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SAN DIEGO (KGTV) — Looking for a laugh? It is, after all, the best medicine, right?There's plenty of belly shaking humor to be discovered around San Diego. From open mic nights to nationally-known comics being showcased, locals can find it all at our city's comedy clubs.If you're looking for a spot to sit down, have a drink, and spit-take that drink, here's where you'll find the fun around town:The American Comedy Co.: 818 B 6th Ave., San DiegoAMC is located in the heart of the Gaslamp District, giving guests to chance to spend the night downtown and enjoy laughs with little travel time between activities. The club's underground feel also gives it a speak-easy, intimate vibe. | ScheduleThe Comedy Store: 916 Pearl St., La JollaDavid Letterman threw out the first joke to usher in the famed Comedy Store's La Jolla digs in 1977. The comedy spot gives visitors the comfort of a night near a scenic view of the Pacific while enjoying some laughs. | ScheduleThe Mad House Comedy Club: 502 Horton Plaza, San DiegoNational and local comics take the stage at Mad House most nights every week in Horton Plaza. | ScheduleThe Comedy Palace: 8878 Clairemont Mesa Blvd., Kearny MesaCheck out a lineup of local and nationally-featured comics taking the stage in Kearny Mesa at The Comedy Palace. | ScheduleThe Comedy Club at Pechanga: 4500 Pechanga Pkwy., TemeculaPechanga Resort Casino's Comedy Club brings together some of the comedy circuit's brightest stars and up-and-comers, offering comedy and dinner packages as well. | ScheduleSycuan Live & Up Close: 3007 Dehesa Rd., El CajonNational comedians hit the stage at Sycuan Resort & Casino's Live & Up Close performances. | ScheduleNational Comedy Theatre: 3717 India St., San DiegoImprov comedy and entertainment for all ages from national troupes can be seen at National Comedy Theatre. | ScheduleWinston's Beach Club: 1921 Bacon St., Ocean BeachOpen mic nights, comedy showcases, and roast battles are held weekly at Winston's in OB. | Schedule 2017

SAN DIEGO (KGTV) - It’s a win-win situation: a sale on airfares out of San Diego, with an ultimate destination of Hawaii. Southwest Airlines opened its flight schedule Wednesday for once-daily service out of San Diego. The flights travel to Kahului, Maui, starting Apr. 14, 2020. Flights to Honolulu begin Apr. 20, 2020, Southwest reports. Fares as low as 9 each way will be available on both routes for travel between Apr. 14 and June 4, 2020, according to the airline. The tickets must be purchased Oct. 30. "We're grateful for the steadfast loyalty of our San Diego Customers and we're adding a Southwest heading to their compass of nonstop options," said Andrew Watterson, Executive Vice President & Chief Revenue Officer for Southwest Airlines. Southwest will also offer six flights of inter-island service between the two Hawaiian airports. 861

SAN DIEGO (KGTV) - Lifeguards removed a body found floating in the ocean off Sunset Cliffs Friday morning, according to San Diego Fire-Rescue.First responders were notified about 9:30 a.m. about the remains near Point Loma Ave. Lifeguards removed the body and transported it to their headquarters, officials said.The person had been in the water “a while”, according to San Diego Police.Officers told 10News they would be handling the discovery as a death report and not sending a homicide team to investigate.The person's identity and cause of death were not immediately available. 590

SAN DIEGO (KGTV) — It’s one of the few drugs shown to help fight the novel coronavirus, and a large federal study on remdesivir just entered a new phase.Previous research sponsored by the National Institute for Allergy and Infectious Disease showed remdesivir shortened recovery time in hospitalized COVID-19 patients on average from 15 days to 11 days.Now scientists and doctors are racing to find the perfect cocktail against COVD-19 by blending remdesivir with other drugs.California-based Gilead Sciences originally developed the drug to fight Ebola, but remdesivir was never approved. Gilead Sciences has offices in Oceanside.The drug works by interrupting the virus’ ability to replicate.“Remdesivir acts by shutting down virus production,” said Dr. Peter Chin-Hong, an infectious disease expert at University of California San Francisco. “It just forces the virus to stop making virus children.”Dr. Chin-Hong is studying remdesivir as part of the NIAID research.The problem is that stopping the virus from replicating isn’t enough for some severely ill patients. They suffer from a second problem: massive inflammation from the immune system’s war with the virus.That’s why scientists are trying a cocktail approach.“You have the virus to take care of, but you also have the body's response to the virus, which is inflammation, that you also have to take care of,” said Dr. Chin-Hong.Researchers started testing the first drug cocktail in May, using an arthritis drug called baricitinib that tames inflammation.But as the data on that part of the study gets crunched, researchers began testing the second cocktail this month, a combination of remdesivir and interferon beta.“Interferon beta is something we produce naturally to fight viruses,” said Dr. Chin-Hong. He said studies have shown people who don’t produce enough interferon beta struggle to fight off the virus.Researchers selected interferon beta after two small studies showed promising results against the coronavirus.Interferon beta can both reduce inflammation and kill viruses, so doctors are hoping it will be a potent one-two punch with remdesivir.Dr. Chin-Hong said he and other researchers started administering the new cocktail this month.Some patients will receive the cocktail, some will receive a placebo, and some will get remdesivir only. This kind of clinical trial is called an adaptive trial, which the FDA started encouraging in 2004. After each phase, the winning drug or cocktail will be tested against a new challenger.Dr. Chin-Hong said the eventual cocktail may include three or more drugs, similar to HIV medication. 2617

SAN DIEGO (KGTV) - Interstate 15 Express Lane signs are being changed from white to green, with other improvements, at a cost of .5 million, the San Diego County Association of Governments said Thursday.A research effort determined that the existing signs could be difficult for drivers to read, and that information about toll rates and permission to use the lanes was unclear, according to SANDAG."There's quite a bit of confusion on the motorists part, trying to understand, can I actually get in there as a carpool or not?" said Ray Traynor, SANDAG's director of operations. "Having a system that's clear to the end users is vitally important so that the lanes operate effectively."A spokesman for Caltrans says research showed a green sign with white text was more difficult to read, with the amount of information on the sign. The I-15 Express Lanes stretch for 20 miles between SR-78 in Escondido and SR-163 in Kearny Mesa. There are more than 16 access points where drivers can move in or out of the lanes.WHAT WILL CHANGEThe upgraded signs were designed to address the concerns from I-15 commuters.Improvements include: 1153

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