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SAN DIEGO (KGTV) - U.S. Customs and Border Protection started Tuesday construction on its second border wall project along the U.S-Mexico border. The 14-mile long project consists of crews replacing existing barriers with new 30-foot tall steel bollards. The contract was awarded to Texas-based construction company SLSCO Ltd. The secondary wall project runs just north of the primary fence replacement project which started last summer. 446

SAN DIEGO (KGTV) — UC San Diego researchers are testing a technology that's been in development for more than a decade to fight the coronavirus.In lab experiments, "nanosponges" covered in human lung cell membranes and immune cell membranes were found to attract and neutralize the SARS-CoV-2 virus in cell culture, according to a UCSD release. This caused the virus to lose about 90% of infectivity, or its ability to hijack cells and reproduce.The tiny sponges are designed to impersonate and protect healthy cells by soaking up harmful pathogens and toxins, according to Liangfang Zhang, a nanoengineering professor at the UC San Diego Jacobs School of Engineering. RELATED: San Diego company's COVID-19 test gets emergency approvalFor example, the nanoparticle covered in membranes from cell types the virus is known to invade latch on to the virus. This prevent the virus from then entering an actual human cell."Traditionally, drug developers for infectious diseases dive deep on the details of the pathogen in order to find druggable targets. Our approach is different. We only need to know what the target cells are. And then we aim to protect the targets by creating biomimetic decoys," said Zhang.While Zhang has spent the last 10 years developing the technology, his lab turned to using the nano-particle to fight the coronavirus when the pandemic hit.RELATED: Scripps Research's antibodies study shows signs of success against coronavirusNow, the first data on the technology's ability to battle the virus is being released after testing by researchers at Boston University."Another interesting aspect of our approach is that even as SARS-CoV-2 mutates, as long as the virus can still invade the cells we are mimicking, our nanosponge approach should still work. I’m not sure this can be said for some of the vaccines and therapeutics that are currently being developed," said Zhang.UCSD researchers will test the nanosponges’ effectiveness in animal models in the next few months and are moving as fast as possible to eventually test the technology in humans. RELATED: Startup creates mobile COVID-19 testing clinic on wheelsNanosponges have a massive amount of testing ahead before they make it to human tests, Zhang said."I see potential for a preventive treatment, for a therapeutic that could be given early because once the nanosponges get in the lung, they can stay in the lung for some time," Zhang said. "If a virus comes, it could be blocked if there are nanosponges waiting for it."(Read more about the study and nanosponges here.) 2562

SAN DIEGO (KGTV) - Video shows a brutal fight outside a Pacific Beach bar and restaurant that sent a bouncer to the hospital with critical injuries. The assault happened at about 9:20 p.m. at the Firehouse, 722 Grand Ave., according to San Diego Police. Four men tried to get into the restaurant through a side entrance but the main bouncer told them to use the main door, officers said. One of the men picked up a metal crowd barrier stanchion pole and struck the bouncer over the head, said police. The bouncer suffered a skull fracture and brain bleed. Officers said he is currently in critical but stable condition in the hospital. After the pole strike, the three other men in the group began fighting with security staff members. One of the bouncers suffered a broken nose and the other two had bumps and bruises, police said. The man responsible for the pole attack is described as African-American, in his 30s, 6’0” tall, 250 pounds with a muscular build. He was wearing a white t-shirt and jeans. All four men left the area. Anyone with information is asked to call San Diego Police at 619-531-2000. 1116

SAN DIEGO (KGTV) - Whether you're looking to eat, drink, or stroll around San Diego this weekend, there's an event just for you.Mission Beach will celebrate is delicious culinary scene Thursday in its annual Taste of Mission Beach event, benefiting clean beaches.Still hungry? San Diego Taco Fest heads to town Saturday for some delicious fun, live music, and Lucha Libre action in Waterfront Park.Don't see anything interesting? Check our 10News event calendar for even more local happenings!Pirates will take over the San Diego Maritime Museum for a two-day celebration of the seven seas, and cowboys and cowgirls will saddle up in Ramona for some rodeo fun:THURSDAY5th Annual Taste of Mission BeachWhere: Various restaurants; Cost: Mission Beach invites foodies to walk, ride, or sail to as many Mission Beach restaurants and sample their delicious eats during Taste of Mission Beach. Proceeds from the event benefit the Pacific Beach Street Guardians, which works to keep beach communities clean. Encinitas Cruise NightsWhere: Downtown Encinitas; Cost: FreeDowntown Encinitas will be hopping with the sounds of rock n' roll against a backdrop of muscle, hot rod, and classic cars from D St. to K St. Check out historic vehicles from local owners, enjoy live music, and stick around to see whose rides win some awards or grab some dinner on Highway 101. 1397

SAN DIEGO (KGTV) - UC San Diego researchers want to understand better how humans are impacting climate change, looking to the ocean for answers. Inside the Hydraulics Lab at the Scripps Institution of Oceanography sits a large tank mimicking the ocean. "It's a one-of-a-kind experiment that has taken us eight years to get to the point of doing," said Kimberly Prather, Professor of Atmospheric Chemistry at UC San Diego. Funding for the novel project comes from the National Science Foundation, which put million into the first five years of research and another million into the next five years. When waves break, salts and other living material including viruses and bacteria are launched in the form of sea spray aerosols into the atmosphere. Scientists are interested in better understanding the role of these particles in controlling climate by forming clouds over oceans that cover nearly three-quarters of the earth's surface.Now the research includes experiments to determine how pollution from human activities interact with natural ocean emissions and change the chemical composition of the atmosphere."A lot of people still deny that humans are the ones changing things, this experiment will pinpoint how much and how fast humans are changing things," said Prather.She says changes in the ocean, atmosphere, and climate are happening much faster than scientists once thought. "We used to say we're passionate about it because it's affecting our kids and our grandkids. But it's affecting us right now, today," said Prather.They hope to pinpoint which human activities, like car emissions or coal combustion, are doing the most harm.Prather hopes answers discovered in the lab will guide policymakers on how to tackle the growing threat. 1765