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Immunotherapy has gained ground against a stubborn opponent: ovarian cancer. A personalized cancer vaccine is safe and may lengthen the lives of ovarian cancer patients, a small clinical trial found.The research, published Wednesday in the journal Science Translational Medicine, showed "significantly higher" overall survival at two years among patients who received the vaccine, compared with patients who did not.Ovarian cancer is a "silent killer" because often it goes unnoticed until it is diagnosed at a late stage. Treated with surgery followed by chemotherapy, most patients -- 85% -- relapse and ultimately develop resistance to the chemo. At this point, they run out of treatment options.Still, scientists are hopeful based on the fact that a subset of patients shows an immune response to their cancer. Generally, these patients have better survival rates than those whose immune systems don't react in the same way.A vaccine, then, might be able to trigger and boost the immune system and increase the survival rates of patients, said Dr. Lana Kandalaft, senior author of the new study and an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine.  1210

If we're sick, we don't think twice about seeing a doctor. Health experts say we need to start looking at obesity the same way. One woman has turned her life around. And as she's lost weight, she's gained so much more."We're grazers," Marcie Weiler recalls. "I was brought up just (hands to mouth motion) mindlessly. Totally mindlessly just pop it in."That's how Weiler grew up thinking about food. And after a few serious injuries?"My coping mechanism was soda pop and food of course," Weiler says.At her heaviest, she weighed 300 pounds."I just thought, 'Oh my God, I'm going to keep getting bigger,'" Weiler saysShe's not alone. Obesity rates in the United States are at all time high. 40 percent of all Americans are considered obese and 20 percent morbidly obese."It affects cardiovascular health," says Dr. John Weaver, a general and bariatric surgeon with Presbyterian / St. Luke's Medical Center. "It affects you know pulmonary health and diabetes it affects joint pain and problems."Dr. Weaver says the effects can be serious, and potentially deadly. A new study found improvements in mortality rates are slowing, obesity is the main cause, and many people look the other way."Only 20 to 30 percent of people who are obese had even talked to their doctor about their obesity," Dr. Weaver says. "And the problems that go along with being obese."Dr. Weaver says it is possible to be overweight and healthy, but your body mass index can let you know for sure. And once you've figured that out, beating obesity isn't just about cutting calories and working out. There's a new understanding that the biggest challenge, is revamping your lifestyle."It's an entire body change," Dr. Weaver says. "It's not just an eating habit it's changing your eating habits but it's changing how you perceive food. And everything that goes along with food."That's what Weiler has done. Along with bariatric surgery, she has lost more than 100 pounds. But that's not the only thing that's changed."My general opinion of myself," Weiler says.Reversing a trend, for a healthier and potentially longer life. 2099

If you want to feel happier, then you'll need to move to Hawaii.According to WalletHub, Hawaii is the happiest state of 2020.Source: WalletHubResearchers at WalletHub looked at environmental factors, like economic, emotional, physical, and social health, often linked to how satisfied people are with life.They then compared how much people work to people's rates of depression and unemployment.With its gorgeous beaches, the fantastic weather, and the scenic views, it's no wonder the aloha state came out on top.West Virginia was ranked the least happy state. 569

Hurricane #Eta Advisory 12A: Eyewall of Extremely Dangerous Hurricane Eta Moving Onshore Along the Coast of Northeastern Nicaragua. https://t.co/VqHn0u1vgc— National Hurricane Center (@NHC_Atlantic) November 3, 2020 223

Hunters in the Florida Everglades continue to pull out some massive pythons in an attempt to eliminate the invasive species from the Sunshine State.The South Florida Water Management District on Wednesday posted a video that showed famed python hunter Dusty Crum with one of his recent catches -- a 16-foot, 11-inch whopper!The snake broke Crum's own record for the longest snake caught as part of SFWMD's Python Elimination Program.The district said Crum captured the python late last Thursday.Since the program began in late March, hunters have removed 638 invasive pythons from the Everglades. 624