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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

JIUQUAN/BEIJING, Nov. 1 (Xinhua) -- Commander-in-chief of China's manned space program Chang Wanquan announced early Tuesday that the launch of Shenzhou-8 unmanned spacecraft was successful.The spacecraft was sent into the designated orbit after the blastoff at 5:58 a.m. from the Jiuquan Satellite Launch Center in northwest Gobi desert, carried by an upgraded Long March-2F rocket.It is heading for rendezvous with Tiangong-1, or "the Heavenly Palace" that was put into space on Sept. 29 for the country's first space docking.The move, if successful, will pave the way for China to operate a permanent space station around 2020 and make the nation the world's third to do so.The combined photo taken on Nov. 1, 2011 shows the blast-off of a modified model of the Long March CZ-2F rocket carrying the unmanned spacecraft Shenzhou-8 at the Jiuquan Satellite Launch Center in northwest China's Gansu Province. Commander-in-chief of China's manned space program Chang Wanquan announced that the launch of the spacecraft was successful.Chinese Vice Premier Zhang Dejiang viewed the launch at the Jiuquan center. The launch was also observed on site by senior officials from the European Space Agency and the German Aerospace Center.The docking is scheduled to occur within two days after the launch of Shenzhou-8 and at a height of 343 km above the Earth's surface. It will return to the Earth after two docking tryouts.Chinese and German scientists will conduct 17 life science space experiments on the Chinese spacecraft Shenzhou-8, Wu Ping, spokeswoman for China's manned space program, said Monday.To ensure the success of the mission, Chinese space engineers have made "considerable modifications" on Shenzhou-8 to previous versions of the spacecraft.Shenzhou-8, with a length of nine meters and a maximum diameter of 2.8 meters, has a liftoff weight of 8.082 tonnes."More than half of the 600 or so sets of equipment have been modified, while newly designed devices account for about 15 percent of the total," Wu said.The modifications were mainly aimed at arming the spacecraft with automatic and manual rendezvous and docking capacities, and enhancing the vehicle's performance, safety and reliability, Wu said."After the improvements, the spacecraft will be able to connect with the target spacecraft Tiangong-1 for 180 days," Wu said.The unmanned spacecraft is also equipped with devices for recording real images and mechanical parameters during its flight, to test the space docking before a manned attempt.Once China has mastered the technologies of rendezvous and docking, it will be equipped with the basic technologies and capacity required for building a space station, said Zhou Jianping, chief designer of China's manned space program.Tuesday's mission will be followed by launches of spaceships Shenzhou-9 and -10 in 2012, which are also expected to dock with Tiangong-1. "At least one mission of the two will be manned," Wu said.The crew members, including probably two female astronauts, have already been selected for the possible manual space docking mission in 2012 and are being trained for manual docking skills.The space docking tests and experiments will provide crucial experience of China's construction of a 60-tonne permanent manned space station around 2020 when Chinese astronauts are expected to operate more research projects in space."It will make it possible for China to carry out space exploration of a larger scale," Zhou said.

SAN FRANCISCO, Nov. 11 (Xinhua) -- Apple on Friday said it will "continue to investigate" the unexpected iPhone battery drain as some users still see the problems after downloading a latest software update designed to address the issues."The recent iOS software update addressed many of the battery issues that some customers experienced on their iOS 5 devices. We continue to investigate a few remaining issues," said Apple in a statement made to technology news site AllThingsD.Apple released iOS 5.0.1, an update to its latest mobile operating system iOS 5 on Thursday. The update includes fixes for some bugs which are blamed for shortening the battery life of iPhones and other devices that use the system.Some users said the battery life of their iPhones look much better after the update. But according to some posts on Apple's official support forums, some iPhone owners still claimed the issue is persisting, saying they saw no difference at all after downloading the update.Complaints about the battery life of Apple's latest iPhone 4S smartphone have been piling up on the Internet in the past weeks.On Apple's official support forums, some iPhone 4S owners said their handsets' battery drained more than 10 percent every hour, even when in standby mode with some advanced features like Siri and location services completely deactivated.It is reported that Apple engineers contacted some iPhone 4S owners in Britain and installed a diagnosis file on their devices to send details back to the company's headquarters in Cupertino, California.Apple confirmed the iPhone battery issue last Wednesday, saying that a few bugs in the iOS system have caused the problem and it will release a software update in a few weeks.

