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WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic versions increase the risk for the birth defects cleft lip and cleft palate in babies born to women who use the medication during pregnancy, the U.S. Food and Drug Administration (FDA) said Friday in a statement.Before prescribing topiramate, approved to treat certain types of seizures in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus if a woman becomes pregnant while using the drug, the FDA said.Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines."Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation and Research. "Alternative medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.The defects range from a small notch in the lip to a groove that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.

WASHINGTON, April 4 (Xinhua) -- New research from the University of Pennsylvania School of Medicine has revealed an increased incidence of major adverse cardiac events (MACE), such as heart attack, stroke, and cardiovascular death, in patients with severe psoriasis. The study results were reported Monday at the annual American College of Cardiology meeting in New Orleans.Psoriasis is a common inflammatory skin disease, and if severe, has been demonstrated to be a risk factor for cardiovascular disease. However, the degree to which psoriasis is associated with MACE has not been defined.In a cohort study analyzing data from a general practice research database, Lead author Nehal Mehta, director of Inflammatory Risk in Penn's Preventive Cardiology program, and colleagues reviewed the case histories of over 3,600 patients with severe psoriasis and 14,300 controls. They found that patients with severe psoriasis have a 53 percent increased incidence of MACE compared to the general population. They also found that having a diagnosed case of severe psoriasis confers an additional ten-year risk of six percent on MACE.Previous work from Mehta and colleagues found that the risk of death from cardiovascular disease increased by 57 percent in patients with severe psoriasis. In addition, the relative risk of death from cardiovascular disease was even higher in younger patients, who were as young as age 40.The researchers conclude that this new estimate of increased ten-year MACE may warrant more aggressive strategies for treatment of cardiovascular risk factors in patients with psoriasis.

BEIJING, Feb. 24 (Xinhua) -- Graft remains one of the Chinese people's top concerns, as indicated by online polls from two mainstream media in China prior to the country's annual parliamentary and political advisory sessions.As of 9 p.m. on Thursday, over 54,000 Internet users voiced their concerns over "the fight against corruption and efforts to build a clean government" in an online survey launched by the Xinhua News Agency.Corruption came in at fourth place behind "curbing housing prices," "income distribution" and "control of commodity prices."The poll was launched by Xinhua and was meant to solicit public opinion ahead of the annual sessions of the National People's Congress (NPC) and the National Committee of the Chinese People's Political Consultative Conference (CPPCC).In a survey posted on People.com.cn, a website subsidiary of the People's Daily newspaper, "anti-graft" was among the most selected topics following "social security" and "judicial justice."Internet users pinned their hopes on the forthcoming parliamentary and political advisory sessions, which are scheduled to open in early March.They hope that their voices would be heard by the country's lawmakers and political advisors, who would represent them in the two sessions and would take all possible measures to tackle a number of social issues including the fight against corruption."I hope that the Central Committee of the Communist Party of China (CPC) combats graft comprehensively and severely to ensure a Party with a clean work style, a society with justice and assures the Chinese people that they would not be wronged," said an Internet user from Jiangxi province in a forum entitled "voicing my wishes to Premier Wen Jiabao at the 2011 two sessions " on xinhuanet.com.Internet users believe that the spread of corruption in some places had hindered China's economic development, undermined social stability and harmed the relationship between the people and officials.The fight against corruption, therefore, is a significant factor in determining whether or not China can reach its goals outlined in its Twelfth Five-year Program (2011-2015) on National Economic and Social Development, an Internet user wrote."Corruption has affected Chinese people's life through its spread into many social sectors. As the two sessions represent an open platform to reflect the people's will, citizens hope to push forward the cause of anti-corruption through legislation, thus addressing their common concerns." said Ren Jianmin, director of the Anti-corruption and Governance Research Center of Tsinghua University.The CPC has never relaxed its efforts to fight against corruption, experts say.Last year saw four ministerial-level Chinese officials placed under a graft probe or removed from their posts. Among these officials were Zhang Jiameng, former vice chairman of the Zhejiang Provincial People's Congress Standing Committee in southeast China, and Zhang Jingli, former deputy director of the State Food and Drug Administration.Another 11 ministerial-level officials were sentenced to life imprisonment or other severe punishments in 2010.On February 12 this year, Liu Zhijun, the Chinese Minister of Railways, was removed from his post as the Party chief of the ministry over an alleged "severe violation of discipline," becoming the latest senior official to be investigated in the country's battle against corruption.Experts believe that the downfall of high-ranking officials over corruption charges have clearly shown the determination of the CPC to enforce the Party's discipline, combat corruption and promote a clean work style.On January 10 this year, Chinese president Hu Jintao called for efforts to tackle prominent problems that have seriously harmed people's interests and sparked most public complaints during a plenary session of the CPC Central Commission for Discipline Inspection (CCDI), the Party's anti-graft body.He also pledged to combat graft and punish corrupt officials severely to win the trust of the people.Further, the CPC's drive to erase corruption yielded significant results last year.A total of 5,098 leaders at the county level or above have been punished and 804 officials were referred for prosecution last year, said Gan Yisheng, the deputy secretary of the CCDI, on January 6 this year.Despite the achievements accomplished by the CPC in its fight against corruption, Ren Jianmin believes that the anti-graft situation in China is grave and the task remain arduous.Problems concerning land acquisition and compensation, housing, food and drug safety, environmental protection, work place safety and equal access to education have been reported by the public.To handle these issues, CCDI secretary He Guoqiang urged officials on January 12 to "put people first" and "exercise the state's power for the people" when addressing problems that the public complains about.He, also a member of the Standing Committee of the CPC Central Committee Political Bureau, said that efforts should be enhanced to fight graft in fields that are most vulnerable to corruption and unhealthy practices."The two sessions have a special role to play in China's fight against corruption," said Li Chengyan, a professor at the School of Government in Peking University."Every year, the Party and the government will take effective measures after the two sessions, as a response to social concerns. The people and the media's focus on anti-graft work will push the government to solve relevant problems," he said.According to experts, however, what's more important is to put in place a sound system concerning anti-corruption, promote reform and ensure the implementation of existing measures.

