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WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.
LOS ANGELES, Sept. 1 (Xinhua) -- Fisker Automotive, a Southern California electric car maker, announced on Thursday that it has signed a pact with BMW regarding the supply of engines and other related components for future models in a major tieup.The Anaheim, Orange County-based U.S. car maker will get a four-cylinder turbocharged engine, totalling 100,000 units every year, for its next generation of cars under a project code-named "Project Nina," the company said.The production of the model, a mass-market plug-in hybrid sedan, will begin at the end of 2012 and the sale is slated for 2013."The BMW engine was an obvious choice for us, as BMW is known for producing the best and most fuel efficient gasoline engines in the world," Fisker's CEO and Executive Design Director Henrik Fisker said. "We are very pleased to have signed this agreement with BMW."The firm did not disclose the terms.The U.S. automaker, founded in 2007, has produced electric vehicles with extended range (EVer). The first derivative of "Project Nina" will be a mid-sized premium sedan which utilizes the technology.The company's other products include Fisker Karma Sedan, a luxury sports car and the world's first premium electric plug-in hybrid.

BEIJING, Sept. 4 (Xinhua) -- China's railway system has transported some 1.27 billion passengers during the first eight months of this year, up 11.8 percent from a year earlier, the Ministry of Railways said Sunday.The figure has accounted for 67.4 percent of the ministry's full-year target, said the ministry in a statement on its website.The Ministry of Railways has planned to send 1.9 billion passengers in 2011, up 13.1 percent year-on-year.The country's high-speed trains had been operating with improved order and efficiency, said the ministry, which has been required to run high-speed trains at slower speeds, as well as to reorganize bullet train schedules nationwide, for safety reasons.The State Council, or Cabinet, ordered increased safety checks after a fatal train collision that killed 40 people in July raised concerns over the safety of the country's high-speed railways.The ministry cut the number of high-speed trains running between Beijing and Shanghai to 66 pairs from 88 pairs per day, effective as of Aug. 16.Meanwhile, the railways transported more than 2.6 billion metric tons of goods from January to August, up 7.8 percent year-on-year, the ministry said.
BEIJING, June 20 (Xinhuanet) -- American Cancer Society discloses that higher education appears to be a game changer when it comes to cancer, according to foreign media reports on Sunday. The research indicates that the gap is widening in cancer death rates between college graduates and those who only went to high school .Cancer death rates for those who didn’t finish high school are almost three times higher than those of college graduates. The gap was especially wide for lung cancer, but it was also palpably large for breast, colon, and prostate cancer. For lung cancer, the death rate was five times higher among the least educated Americans than the most educated.Ahmedin Jemal, ACS Vice President of Surveillance Research, said that higher smoking and obesity rates among lower-income Americans combined with less access to medical services mainly expounds the disparity.Researchers concluded that bridging the education-socioeconomic gap would have prevented about 60,000 premature cancer deaths in 2007 alone in people in the 25-64 age group.
LOS ANGELES, June 17 (Xinhua) -- The size of low-oxygen zones created by respiring bacteria is extremely sensitive to changes in depth caused by oscillations in climate, thus posing a distant threat to marine life, a new study suggests."The growth of low-oxygen regions is cause for concern because of the detrimental effects on marine populations -- entire ecosystems can die off when marine life cannot escape the low- oxygen water," said lead researcher Curtis Deutsch, assistant professor of atmospheric and oceanic sciences at University of California, Los Angeles."There are widespread areas of the ocean where marine life has had to flee or develop very peculiar adaptations to survive in low- oxygen conditions," Deutsch said in the study to be published in an upcoming print edition of the journal Science.A team led byDeutsch used a specialized computer simulation to demonstrate for the first time that fluctuations in climate can drastically affect the habitability of marine ecosystems.The study also showed that in addition to consuming oxygen, marine bacteria are causing the depletion of nitrogen, an essential nutrient necessary for the survival of most types of algae."We found there is a mechanism that connects climate and its effect on oxygen to the removal of nitrogen from the ocean," Deutsch said. "Our climate acts to change the total amount of nutrients in the ocean over the timescale of decades."Low-oxygen zones are created by bacteria living in the deeper layers of the ocean that consume oxygen by feeding on dead algae that settle from the surface. Just as mountain climbers might feel adverse effects at high altitudes from a lack of air, marine animals that require oxygen to breathe find it difficult or impossible to live in these oxygen-depleted environments, Deutsch said.Sea surface temperatures vary over the course of decades through a climate pattern called the Pacific Decadal Oscillation, during which small changes in depth occur for existing low-oxygen regions, Deutsch said. Low-oxygen regions that rise to warmer, shallower waters expand as bacteria become more active; regions that sink to colder, deeper waters shrink as the bacteria become more sluggish, as if placed in a refrigerator."We have shown for the first time that these low-oxygen regions are intrinsically very sensitive to small changes in climate," Deutsch said in remarks published Friday by the American Association for the Advancement of Science on its website. "That is what makes the growth and shrinkage of these low-oxygen regions so dramatic."Molecular oxygen from the atmosphere dissolves in sea water at the surface and is transported to deeper levels by ocean circulation currents, where it is consumed by bacteria, Deutsch said."The oxygen consumed by bacteria within the deeper layers of the ocean is replaced by water circulating through the ocean," he said. "The water is constantly stirring itself up, allowing the deeper parts to occasionally take a breath from the atmosphere."A lack of oxygen is not the only thing fish and other marine life must contend with, according to Deutsch. When oxygen is very low, the bacteria will begin to consume nitrogen, one of the most important nutrients that sustain marine life."Almost all algae, the very base of the food chain, use nitrogen to stay alive," Deutsch said. "As these low-oxygen regions expand and contract, the amount of nutrients available to keep the algae alive at the surface of the ocean goes up and down. "Understanding the causes of oxygen and nitrogen depletion in the ocean is important for determining the effect on fisheries and fish populations, he said.
来源:资阳报