SAN FRANCISCO, Oct. 27 (Xinhua) -- Hewlett-Packard(HP) on Thursday announced that it will keep its personal systems group ( PSG) and continue to sell personal computers."HP objectively evaluated the strategic, financial and operational impact of spinning off PSG. It's clear after our analysis that keeping PSG within HP is right for customers and partners, right for shareholders, and right for employees," Meg Whitman, HP president and chief executive officer, said in a statement.On Aug. 18, former CEO Leo Apotheker said HP was considering spin off the PC business, which drove shares of the company to plunge 20 percent the following day.HP then said its board of directors has authorized the exploration of strategic alternatives for the PSG, and it will consider a broad range of options that may include a full or partial separation of the PC business through a spin-off or other transaction.According to HP, the review so far revealed the depth of the integration of its PC division that has occurred across the company's key operations including supply chain and procurement.In addition, it indicated that the division has made significant contributions to HP's solutions portfolio and overall brand value."Finally, it also showed that the cost to recreate these in a standalone company outweighed any benefits of separation," HP said in a press release announcing the latest decision.HP is now the world's largest PC-maker with revenues of the PC division totaling 40.7 billion U.S. dollars for fiscal year 2010, according to figures from the company.A recent report from market research firm Gartner found that in the third quarter of 2011, HP's PC shipments grew 5.3 percent year- on-year, faster than the industry average of 3.2 percent, and its share in global PC market actually increased slightly to 17.7 percent.Though the PC division has a lower margin, the position and scale as the world's No. 1 PC-vendor gives HP advantage to negotiate with other suppliers and helps its other businesses, analysts said.The announcement to keep the PC unit is seen as the first major move of HP under new CEO Whitman, who took the job just over a month ago after replacing Apotheker on Sept. 22.

BEIJING, Jan. 10 (Xinhua) -- China's energy chief said here Tuesday that the country is under greater pressure to ensure energy supply this year as both demand and international competition for resources grows.Liu Tienan, head of the National Energy Administration (NEA), made the remarks when speaking at a national energy work conference."It is always worrisome to have to sustain supply of energy and resources for a country with 1.3 billion people," Liu said.As China is facing a "grim situation" in energy saving and emission reduction, Liu noted, it is urgent to restructure the country's energy use and control the gross consumption volume this year.To ensure a stable energy supply, China will optimize the layout of energy exploration, start construction of energy-transmission projects and other major energy programs while boosting reserves of oil, natural gas and coal in 2012, Liu said.The NEA plans to add another 200 metric tons to the country's coal-producing capacity this year plus 70 million kw of new installed power-generating capacity.If the ecology is protected and people are relocated, China will start construction of hydropower projects of 20 million kw in 2012, according to the NEA.Once safety is ensured, nuclear power will be developed after the country's new safety plan is approved.As for renewable energy development, the NEA plans to launch wind power projects with a total capacity between 15 million kw and 18 million kw, while developing 3 million kw of solar power over the new five-year period ending 2015.Liu said, in 2012, the country aims to provide electricity to another 600,000 people who currently have no access to it and expand electricity access to 5 million people by 2015.The NEA has budgeted 65 billion yuan (10.3 billion U.S. dollars) for upgrading the grids in rural areas.Over the next four years, China will facilitate the development of non-conventional natural gas, such as shale gas and coalbed methane by increasing the number of natural gas users by 100 million to 250 million.A key indicator measuring the economic vitality, power consumption rose 11.7 percent year-on-year to 4.7 trillion kWh in China in 2011. The growth in 2012 is expected to slow to 8.5 percent amid the country's economic slowdown.

来源：资阳报