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Gunfire erupted at a Connecticut nightclub early Sunday morning, killing a man and wounding four other people, police said.A 28-year-old man died in the shooting at the Majestic Lounge in Hartford’s South End, police Lt. Paul Cicero said. Two other males and two females were wounded, with two of them in surgery Sunday morning and two in stable condition, he said. None of their names were released.Police officers had been stationed outside the club because of previous problems there and reported the shooting at about 1:30 a.m. Officers rushed in, but were confronted with a large number of people running toward the exits, Cicero said.“Everybody started pushing their way out to get away from the gunfire,” he said. “It was kind of pandemonium.”Officers, however, were able to provide immediate medical care to the victims, he said.There were no suspects in custody. Officials said there was little information to release because the investigation was in the very early stages.A message seeking comment was left Sunday at a phone number for the club.Mayor Luke Bronin said Sunday that illegal handguns were involved in the shooting. He said there have been problems at the nightclub in the past, but nothing in recent weeks.City officials will be assessing what steps they can take to prevent violence at the club in the future, Bronin said.“Hartford Police Officers who were at the club responded immediately, running in the direction of gunfire, and their heroic efforts may have prevented further loss of life,” Bronin said in a statement.Streets around the club were closed for hours during the emergency response and investigation. Officials left the scene around 7 a.m.“We’re not going to have anything for quite a bit of time,′ Cicero said, responding to a question about when more information will be released. ”This is a very complex investigation.” 1875

First came a high fever, drenching sweats and muscle aches. Then, almost a month later, a weird numbness that spread down the right side of her body.Darlene Gildersleeve thought she had recovered from COVID-19. Doctors said she just needed rest. And for several days, no one suspected her worsening symptoms were related — until a May 4 video call, when her physician heard her slurred speech and consulted a specialist.“You’ve had two strokes,” a neurologist told her at the hospital. The Hopkinton, New Hampshire, mother of three is only 43.Blood clots that can cause strokes, heart attacks and dangerous blockages in the legs and lungs are increasingly being found in COVID-19 patients, including some children. Even tiny clots that can damage tissue throughout the body have been seen in hospitalized patients and in autopsies, confounding doctors’ understanding of what was once considered mainly a respiratory infection.“I have to be humble and say I don’t know what’s going on there, but boy we need to find that out because unless you know what the pathogenic (disease-causing) mechanism is, it’s going to be tough to do intervention,” Dr. Anthony Fauci, the nation’s top infectious disease expert, remarked during a medical journal interview last month.Doctors and scientists at dozens of hospitals and universities around the globe are seeking answers while trying to measure virus patients’ risks for clots and testing drugs to treat or prevent them.Gildersleeve said health authorities “need to put out an urgent warning about strokes” and coronavirus. Not knowing the possible link “made me doubt myself” when symptoms appeared, she said.Some conditions that make some COVID-19 patients vulnerable to severe complications, including obesity and diabetes, can increase clot risks. But many authorities believe how the virus attacks and the way the body responds both play a role.“COVID-19 is the most thrombotic (clot-producing) disease we’ve ever seen in our lifetime,” said Dr. Alex Spyropoulos, a clot specialist and professor at Feinstein Institutes for Medical Research in Manhasset, New York.Clotting has been seen in other coronavirus infections, including SARS, but on a much smaller scale, he said.Scientists believe the coronavirus enters the body through enzyme-receptors found throughout the body, including in cells lining the inside of blood vessels. Some theorize that it may promote clotting by somehow injuring those vessels as it spreads. That injury may cause a severe immune response as the body tries to fight the infection, resulting in inflammation that may also damage vessels and promote clotting, said Dr. Valentin Fuster, director of Mount Sinai Heart hospital in New York.It’s unclear how many COVID-19 patients develop clots. Studies from China, Europe and the United States suggest rates ranging from 3% to 70% of hospitalized COVID-19 patients; more rigorous research is needed to determine the true prevalence, the National Institutes of Health says.Prevalence in patients with mild disease is unknown and the agency says there isn’t enough evidence to recommend routine clot screening for all virus patients without clotting symptoms, which may include swelling, pain or reddish discoloring in an arm or leg.Some hospitals have found 40% of deaths in COVID-19 patients are from blood clots. Spyropoulos said that’s been true at his 23-hospital system in the New York City area, Northwell Health, which has treated over 11,000 COVID-19 patients.Cases there have dropped by almost half in the past month, allowing more time for research before an expected second and maybe third wave of infections, he said, adding: “We’re racing against time to answer the key clinical questions.”Patients hospitalized with any severe illness face increased risks for clots, partly from being bedridden and inactive. They commonly receive blood-thinning drugs for prevention. Some doctors are trying higher-than-usual doses for prevention in hospitalized coronavirus patients.A few have used powerful clot-busting medicines typically used to treat strokes, with mixed results. In guidance issued May 12, the NIH said more research is needed to show whether that approach has any benefits.Fuster was involved in preliminary research on nearly 2,800 COVID-19 patients at five hospitals in the Mount Sinai system. A look at their outcomes suggests slightly better survival chances for virus patients on ventilators who received blood thinners than among those who didn’t. Although the results are not conclusive, all COVID-19 patients at Mount Sinai receive blood thinners for clot prevention unless they are at risk for bleeding, a potential side effect, Fuster said.Some COVID-19 patients, like Gildersleeve, develop dangerous clots when their infections seem to have subsided, Spyropoulos said. Patients treated at Northwell for severe disease are sent home with a once-a-day blood thinner and a soon to be published study will detail their experiences. Spyropoulos has been a paid consultant to Janssen Pharmaceuticals, makers of Xarelto, the drug’s brand name.In addition, Northwell is taking part in a multi-center study that will test using blood thinners for clot prevention in COVID-19 patients not sick enough to require hospitalization.In a small study published May 15, University of Colorado doctors found that combined scores on two tests measuring clotting markers in the blood can help determine which patients will develop large dangerous clots. One test measures a protein fragment called D-dimer, a remnant of dissolved clots. High levels sometimes indicate dangerous clots that form deep in leg veins and travel to the lungs or other organs.Dr. Behnood Bikdeli of Columbia University’s Irving Medical Center, said D-dimer levels in many of his COVID-19 patients have been alarmingly high, as much as 50 times higher than normal.Concerns about blood clots in COVID-19 patients prompted a recent 30-page consensus statement from an international group of physicians and researchers. Bikdeli is the lead author.It says that testing to find clots that require treatment includes X-rays or ultrasound exams, but poses a risk for health care workers because the virus is so contagious. Bikdeli said he fears when protective gear was more scarce, some dangerous clots were undiagnosed and untreated.Social distancing may make people more sedentary and more vulnerable to clots, particularly older adults, so doctors should encourage activity or exercises that can be done in the home as a preventive measure, the statement says.Warnell Vega got that advice after collapsing at home April 19 from a large clot blocking a lung artery. Doctors at Mount Sinai Morningside think it was coronavirus-related. Vega, 33, a lunch maker for New York City school children, spent a week in intensive care on oxygen and blood thinners, which he’s been told to continue taking for three months.“I just have to watch out for any bleeding, and have to be careful not to cut myself,” Vega said.Gildersleeve, the New Hampshire stroke patient, was also sent home with a blood thinner. She gets physical therapy to improve strength and balance. She still has some numbness and vision problems that mean driving is out, for now.Doctors are unable to predict when or whether she’ll regain all her abilities.”I’m trying to remain positive about recovering,” she said. ’’I just have to be patient and listen to my body and not push too hard.”___Follow AP Medical Writer Lindsey Tanner at @LindseyTanner.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’ 7639

