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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."
WASHINGTON, Jan. 16 (Xinhua) -- A new study examining weather patterns around the worldwide pandemics of influenza, which caused widespread death and illness in 1918, 1957, 1968 and 2009, finds that each of them was preceded by La Nina conditions in the equatorial Pacific. The study findings are published online Monday in the Proceedings of the National Academy of Science.The study's authors -- Jeffrey Shaman of Columbia University's Mailman School of Public Health and Marc Lipsitch of the Harvard School of Public Health -- note that the La Nina pattern is known to alter the migratory patterns of birds, which are thought to be a primary reservoir of human influenza. The scientists theorize that altered migration patterns promote the development of dangerous new strains of influenza.To examine the relationship between weather patterns and influenza pandemics, the researchers studied records of ocean temperatures in the equatorial Pacific in the fall and winter before the four most recent flu pandemics emerged. They found that all four pandemics were preceded by below-normal sea surface temperatures -- consistent with the La Nina phase of the El Nino- Southern Oscillation.The authors cite other research showing that the La Nina pattern alters the migration, stopover time, fitness and interspecies mixing of migratory birds. These conditions could favor the kind of gene swapping or genetic reassortment that creates novel and therefore potentially more variations of the influenza virus."We know that pandemics arise from dramatic changes in the influenza genome. Our hypothesis is that La Nina sets the stage for these changes by reshuffling the mixing patterns of migratory birds, which are a major reservoir for influenza," says Shaman.Changes in migration not only alter the pattern of contact among bird species, they could also change the ways that birds come into contact with domestic animals like pigs. Gene-swapping between avian and pig influenza viruses was a factor in the 2009 swine flu pandemic.

BEIJING, Oct. 10 (Xinhua) -- The State Council, or China's cabinet, announced on Monday it will tax all resource products starting Nov. 1, extending the resource tax on domestic sales of crude oil and natural gas from some regions to the entire country.The list of taxable resources widened from crude oil and natural gas to coal, rare earth, salt and metal from Nov. 1, according to the country's revised resource tax regulations.The expansion of the resource tax is part of China's efforts to encourage energy conservancy and limit environmental damage.Sales of crude oil and natural gas nationwide will be taxed at a rate between five and 10 percent of their sales value, according to the revised regulations.The regulations impose a sales tax ranging from eight (1.25 U.S. dollars) to 20 yuan per metric ton on coking coal and from 0.40 to 60 yuan per metric ton on rare earth ore.Taxes on other types of coal stood unchanged at 0.30 to five yuan per metric ton.The tax rate for other non-ferrous metals is set between 0.4 to 30 yuan per metric ton. Ferrous metals will be taxed at two to 30 yuan per metric ton.Taxes on precious non-metallic ore will be between 0.5 to 20 yuan per kg or per carat, while taxes on cheap non-metallic ore are set between 0.5to 20 yuan per metric or per cubic meter.China's current resource tax is levied based on production volume instead of sales value, thus preventing the government from benefiting from energy and commodity price increases.Nonetheless, energy giants and mining companies such as PetroChina and Sinopec have enjoyed large profit margins on the sale of resources under the current tax scheme.A resource tax on oil and natural gas was introduced at a rate of five percent in northwest China's Xinjiang Uygur Autonomous Region on June 1, 2010 before being extended to 11 other provinces in December last year.
SUVA, Oct. 3 (Xinhua) -- It is Pinktober again and Fiji like the rest of the world will be raising awareness of breast cancer too, Fiji Cancer Society Chairperson and breast cancer awareness month President Nirmala Nambiar has said."Join the fight against breast cancer through early detection and awareness." This is the message the Fiji Cancer Society is sending out this October, which is breast cancer awareness month, worldwide.Fiji Cancer Society Chairperson and breast cancer awareness month President Nirmala Nambiar said, "Fiji continues to have a high incidence of breast cancer deaths with large number of tumors presented to health professionals at a late stage due to the stigma of having the disease."In the first quarter of 2011, there were 46 new breast cancer cases recorded, whilst there were 33 new cases in the same period last year."The figures could be scary but one must understand that as the awareness increases in our communities the number of cases recorded increases," she warned.Men and women should be aware that age, obesity and family history are all factors that contribute to the risk of developing the disease.This October the Fiji Cancer Society has planned a number of events all targeted to raise awareness since the lack of information and education is dangerous.Nambiar said through partnership with the Ministry of Health, Oxfam Clinic in Suva and the Fiji Nurses Association, supported by the sponsorship of Colgate Palmolive, the focus this year is on reaching out to the rural community and making a difference to the lives of the poor and unprivileged."We have free checkups planned for the month at the major villages from Vunidawa, Korovou and Valelevu to Lami at the other end and hope that we will be able to support the women in this area who may not be able to have a check- up otherwise.According to the official, the society's western branch continues to arrange free check- ups with the support of the Patan Clinic.The awareness and free checkups have also been arranged for corporate organizations at their request and if we are not able to provide all this during October we will continue to schedule them for the following month.The Society's thanks go to Suva Private Hospital for offering half price mammograms for the month of October, Nambiar said, adding a common issue with Fiji women, according to doctors at the hospital, was the return rate."Once they hear the news that they have cancer, many women don' t return because of the fear of what's next. Hence the Society is working with the hospitals and helping counsel patients to get them back for treatment rather than fight the losing battle, since 70 percent of cancer cases can be saved through early detection and treatment," she said.The Fiji Cancer Society strongly believes that the success of the awareness program this month will set the platform for the society's ongoing initiative to drive and raise the community's understanding, get them involved and make them take care of each other.
BEIJING, Dec. 7 (Xinhua) -- China backs European efforts for further integration and supports current initiatives by the European Union to tackle the debt crisis, Chinese Foreign Ministry spokesman Hong Lei said Wednesday.Hong told a regular press briefing that China will work with the international community to help stabilize the global financial market and promote the recovery and growth of the world economy."We have noted that the EU has made a series of important proposals to address the European sovereign debt crisis and we hope such proposals can work to help stabilize the market, restore market faith and prevent the crisis from deteriorating," Hong added.Europe's powerhouses France and Germany agreed Monday on a series of reforms aimed at changing the European Union treaty to impose tough controls on eurozone budgets.The new treaty would include automatic sanctions for states that fail to observe the 3 percent deficit rule, as well as a budget-balancing rule across the eurozone.New and significant decisions to tackle the crisis might be made during the EU summit to be held from Dec. 8 to 9, Hong predicted.Leaders from the 27 member states of the European Union will meet in Brussels on Dec. 8-9 to discuss how to resolve the eurozone crisis.
来源:资阳报