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The year's race for Kansas governor has the second-largest field since 1908 — seven Republicans and five Democrats are on the ballot.With a field so large, candidates are now paying for more ads on TV and launching bus tours. It's an effort to win your vote for the primary.University of Kansas political science professor Patrick Miller said the crowded field could be the reason why some candidates and their running mates are taking unconventional measures. Specifically, using their own money to self-fund their campaigns."A lot of big donors want to support the party and they don't want to intervene in the primaries," said Miller.Independent Greg Orman has spent 0,000 of his own money on his campaign.Republican Secretary of State Kris Kobach's running mate, Wink Hartman, has given or loaned the campaign more than .5 million."It is bizarrely unusual. Extraordinary unusual," said Miller.The crowded field, Miller said, could also have an impact on how many votes a candidate gets —especially on the Republican side.Gov. Jeff Colyer has launched an ad campaign, warning voters "a vote for [Ken Selzer, Jim Barnett or Patrick Kucera] is essentially a vote for Kris Kobach."These candidates are sometimes referred to as spoiler candidates, who draw votes from a major candidate with similar politics and could cause a strong opponent to consequently win.Miller said this happened in the 2016 presidential election with Jill Stein taking voters away from Hillary Clinton."In the primary you have four or five candidates splitting the vote, who are all generally conservative," he said, agreeing this could give Kobach an advantage. "If you don't like his personality or his controversy, you might go vote for Jeff Colyer, who is less controversial, or Ken Selzer, Jim Barnett or any of the other candidates.As the days get closer to primary day, Miller said to expect more knocks at the door, fliers, ads to air on TV and on the radio and so forth.He said the candidate's final push won't necessarily be about issues but rather their personalities and stylistic differences that separate them from the others."In the primaries, that matters," he said. 2170

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

TIJUANA, Mexico (KGTV) - The first group of people from the migrant caravan have arrived in Tijuana, according to a Mexican journalist. According to journalist Jorge Nieto, the group has 85 people. This group is reportedly people of the LGBTQ+ community and they left the others behind because they felt they were being discriminated against. They arrived at the Tijuana bus station, then took buses to an Airbnb in Playas de Tijuana, paid for by U.S. lawyers with the caravan.RELATED: Bulk of migrant caravan is 1,600 miles away from TijuanaOnce at the house, neighbors clashed with the migrants, "Yelling at them go away go to a shelter, this is not your place, all you came here this is a safe area and we are afraid of you," Nieto said shelters aren't an option as they are already over capacity from the last caravan.Nieto said the migrants defended themselves, saying the neighbors could hurt them as well, "we're not going to make noise, we're not going to make any mess."One migrant spoke with reporters saying they had the right to seek refuge in another country and pursue a better life with respect.It's not clear when they plan to turn themselves into U.S. Customs and Border Protection (CBP) and seek asylum in the United States.The group will reportedly spend a few days in Tijuana to rest. RELATED: Interactive Map: Migrant caravan journeys to U.S.-Mexico border / Timeline: Migrant caravan travels to border / Photos: Migrant caravan makes its way to border 1531

Tijuana, B.C. (KGTV) — As Christmas approaches, decorations are up around Tijuana but much of the city has shut down. According to ABC 10News’ media partner Televisa, the state of Baja California has had almost 27,000 COVID-19 cases and nearly 5,000 deaths since the start of the pandemic.For comparison, San Diego County's had startling 97,549 cases but far fewer deaths. As of Thursday, 1,103 deaths had been reported.On Thursday morning, ABC 10News spoke to Televisa anchor Estephania Báez about how hospital capacities across the border are maxed out, pulling the city out of its less restrictive orange tier and back into its most restrictive red tier. That hasn’t happened since the summer.“The difference between now and then is that now people don't have fear with COVID-19 here and [people have] to go to work so they prefer to [become] positive rather than to lose a day of money,” she added.Baez said there's concern over both apathies to wearing masks and resistance to any news of a vaccine. “They don't even want to get vaccinated. We have heard in several places that people are afraid and they don't trust even the authorities,” she told ABC 10News.Baja California's red tier restrictions are in place through at least Dec. 20, meaning widespread closures. “That includes schools, gyms, spas, museums, pools, movie theaters, churches, and amusement parks,” said Baez. Restaurants and hotels can operate at a very limited capacity.Televisa also reports that the high cost of testing and limited locations to get testing done continues to be a deterrent for many people. 1592

There is growing concern within the US military about the costs of President Donald Trump's proposed military parade and the disruption it could cause.If Trump insists on a military parade through Washington involving thousands of troops, armored vehicles, missiles and other heavy weapons the event could disrupt crucial military training schedules, according to a defense official directly familiar with the initial planning efforts.There are also concerns over the cost of the event, and a second defense official tells CNN that the Pentagon is considering seeking out private donations to offset some of the non-military costs of the event. The donations could not cover military salaries or the cost of moving equipment but they could be used to pay for other aspects of the parade.There are no firm cost estimates until President Trump orders the military to stage a specific event, but very preliminary estimates suggest the cost could run between million and million, the first official said, emphasizing that nothing is certain at this point. There is no money currently allocated for a parade in the defense budget. Budget director Mick Mulvaney said Wednesday that he has seen estimates that a military parade could cost million to million.On wider concerns about a large scale parade, "we don't have troops and units sitting around waiting to do a parade," the first defense official said. A large parade could require weeks of preparation, including the early shipment of equipment such as tanks, and personnel would need to arrive days ahead to be ready to man the gear during a parade.One solution being considered to alleviate that concern is a so-called multimedia option, which could include a concert and large video screens on the National Mall displaying images of military gear rather than bringing large amounts of hardware to Washington, the official said.The Army, which is in charge of developing options for a parade or celebratory event, has compiled five preliminary options that have been forwarded to Pentagon leadership.The initial options are broadly characterized as "small, medium, heavy, hybrid and a multimedia display." Each could be fine-tuned to meet specific requests by Trump.The small and medium options could include varying levels of troops marching from ceremonial units stationed in Washington and some equipment located nearby from the Maryland and Virginia National Guard.The so-called heavy option would bring active duty units to Washington. Generally, all active duty units that are not deployed have ongoing and regular stateside training and exercise commitments that may have to be halted if they were involved in a parade.According to the official, one indicator of the Pentagon's lack of enthusiasm for the project is that the Defense Department told the Army to include a significant amount of aircraft in the ceremony to mitigate the burden on ground forces.The Pentagon is not commenting on potential options. Chief spokesperson Dana White told CNN her previous public comments still stand. On February 8 she told reporters, "We're still in the nascent stages. When we have those options, we will provide that to the White House, and the President will decide. "Defense Secretary James Mattis and Gen. Joseph Dunford, chairman of the Joint Chiefs of Staff, have publicly said the department will develop options to address the President's request for a parade. Trump brought up the matter after seeing France's Bastille Day celebrations in Paris last year but did not specify what he wanted.Pentagon officials have previously indicated they may look to schedule an event on November 11, which is Veterans Day. This year is the 100th anniversary of the end of World War I.Several commemorations are already planned in Europe with US forces participating. One advantage of holding the event Trump wants in November is that with cooler weather, there is less potential for damage to city streets from heavy equipment being driven on them.The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 4114