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WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.
BEIJING, March 22 (Xinhuanet) -- NASA scientists are testing its next-generation Mars rover, which will land on Mars next year, under extreme conditions at space-simulation chamber in California, media reports said Tuesday.Scientists at NASA's Jet Propulsion Laboratory in Pasadena, Calif., say they've installed the Curiosity rover in a space-simulation chamber that can mimic the environment the probe will encounter on Mars. After the chamber's large door was sealed last week, air was pumped out to near-vacuum pressure, liquid nitrogen in the walls dropped the temperature to minus 130 degrees Celsius, and a bank of powerful lamps simulated the intensity of sunshine on Mars.After the test period, the rover along with other portions of NASA's Mars Science Laboratory spacecraft including the cruise stage, descent stage and backshell -- part of protective covering -- will be shipped to the Kennedy Space Center for final preparation for the launch window from Nov. 25 to Dec. 18, 2011. Curiosity will study whether a selected area of Mars has offered environmental conditions favorable for microbial life and for preserving evidence about whether Martian life has existed.
KUNMING, March 13 (Xinhua) -- Local authorities said all earthquake victims had found shelter after nearly 9,000 tents were set up in the earthquake-hit Yingjiang County in southwest China.Altogether 53,000 people are being housed in large-sized tents erected in county plazas and village squares, said Jiang Zhaogang, spokesman with the rescue headquarters.Others moved in with friends, relatives, or makeshift houses for temporary accommodation, said Jiang.A 5.8-magnitude quake struck Yingjiang County in southwest China's Yunnan Province Thursday, leaving 25 dead and 314 injured. The tremor also toppled the homes of 1,039 families and left 4,994 others seriously damaged.As of Sunday, the central and local governments in Yunnan have disbursed 10,000 tents, 15,000 quilts and 15,000 coats for the homeless victims in the quake-hit region.White coated medical personnel patrolled and disinfected the tents every day, and no sign of epidemics have been detected.In one tent area, a local medical team was brewing traditional herbal juice for disease prevention, while residents lined up before the steaming wok with bowls, bottles, and even wash basins at hand."I invented this herbal brew especially for the disaster victims, which can help prevent flu and alleviate rheumatic pains," said Chen Benshan, an experienced practitioner of traditional Chinese medicine.Though the rebuilding of the county has not been put on schedule, less damaged schools are expected to resume classes on Monday."We want to start counseling classes as soon as possible to help the children recover from the terror of the earthquake," said Jin Xiasi, a member of the local rescue team.
VIENNA, March 28 (Xinhua) -- Stress hormone is helpful in alleviating acrophobia, a morbid fear of great heights, according to a study by Austrian scientists.They published the findings in the recent Proceedings of the National Academy of Sciences of the United States of America.Frank H. Wilhelm, professor from the Department of Clinical Psychology, Psychotherapy and Health Psychology at the University of Salzburg, Austria, carried out the first study demonstrating the clinical effectiveness of hormones released at periods of high stress in anxiety.The study found hormones and other drugs could be a good addition to behavioral treatment of several anxiety disorders.People with acrophobia have formed a so-called fear memory, which could be activated when the fear-causing stimulus occurs. They tend to react with feelings of extreme fear and anxiety to the ride in a glass elevator.Hence, scientists conducted a confrontation therapy, trying to mask this memory.A total of 40 experimental subjects had been put in a safe environment to constantly confront the fear-inducing stimulus, until they had a new reaction to the perceived threat.Observations also suggested hormones released in high stress had impact on learning and memory.Additionally, stress hormones were believed to facilitate the storage of new, anxiety-free competence and experienced confidence in the therapy. Animal studies have shown that this emotional relearning benefits from cortisol, one of the stress hormones.
HARARE, Feb. 11 (Xinhua) -- Chinese Foreign Minister Yang Jiechi on Friday called on the West to lift sanctions they imposed on Zimbabwe while Zimbabwean President Robert Mugabe applauded the Asian giant for its continued political and economic support.Addressing journalists soon after meeting Zimbabwe President Mugabe, Yang, who is on a two-day visit, said Zimbabweans and other African people have a right to choose their own development path."We believe there should be the lifting of sanctions by certain countries. We think that is the voice of the Zimbabwean people and that is also the view of all the parties concerned here in Zimbabwe," Yang said, adding that no country has a right to dictate to another."We believe all nations should respect each others sovereignty and territorial integrity," he said."China believes that Africans have the right to choose their own way of development as they are the masters of the African continent. All others are just guests," he said.Yang said that China appreciates assistance from Africa and would also continue to reciprocate the support.Addressing the Chinese delegation earlier, Zimbabwean President Mugabe said the West continues to persecute Zimbabwe through sanctions for the decision the county took to empower its people through land.He said the imposition of sanctions was despite the fact that Zimbabwe and Britain had agreed that the former would redistribute the land while the latter would compensate affected farmers."The Western countries have imposed sanctions on us for taking our land although we had discussed this in 1979. That is what started the problem," Mugabe said.Mugabe said Britain had since turned to political reasons such as human rights, democracy and rule of law to justify continued sanctions imposed on Zimbabwe.He applauded continued cooperation between China and Zimbabwe which dates back to the struggle for independence.Meanwhile, China extended a 50 million yuan (7.5 million U.S. dollars) grant to Zimbabwe.Yang and his Zimbabwean counterpart Simbarashe Mumbengegwi signed the agreement on behalf of their countries.In his meeting with Mumbengegwi, Yang who described Zimbabwe as a "brother" said the two countries had identified areas for further cooperation such as infrastructure, agriculture, water conversation and personnel training.