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LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.

WASHINGTON, June 20 (Xinhua) -- The U.S. Food and Drug Administration (FDA) on Monday unveiled in a report a new strategy to meet the challenges posed by rapidly rising imports of FDA- regulated products and a complex global supply chain.The report, titled "Pathway to Global Product Safety and Quality," calls on the agency to transform the way it conducts business and to act globally in order to promote and protect the health of U.S. consumers.According to the report, the FDA will partner with its counterparts worldwide to create global coalitions of regulators focused on ensuring and improving global product safety and quality. The coalitions of regulators will develop international data information systems and networks, and increase the regular and proactive sharing of data and regulatory resources across world markets.The FDA will build in additional information gathering and analysis capabilities with an increased focus on risk analytics and information technology. It increasingly will leverage the efforts of public and private third parties and industry and allocate FDA resources based on risk."FDA regulated imports have quadrupled since 2000. The FDA and our global regulatory partners recognize this new reality and realize we must work proactively and collaboratively to address the challenges we face," FDA Commissioner Margaret Hamburg said in a statement. "The FDA must further collaborate and leverage in order to close the gap between our import levels and our regulatory resources. This report is an important step in ensuring we are able to fulfill our critical public health mission."

WASHINGTON, Sept. 13 (Xinhua) -- The U.S. Department of Health and Human Services (HHS), with several partners, on Tuesday launched Million Hearts, an initiative that aims to prevent one million heart attacks and strokes over the next five years.The program will focus on helping Americans make healthy choices, such as preventing tobacco use and lowering consumption of salt and trans fats, and increasing use of treatments like aspirin and blood pressure and cholesterol-lowering medications.The HHS hopes that by 2017, 65 percent of high-risk patients will be taking aspirin and have their blood pressure and cholesterol under control. Currently, only 47 percent of high-risk patients take aspirin, and only 33 percent have their cholesterol and 46 percent their blood pressure under control.They also aim to cut smoking to 17 percent of Americans from 19 percent by 2017, and seek a 20 percent drop in sodium intake and a 50 percent drop in trans fat consumption."Heart disease causes one of every three American deaths and constitutes 17-percent of overall national health spending," said HHS Secretary Kathleen Sebelius in a statement. "By enlisting partners from across the health sector, Million Hearts will create a national focus on combating heart disease."

WASHINGTON, July 27 (Xinhua) -- The solar-powered, Jupiter- bound Juno spacecraft was secured into place on top of its rocket Wednesday in preparation for launch next month, the U.S. National Aeronautics and Space Administration (NASA) announced.The launch period for Juno opens Aug. 5 and extends through Aug. 26. For an Aug. 5 liftoff, the launch window opens at 11:34 a.m. EDT (1534 GMT) and remains open through 12:43 EDT (1643 GMT).Juno will arrive at Jupiter in July 2016 and orbit its poles 33 times to learn more about the gas giant's interior, atmosphere and aurora."We're about to start our journey to Jupiter to unlock the secrets of the early solar system," said Scott Bolton, the mission 's principal investigator from the Southwest Research Institute in San Antonio. "After eight years of development, the spacecraft is ready for its important mission."

LOS ANGELES, June 23 (Xinhua) -- The sun and its inner planets may have formed differently than previously thought, NASA's Jet Propulsion Laboratory (JPL) said on Thursday.Data revealed differences between the sun and planets in oxygen and nitrogen, which are two of the most abundant elements in our solar system, said JPL in Pasadena, Los Angeles.Although the difference is slight, the implications could help determine how our solar system evolved, JPL said.NASA researchers drew the conclusion after analyzing samples returned by NASA's 2004 Genesis mission, according to JPL.The air on Earth contains three different kinds of oxygen atoms which are differentiated by the number of neutrons they contain. Nearly 100 percent of oxygen atoms in the solar system are composed of O-16, but there are also tiny amounts of more exotic oxygen isotopes called O-17 and O-18. Researchers studying the oxygen of Genesis samples found that the percentage of O-16 in the sun is slightly higher than on Earth or on other terrestrial planets. The other isotopes' percentages were slightly lower."We found that Earth, the moon, as well as Martian and other meteorites which are samples of asteroids, have a lower concentration of the O-16 than does the sun," said Kevin McKeegan, a Genesis co-investigator from University of California, Los Angeles (UCLA) and the lead author of one of two papers published this week in Science journal. "The implication is that we did not form out of the same solar nebula materials that created the sun -- just how and why remains to be discovered." Another paper detailed differences between the sun and planets in the element nitrogen. Like oxygen, nitrogen has one isotope, N- 14, that makes up nearly 100 percent of the atoms in the solar system, but there is also a tiny amount of N-15. Researchers studying the same samples saw that when compared to Earth's atmosphere, nitrogen in the sun and Jupiter has slightly more N-14, but 40 percent less N-15. Both the sun and Jupiter appear to have the same nitrogen composition. As is the case for oxygen, Earth and the rest of the inner solar system are very different in nitrogen."These findings show that all solar system objects including the terrestrial planets, meteorites and comets are anomalous compared to the initial composition of the nebula from which the solar system formed," said Bernard Marty, a Genesis co- investigator from Petrographic and Geochemical Research Center in Fracne and the lead author of the other new Science paper. " Understanding the cause of such a heterogeneity will impact our view on the formation of the solar system."Data were obtained from analysis of samples Genesis collected from the solar wind, or material ejected from the outer portion of the sun. This material can be thought of as a fossil of our nebula because the preponderance of scientific evidence suggests that the outer layer of our sun has not changed measurably for billions of years."The sun houses more than 99 percent of the material currently in our solar system, so it's a good idea to get to know it better, " said Genesis Principal Investigator Don Burnett of the California Institute of Technology, Pasadena, California. "While it was more challenging than expected, we have answered some important questions, and like all successful missions, generated plenty more."Genesis was launched in August 2000. The spacecraft traveled to Earth's L1 Lagrange Point about one million miles from Earth, where it remained for 886 days between 2001 and 2004, passively collecting solar-wind samples.JPL managed the Genesis mission for NASA's Science Mission Directorate, Washington. The Genesis mission was part of the Discovery Program managed at NASA's Marshall Space Flight Center in Huntsville, Alasca.