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CLEVELAND — Scientists at the Cleveland Clinic Lerner Research Institute have successfully reversed Alzheimer's disease in mice.According to a news release, the researchers reversed the formation of harmful plaque in the mice's brains by gradually reducing an enzyme called BACE1, improving their mental function.“To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer’s disease mouse models,” says Riqiang Yan, one of the scientists on the team. The study raises hopes that drugs aimed at this same enzyme will soon be able to treat Alzheimer's disease in humans. You can read the full study in the Journal of Experimental Medicine here. 735
CLEVELAND — After the team announced it will be changing its name, Cleveland Indians owner Paul Dolan sent a letter to fans addressing the decision.Dolan said that as a fifth-generation Clevelander, he understands the impact and importance of the decision to change the name. He said while many fans may be upset that the team they grew up with will soon have a different name, the most important part of the team isn’t changing."Like many of you, I grew up with this name and have many great memories of past Indians teams: the World Series appearances, Cy Young winners, the longest win streak in MLB history, and countless other unforgettable moments that brought our team, fans, and community together,” Dolan wrote. “These memories will forever stay in our hearts, minds, and record books, and we will continue to recognize our ball club’s remarkable legacy. While I have often associated these unforgettable memories with the name Indians, I sincerely believe Cleveland is the most important part of our team name.”Dolan credited the team’s progressive history and said the decision to change the name only helps keep up with the organization’s high standard.“Ultimately, we found our organization is at its best when we can unify our community and bring people together around our shared interest in our home team – and we believe a new name will allow us to do this more fully,” Dolan wrote. “We often celebrate being the first team in the American League to have an African American player in Larry Doby and the first African American manager in Frank Robinson. These forward-thinking acts by our predecessors have helped shaped our team and community, and today’s decision helps us continue to live up to these high standards and expectations.”When the team announced the decision to change the name, it was made clear that this was not going to happen overnight and that while the process is ongoing, Cleveland’s baseball team will still go by the “Indians.”“Our decision to change the current name is phase one of a multi-phased process. Future decisions, including the new name and brand development, are complex and will take time. We believe our new name will take us into the future and proudly represent this storied franchise for decades and generations to come. In light of the importance, we will not rush these decisions,” Dolan wrote to fans.Dolan ended his letter to fans thanking them for their support and said his love for baseball and the city of Cleveland is a driving force behind his belief that the organization can make a “positive impact within our city to unite and inspire those around us to do the same.”Read his full letter to fans below: 2683

CINCINNATI — Ringed by neurosurgeons in sky-blue scrubs, masks and magnifying loupes, Makenzi Alley lay on a Jewish Hospital operating table and smiled. Her brain glistened pink and purple under the electrode they used to cautiously probe it; sharper implements awaiting their turn in the procedure shone nearby.At Dr. Vincent DiNapoli's signal, Alley began to speak. The team went to work.Wide-awake brain surgery might sound like a nightmare to many, but it was the only way doctors at Jewish Hospital's Brain Tumor Center could remove the tumor that had stolen Alley's sense of taste without damaging the vital tissue nearby."Of all the places to pick, it's kind of right in the spot you wouldn't want it to be," DiNapoli said, gesturing to a scan of Alley's brain in which the tumor stood out as a circular mass of solid white.Even a slight mistake could permanently rob her of her ability to produce spoken or written language — and, if she were fully anesthetized, her team might not know until she woke up."I knew he needed me to talk to do his best job, so I talked the whole time," Alley said months later, laughing. "There was never a time where I was like, ‘We need to stop,' and I started freaking out. It was very smooth. Very simple."DiNapoli's team used the electrode, her scans and her ongoing conversation as mapping tools. When she stopped talking, they knew they had touched the Broca area — the region of the brain that controls speech production — and needed to proceed carefully.The tumor they removed from Alley's brain was the size of a golf ball, she said. With it went the stutter she had developed as it pressed on her speech center; in its absence, her sense of taste returned.She was also able to return to the pastimes she loves, including playing guitar, studying and running competitively."That was actually an emotional sight to me," her mother, Traci Alley, said Thursday. She cradled her phone in her hand, displaying a picture of Alley smiling midway through a race. "She did so well. I wasn't sure I'd see her running again." 2095
Commercial real estate leader Steve Schwab is looking to sign tenants to leases at a new development in downtown Denver but he’s running into troubles linked to the pandemic.“COVID has a had a major effect, probably the most major effect in the sales business,” he said.Schwab, a managing principal at Cushman & Wakefield, says COVID-19 has had a major impact on commercial real estate in a short amount of time.“Between the first quarter and the second quarter, we saw office investments sales decrease by about 72%,” he said.Schwab says unemployment, more people working from home and social distancing are impacting commercial real estate sectors like shopping centers, hotels, retail and office spaces.He says that the road to recovery will be very challenging, something other industry experts agree with.“The restaurants, the gyms, the bowling alleys, those are going to struggle over the next 12-18 months until we get back to full physical occupancy,” said Spencer Levy, chairman at CBRE.Levy says high inventory combined with low interest rates could attract foreign investors to American commercial real estate, something he welcomes with open arms.“Foreign money isn’t just cash. It brings everything with it. It brings jobs, it brings foreign students, it brings people that buy retail,” he said.But will foreign investment bring more people back inside massive buildings?Levy compares what today's commercial real estate industry needs to rebound to that of 9/11.“We had a period of time where people were tragically afraid to be back in the cities, afraid to go back into tall buildings. But that passed after people had better security in those buildings,” he said. “We are going to see exactly the same thing today from a wellness prospective.”With many major retailers already moving out of brick and mortar buildings, and millions of square feet available across the country, Levy says the commercial real estate industry needs more government assistance on the road to recovery. 2005
Creed frontman Scott Stapp will be adding “actor” to his resume, joining the cast of an upcoming biographical movie about Ronald Reagan.Stapp will be playing Frank Sinatra in the movie, Billboard first reported and Stapp confirmed on his twitter account.“Excited to (be) a part of this incredible film! Be sure to check it out!” Stapp tweeted along with a hashtag of Reagan and Frank Sinatra, and linking to the Billboard story. 436
来源:资阳报