Fear of the coronavirus has led people to stock up on hand sanitizer, leaving store shelves empty and online retailers with sky-high prices set by those trying to profit on the rush. But more of the clear gel is on the way. Purell, the best-selling hand sanitizer, is pumping up production. Walmart and other stores say they are talking to suppliers to stock up bare shelves. Sales of hand sanitizers in the U.S. were up 73 percent in the four weeks ending Feb. 22, compared with the same period the year before, according to market research firm Nielsen. 568

Fred "Curly" Neal, a Harlem Globetrotters icon who played in more than 6,000 games, has died, the team announced Thursday. He was 77. Neal played in 97 countries. On Feb. 15, 2008, Curly became just the fifth Globetrotter to have his jersey number retired, according to the team."Between 1963 and 1985 - before the internet and cable television really existed-it was Curly Neal and the Harlem Globetrotters who first introduced the sport of basketball to millions of people around the world for the first time," the Globetrotters tweeted. "It was Curly's magical ball-handling, shooting, charismatic smile and iconic bald head, in more than 6,000 games in 97 countries, that made them start to play and fall in love with the game."Globetrotters General Manager Jeff Munn called Neal "one of the most genuine human beings the world has ever known."“Curly’s basketball skill was unrivaled by most," Munn said. "His warm heart and huge smile brought joy to families worldwide.”Former player Curley Boo Johnson mourned Neal's death. "The world lost a true ambassador of the game of basketball and outside of Muhammad Ali one of the most recognizable faces on the Planet! Rest In Peace my Brother," he tweeted.This story was published by Aliza Chasan at WPIX. 1266

FORT STEWART, Ga. – Three soldiers were killed Sunday morning when the vehicle they were riding in was involved in a training accident at the Fort Stewart-Hunter Army Airfield. The three 1st Armored Brigade Combat Team soldiers were pronounced dead at the scene and three other soldiers were transported to Winn Army Community Hospital to be treated and evaluated for their injuries, according to the Georgia airfield. The US Army on Monday identified the three soldiers killed during a training accident.The three deceased soldiers are Sgt. 1st Class Bryan Jenkins, 41, of Gainesville, Florida, Cpl. Thomas Walker, 22, of Ohio, and Pfc. Antonio Garcia, 21, of Arizona. All three were part of the 3rd Infantry Division's 1st Armored Brigade Combat Team. Officials say the soldiers were riding in a Bradley Fighting Vehicle when the accident happened. “Today is a heartbreaking day for the 3rd Infantry Division, and the entire Fort Stewart-Hunter Army Airfield community, as we are all devastated after a training accident this morning on the Fort Stewart Training Area,” said Maj. Gen. Tony Aguto, commanding general of the 3rd Infantry Division. “We are extremely saddened by the loss of three Dogface Soldiers, and injuries to three more. Our hearts and prayers go out to all the families affected by this tragedy."The incident is under investigation and names of the soldiers involved in the accident are expected to be released after next-of-kin are notified. "The entire 3ID extends its deepest condolences to the families of the soldiers involved in this incident," wrote the airfield in a press release. 1623