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WASHINGTON, July 15 (Xinhua) -- Researchers at Mount Sinai School of Medicine have found that grape seed polyphenols -- a natural antioxidant -- may help prevent the development or delay the progression of Alzheimer's disease.The research, led by Giulio Pasinetti, was published online Friday in the Journal of Alzheimer's Disease, which causes brain changes that gradually get worse.This is the first study to evaluate the ability of grape- derived polyphenols to prevent the generation of a specific form of amyloid (A) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer's disease.In partnership with a team at the University of Minnesota, Pasinetti and collaborators administered grape seed polyphenolic extracts to mice genetically determined to develop memory deficits and A neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the A*56, a specific form of A previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment.Previous studies suggest that increased consumption of grape- derived polyphenols, whose content, for example, is very high in red wine, may protect against cognitive decline in Alzheimer's. This new finding corroborates those theories."Since naturally occurring polyphenols are also generally commercially available as nutritional supplements and have negligible adverse events even after prolonged periods of treatment, this new finding holds significant promise as a preventive method or treatment, and is being tested in translational studies in Alzheimer's disease patients," said Pasinetti.In Alzheimer's disease, brain cells degenerate and die, causing a steady decline in memory and mental function.
BEIJING, Sep. 1 (Xinhuanet) -- Apple lost another iPhone prototype at a Bay Area bar, according to media reports Thursday.It is reported that an Apple employee lost a prototype iPhone at San Francisco bar Cava 22 in late July, which is a tequila bar in the mission district.A joint investigation by Apple and San Francisco police searched a local house but could not find it, the reports added.It seems that Apple employees learned nothing from last year’s lost iPhone scandal. A prototype iPhone 4 was lost in a Redwood City bar last year.Apple has denied any knowledge of the incident, and San Francisco police stated that Apple did not file a police report for the lost merchandise.If the reports are true, it would be a big blow to Apple’s ego since the company takes pride in its secretive nature.
BERLIN, June 10 (Xinhua) -- The German state of North Rhine-Westphalia said Friday it detected for the first time the deadly E.coli strain o104 on bean sprouts, after they were named the source of the outbreak by Germany's national disease control centre. "According to our knowledge, the bean sprouts are coming from the recent suspicious farm in Bienenbuettel in the state of Lower Saxony," said Johannes Remmel, consumer protection minister.The sprouts were found in an opened package which had been left in a dustbin of a family, living near the city of Bonn. Two of the family members had eaten the sprouts and contracted the E. coli infection in mid-May, he said.A notice warning consumers not to eat raw bean sprouts is seen at a market in Berlin, capital of Germany, June 10, 2011. The German authority said on Friday bean sprouts were probably the source of the E. coli outbreak, which has killed 30 people and infected about 3,000 around the world. Reinhard Burger, president of the Robert Koch Institute (RKI), Germany's national disease control center said the Robert Koch Institute was lifting its warning against eating cucumbers, tomatoes and lettuce but keeping the warning in place for the sprouts."The discovery confirms our current warning against the consumption of bean sprouts. It is therefore becoming increasingly more likely that bean sprouts are the source of the E.coli infections," Remmel said.The news came after Reinhard Burger, President of the Robert Koch Institute (RKI), said in the morning bean sprouts were the source for the outbreak based on a epidemiological investigation."People who ate (bean) sprouts were found nine times more likely to have bloody diarrhoea or other signs of E. coli infection than those who did not," he saidHowever, no sample tests had found the o104 strain on bean sprouts when he announced that conclusion. Laboratory tests have shown Germany made mistakes in identifying the outbreak source on two previous occasions.At the same time, RKI lifted the warning against cucumbers, tomatoes and lettuce."Enjoy lettuce, cucumbers and tomatoes. They are healthy for you," said Andreas Hensel, president of the German Federal Risk Assessment Institute (BFR), which is a co-leader in the action against E. coli.In the city of Hamburg, an epicentre for the disease, farmers protested in the city centre by offering tons of lettuce and cucumbers for free to anyone who wanted them when the news was announced. Suddenly, pedestrians turned from reluctant to eager takers, reported local news agency DPA.
WASHINGTON, June 8 (Xinhua) -- Hundreds of small genetic variations are associated with autism spectrum disorders, including an area of DNA that may be a key to understanding why humans are social animals, according to a multi-site collaborative study led by researchers at Yale University.To be published Thursday in the journal Neuron, the study reinforces the theory that autism, a disorder that develops in early childhood involving impairments in social interaction, language deficits and distinctive behaviors, is not caused by one or two major genetic defects, but by many small variations, each associated with a small percentage of cases.The study looked at more than 1,000 families in which there was a single child with an autism spectrum disorder, an unaffected sibling and unaffected parents. The team compared individuals with autism to their siblings to determine what types of genetic changes distinguished the affected child from the unaffected child.One of the most intriguing of these findings points to the same small section of the genome that causes Williams syndrome -- a developmental disorder marked by high sociability and an unusual aptitude for music.In autism, there is an increase in the chromosomal material, an extra copy of this region, and in Williams syndrome, there's a loss of that same material," said lead author Matthew State. "What makes this observation particularly interesting is that Williams syndrome is known for a personality type that is highly empathetic, social, and sensitive to the emotional state of others. Individuals with autism often have difficulties in the opposite direction. This suggests that there is an important key in that region to understanding the nature of the social brain."State and his team also found about 30 other regions in the genome that are very likely contributing to autism and are focused on about six of those regions that showed the strongest evidence."We're now moving on to a second phase of the study looking at an additional 1,600 families and should be able to identify multiple new regions that are strongly implicated in autism," he said.