggested that NP2 may provide a substantial analgesic effect.NP2 is a gene transfer vector that expresses the naturally- occurring opioid peptide enkephalin. In preclinical work in animals, David Fink, chair of the Department of Neurology, and his coworkers had demonstrated that injection of NP2 into the skin reduces pain in models of pain caused by nerve damage, inflammation or cancer.In the clinical trial, 10 patients with unrelenting pain caused by cancer were injected with the gene transfer agent in the area of skin related to the location of pain."The concept underlying this therapeutic approach is that injection of NP2 into the skin results in uptake into the nervous system and the production and release of a pain-relieving chemical in a controlled site in the pain pathway," says Fink. "In the study, patients who received the low dose of vector showed little reduction in pain; patients receiving the higher doses showed a greater than 80 percent reduction in pain over the course of four weeks following treatment."Fink's laboratory has been working on the use of modified herpes simplex virus-based vectors that are taken up by sensory nerves following skin injection to develop therapies for diseases of the nervous system for more than 20 years. Patents related to this technology have been exclusively licensed by Diamyd Medical, a publicly-traded Swedish biotechnology company that sponsored the trial, and the human-grade vector NP2 was produced by Diamyd, Inc, the U.S. subsidiary of Diamyd Medical.A phase 2 trial to compare NP2 to a placebo control has already been initiated under sponsorship from Diamyd.

BEIJING, Jan. 25 (Xinhua) -- A book collecting speeches made by Chinese President Hu Jintao during his state visit to the United States earlier this month has been published by the People's Publishing House.The book was distributed by Xinhua Bookstores Tuesday.
BEIJING, March 19 (Xinhua) -- In spite of the fact that snow still covers his farmland, Jiang Chen has been busy stocking fertilizers and seeds to prepare for the coming spring farming season."I am almost ready for the sowing," said Jiang, a 64-year-old peasant who farms five hectares of cropland in Liujia Township in Yushu City, northeast China's Jilin Province. "But the costs are rising so I still want to look for better seeds providing a higher yield this year."As the Chinese government continued policies to assure a good grain harvest this year, millions of farmers like Jiang in China's major grain-producing regions such as Jilin, Heilongjiang, Shandong and Henan provinces are now gearing up to finalize preparations for the coming sowing season.The central government's incentives in 2011 include increases in minimum rice purchase prices by 9.7 percent to 21.9 percent from last year, as well as 24.9 billion yuan (about 3.77 billion U.S. dollars) in subsidies to the national grain risk fund for farmers."Though farmers are richer now than before, our economic strength remains relatively weak as compared with urban residents," Jiang said.He noted that he was considering investing less this year because the cost of agricultural production has increased year after year.The average urea price from manufacturers and retailers rose about 10 percent from last year to about 1,980 yuan and 2,100 yuan per tonne at a grain and oil wholesale market near Yuquan Road in Beijing, where many farmers from neighboring Hebei, Henan and Shandong provinces buy agricultural fertilizers and additives.Urea is the primary fertilizer used by Chinese grain growers, though many of the farmers said that they would reduce the use the compound in their fields due to rising prices and the impact on wheat caused by the widespread drought in north China this winter.Wang Quan, the president of China National Agricultural Means of Production Group Corp., the country's largest supplier of agricultural materials, predicted that the use of urea during the spring farming season would be between 20 million tonnes to 25 million tonnes, which is about two fifths of the year's total.Wang said that the urea price is around 400 U.S. dollars per tonne in global markets, or 15.7 percent higher than the domestic price."I think it takes time for Chinese farmers to accept the price hikes gradually," he added.Analysts say that the different perceptions on urea prices between manufacturers and farmers may have affected China's crops because the reduced use of fertilizers usually mean less grain output in the country since many farmers depend more on fertilizers, rather than technology to boost production.China's grain output rose 2.9 percent last year to 546.41 million tonnes, marking the seventh consecutive year of growth. The country aims to keep its 2011 grain production over 500 million tonnes, according to an executive meeting of the State Council, or the Cabinet, Thursday.Chinese Premier Wen Jiabao said last month that rising costs of grain production, the lingering drought in north China's major wheat-growing regions and the weakening of agricultural production in some areas would directly affect China's summer grain output.Facing challenges such as higher costs for growing grain, Jiang believed that he could generate higher income from his crops this year with the support of the agricultural sector by the government."If the grain prices also rise this year, I can still earn a net income of 10,000 yuan for every hectare of farmland," Jiang said."I hope to keep my farmland from being seized for industrial or residential development," he added.
TAIPEI, Jan. 29 (Xinhua) -- Nora Sun, granddaughter of Sun Yat-sen, the forerunner of China's revolution to end feudalism, died Saturday afternoon in a Taipei hospital, about one month after being injured in a car accident.Sun, 72, was severely injured in a car crash while on her way to an airport near Taipei on Jan. 1. She was in stable condition after several operations, but her condition abruptly deteriorated Saturday afternoon, according to hospital officials, without giving additional details.Sun, who spent most of her time in Shanghai, came to Taipei to attend the Flora Expo. While returning to Taoyuan International Airport near Taipei the black sedan Sun was riding in crashed head-on into an oncoming vehicle, described as a red car. Sun had planned to return to Hong Kong that day.Sun's car had been driven by a friend. The driver of the red car, who was believed to be speeding, according to police, died on the spot. Sun, her friend, and an injured passenger in the red car were immediately transported to a hospital. .Sun is the youngest daughter of Sun Fo, son of Sun Yat-sen, the leader of the 1911 Revolution that ended imperial rule in China.
来源:资阳报