TOKYO, May 21 (Xinhua) -- Japanese Economy, Trade and Industry Minister Banri Kaieda met with visiting Chinese Commerce Minister Chen Deming in Tokyo Saturday and agreed the two countries will promote bilateral trade to assist Japan's recovery after the March 11 quake and tsunami.Chen, who accompanied Chinese Premier Wen Jiabao to Japan, told Kaieda that China will offer "as much cooperation as possible to help Japan's reconstruction" by providing necessary supplies.Kaieda said Japan will strive to restore production and supply chain disrupted by the disasters as soon as possible.The two sides said they will conduct various investment and trade activities to strengthen cooperation and personnel exchange, and facilitate the smooth flow of bilateral trade so as to promote sustainable development.The two ministers signed a document on expanding bilateral economic and trade cooperation. They also reaffirmed that free and open trade will help Japan's reconstruction efforts.

BEIJING, Feb. 12 (Xinhua) -- Sales revenue of Beijing's auto market in 2011 might shrink by 60 billion yuan (about 9.1 billion U.S. dollars) due to the city limiting the number of cars purchased each month, a commerce official said Saturday.Car sales revenue will drop to 100 billion yuan in 2011 from last year's 160 billion yuan, Wang Shuxia, chief for marketing section with the Beijing Municipal Commission of Commerce, told a working meeting of the commission.A control on car purchases introduced this year limits new car license plates to 240,000 in 2011, said Wang.In 2010, more than 800,000 new cars drove onto Beijing's roads, worsening the chronic gridlock in this Chinese national capital of nearly 5 million automobiles.Wang estimated that Beijing's car sales this year will hit 580,000 units, as some cars will be sold to buyers outside of Beijing while others will be purchased by buyers who are replacing older cars.Car owners who replace their old vehicles can obtain car license plates directly without taking part in the lottery that allots 20,000 new plates each month.