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LOS ANGELES (AP) — Arnold Spielberg, father of director Steven Spielberg and a pioneering computer engineer, has died. A family statement says Spielberg died Tuesday in Los Angeles at 103. He co-designed the GE-225 mainframe computer while working for General Electric in the 1950s. The machine allowed researchers at Dartmouth College to come up with the coding language BASIC, which made personal computers possible. Spielberg tried to get his son into engineering but said he could tell his heart was in the movies, and he helped him make his first full-length film, “Firelight,” when the future director was 16. 623

LONDON — U.K. regulators say people who have a “significant history’’ of allergic reactions shouldn’t receive the new Pfizer-BioNTech vaccine while they investigate two adverse reactions that occurred on the first day of the country’s mass vaccination program. Stephen Powis, the national medical director for the U.K.'s National Health Service in England said Wednesday that health authorities were acting on a recommendation from the Medical and Healthcare Products Regulatory Agency. He says the agency has advised, on a precautionary basis, that "people with a significant history of allergic reactions do not receive this vaccination." Powis added that both people are recovering well.Dr. June Raine, head of the U.K.'s Medical and Healthcare Products Regulatory Agency, told Parliament on Wednesday that the reactions were not seen in clinical trials for the drug.“We know from the very extensive clinical trials that this wasn’t a feature,” Raine said, according to the Associated Press. “But If we need to strengthen our advice, now that we have had this experience with the vulnerable populations, the groups who have been selected as a priority, we get that advice to the field immediately.The FDA is currently weighing whether to approve the Pfizer-BioNTech vaccine for emergency use in the United States. 1325

LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959

LOS ANGELES (CNS) - Los Angeles County has reported 5,014 new cases of COVID-19 and 16 additional deaths, bringing the county's totals to 395,843 cases and 7,639 deaths as sweeping new health orders intended to halt the recent surge in cases go into effect.The number of county residents hospitalized with the virus rose from 1,951 Saturday to 2,049 Sunday, surpassing the 2,000 mark for the first time since the summer. Of those hospitalized, 24% are in intensive care.Health officials are urging people to stay at home as much as possible over the next three weeks."We have done this successfully before and we can do it again," County Public Health Director Barbara Ferrer said of efforts to stem the surge in new cases, deaths and hospitalizations.The new measures that go into effect Monday will remain until at least Dec. 20, according to the Los Angeles County Public Health Department.The additional safety modifications include the following changes to the existing Health Officer Order:-- Gatherings: all public and private gatherings with individuals not in your household are prohibited, except for church services and protests, which are constitutionally protected rights.-- Occupancy limits at various businesses; all individuals at these sites are required to wear face coverings and keep at least 6 feet of distance from others:-- Essential retail: 35% maximum occupancy;-- Nonessential retail (includes indoor malls): 20% maximum occupancy;-- Personal care services: 20% maximum occupancy;-- Libraries: 20% maximum occupancy;-- Fitness centers operating outdoors: 50% maximum occupancy;-- Museums galleries, zoos, aquariums, botanical gardens operating outdoors: 50% maximum occupancy;-- Mini-golf, batting cages, go-kart racing operating outdoors: 50% maximum occupancy;-- Outdoor recreation activities all require face coverings (except for swimming) and distancing: Beaches, trails and parks remain open; gatherings at these sites with members outside your household are prohibited. Golf courses, tennis courts, pickleball, archery ranges, skate parks, bike parks and community gardens remain open for individuals or members of a single household. Pools that serve more than one household may open only for regulated lap swimming with one person per lane. Drive-in movies/events/car parades are permitted provided occupants in each car are members of one household.-- Schools: All schools and day camps remain open adhering to reopening protocols. K-12 Schools and Day Camps with an outbreak (3 cases or more over 14 days) should close for 14 days.-- Closed nonessential businesses/activities: Playgrounds (with the exception of playgrounds at childcare centers and schools; card rooms;-- Restaurants, bars, breweries and wineries remain closed for in- person dining and drinking because of the high rates of transmission in the community, as customers are not wearing face coverings, which results in an increased chance of transmission of the virus.-- Restaurants, wineries and breweries remain open for pick-up, delivery and take-out. Breweries and wineries remain open for retail sales at 20% occupancy.Ferrer said Saturday the protocols for professional sports teams in the county would not change. "They are and will remain spectator-free."As for college sports, "We align with the state's collegiate sports directive. Should the state change, we at the local level will change."Ferrer said officials knew this surge was coming, but "None of us really thought the increase would be so big, across such a short period of time."She added that with a vaccine expected to be approved for distribution shortly, "the light is there at the end of the tunnel ... but we've got to get there."According to county estimates released earlier this week, every COVID- 19 patient in the county is passing the virus to an average of 1.27 people -- the highest transmission rate the county has seen since March, before any safety protocols such as face coverings and social distancing were in place.Based on that transmission rate, health officials estimate one of every 145 people in the county are now infected with the virus and transmitting it to others."This doesn't include people that are currently hospitalized or isolated at home," county Health Services Director Dr. Christina Ghaly said. "This is the estimate of people that are out and about and infecting others. They may not know they're infected. They may know they're infected and not be isolating. But they're out there and they're exposing other people to the virus."Ghaly said the number of people hospitalized due to the virus has jumped by 70% in the past two weeks, with the county now averaging about 300 new admissions daily."Based on the current estimate for (the virus transmission rate) and assuming that there's no change in people's behavior that would affect transmissions, there will likely be shortages in the number of hospital beds, and especially in ICU beds or intensive-care unit beds, over the next two to four weeks," she said.Ghaly noted that given the current transmission rate, the number of hospitalized patients could double in two weeks, and quadruple in a month. She said hospitals have "surge" plans to increase the number of beds, but the availability of health care workers to staff those beds and treat patients is more limited. 5345

LONDON – British actress Diana Rigg has died at the age of 82.Rigg’s agent told the BBC the Associated Press that the actress died peacefully at her home Thursday morning, surrounded by family members who have asked for privacy.The agent did not disclose a cause of death.Rigg was known for her television roles. Recently, she played Olenna Tyrell on the hit HBO drama “Game of Thrones” and she portrayed Emma Peel in the 1960s show “The Avengers,” which aired on ITV.Rigg also starred in the James Bond film “On her Majesty’s Secret Service,” in which she played the only woman to ever marry 007.The actress also had a successful career in theater, winning the 1994 Tony Award for Best Actress in a Play for her work in “Medea.”Rigg was made a Commander of the Order of the British Empire in 1988 and a Dame in 1994 for her services to drama. 851