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A final analysis of a COVID-19 vaccine candidate produced by Pfizer and BioNTech shows that the drug is 95% effective in preventing the coronavirus, and the companies say they hope to apply for Emergency Use Authorization within "days," the company reported Wednesday.The announcement is an improvement from an initial analysis released by the company just over a week ago that showed the drug to be 90% effective. Those results were released when it had been confirmed that 94 participants in the trial who received a shot had contracted COVID-19, and only 10% of those participants who contracted the virus had actually received the vaccine. Updated information now shows that 170 people who participated in the trial have contracted COVID-19, which crosses the threshold for final analysis. Of those participants, 162 received a placebo shot. Of the 20,000 participants who received the vaccine, just one has developed a severe case of COVID-19. The other seven people who received the vaccine and caught the virus are only experiencing mild symptoms.Pfizer also added that the vaccine has proven to be 94% efficient in older people — a welcome sign, given that the virus tends to present more severe symptoms in elderly patients.Pfizer's trial included about 40,000 participants, half of which received the vaccine, and the other half which received the placebo. The vaccine requires two shots, which need to be taken 28 days apart.The company added that there have been no safety concerns with the vaccine. In a randomized survey of 8,000 participants, only 2% reported suffering severe fatigue, and only 4% reported suffering severe headaches. Those who say they suffered side effects only experienced them briefly after vaccination.Wednesday's announcement means Pfizer is on track to shatter records for vaccine development, a process that typically takes several years.Pfizer and BioNTech already have their vaccine candidate in production, meaning it will be ready for distribution as soon as the Food and Drug Administration grants Emergency Use Authorization.Pfizer's announcement comes days after an initial analysis of a Moderna-produced vaccine was also shown to be 95% effective. Several other companies also have a COVID-19 vaccine in the works, something that health officials say is important for logistics and safety. 2347
A Dutch lawyer tied to former Trump deputy campaign chairman Rick Gates who admitted to lying to special counsel Robert Mueller's team was sentenced Tuesday to 30 days in prison and ordered to pay a ,000 fine.Alex van der Zwaan is the first person to be sentenced in Mueller's investigation into Russian interference in the 2016 election.He pleaded guilty to lying to Mueller's team in February and faced up to six months in prison. 443

A detailed look at COVID-19 deaths in U.S. kids and young adults released Tuesday shows they mirror patterns seen in older patients.The report examined 121 deaths of those younger than 21, as of the end of July. Like older adults, many of them had one or more medical condition — like lung problems, including asthma, obesity, heart problems or developmental conditions.Deaths were also more common among those in certain racial and ethnic groups, according to the report from the Centers for Disease Control and Prevention. The CDC found 54 were Hispanic, 35 were Black, and 17 were white, even though overall there are far more white Americans than Black and Hispanic.“It’s really pretty striking. It’s similar to what we see in adults,” and may reflect many things, including that many essential workers who have to go to work are Black and Hispanic parents, said Dr. Andrew Pavia, a pediatric infectious diseases expert at the University of Utah. He was not involved in the CDC study.The numbers of young deaths are small though. They represent about 0.08% of the total U.S. deaths reported to CDC at the time, though children and college-age adults make up 26% of the U.S. population.Fifteen of the deaths were tied to a rare condition called multisystem inflammatory syndrome, which can cause swelling and heart problems.The report also found nearly two-thirds of the deaths were in males, and that deaths increased with age. There were 71 deaths among those under 17, including a dozen infants. The remaining 50 deaths were ages 18 to 20.Scientists are still trying to understand why severe illnesses seem to become more common as children age. One theory is that young children have fewer sites on their airway surfaces that the coronavirus is able to attach to, Pavia said. Another is that children may be less prone to a dangerous overreaction by the immune system to the coronavirus, he added.Thus far this year, the COVID-19 toll in children is lower than the pediatric flu deaths reported to the CDC during a routine flu season, which has been about 130 in recent years. But comparing the two is difficult for a number of reasons, including that most schools weren’t open during the spring because of the pandemic.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2427
A gunman who killed four people in Northern California rammed a pickup through a locked gate and marched onto the grounds of an elementary school, but he could not enter the classrooms, authorities say.He fired his rifle through windows and walls, and tried the doors, but the buildings at the Rancho Tehama Reserve school were secure.Only an outside bathroom was open, but it was empty. 395
A majority of voters in Puerto Rico approved a non-binding referendum that supports elevating the island territory to statehood status.The referendum narrowly passed by a 52-48 margin.The question was not the first time voters weighed in on Puerto Rico statehood. Most recently, 97% of voters approved statehood in 2017, but the vote was boycotted by opposition parties.Several previous referenda were not a straight up statehood vote.Given Puerto Rico’s status, the territory does not vote on US senators or representatives, although the territory elects a non-voting member who can serve on committees. Puerto Rico also does not get a vote in the presidential general election, but the territory does get a say in the Democratic and Republican primaries.While Democrats would likely welcome the opportunity to make Puerto Rico a state, the likelihood of there being enough political support for Puerto Rico to be the 51st state is still doubtful. 956
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