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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- At least one San Diego woman is a part of thousands who've volunteered to participate in a human challenge trial to find a vaccine for COVID-19. April Simpkins is a healthy 29-year-old. Simpkins said she felt helpless watching as the pandemic spread around the world, until she heard about 1 Day Sooner while listening to a podcast. 1 Day Sooner is an organization that advocates for volunteers willing to participate in a human challenge trial. The trial means being infected with COVID-19 in hopes of speeding up the process for a vaccine. The trial is restricted to young and healthy people. So far, there is no plan for any human challenge trials to fight COVID-19, but over 30,000 thousand people, from over 140 countries, have signed up to volunteer. The hope is to have the list of volunteers ready, if and when such a trial is approved. The trial would still require approval from a type of medical ethics board and from the Food and Drug Administration. To find out more about 1 Day Sooner click here. 1038

SAN DIEGO (KGTV) — Border Patrol agents arrested five people in connection with a human smuggling incident, including one man convicted of being a sexual predator.A vehicle traveling through a temporary immigration checkpoint in Potrero failed to stop at about 6:30 a.m. Wednesday, according to U.S. Customs and Border Protection, before agents stopped the vehicle several yards past the checkpoint.Agents say five males in the vehicle were questioned. Three passengers in the vehicle's backseat said they were from Mexico but had no U.S. documentation, according to CBP. The driver and front seat passenger claimed to be from the U.S.The driver and front passenger were arrested on suspicion of smuggling and the three other passengers were arrested for being in the U.S. illegally, CBP said. During a records check at a nearby station, agents learned one passenger, a 39-year-old Mexican national, was convicted in 2012 of kidnapping and rape of a minor in San Diego. He was sentenced to a seven-year prison term and removed from the U.S.“I am proud of the great work agents demonstrated in arresting this known child predator,” said Chief Patrol Agent Douglas Harrison. “Their actions help keep our communities safer.”Both U.S. citizens face human smuggling charges and the previously deported Mexican man faces federal charges. The two other passengers will be processed for removal from the country. 1413

SAN DIEGO (KGTV) -- Car insurance is on the rise throughout San Diego and California.According to The Zebra, the average annual auto insurance premium for San Diego is more than ,600.Still, insurance is cheaper in San Diego than other parts of California. Drivers in Los Angeles pay an average of ,928 per year for insurance. Since 2011, the San Diego metro has seen rates rise 45 percent, more than doubling the 20 percent increase nationwide.California doesn’t factor things like credit and education into car insurance rates.According to the report, rising insurance rates are likely due to a combination of severe weather and more drivers on the road.Overall, California is the ninth most expensive state for car insurance with the most expensive being Michigan and the least expensive North Carolina. 822

SAN DIEGO (KGTV) – Dance is a way to lose yourself and escape. For students taking the Ballet for Me! Class at the San Diego Civic Youth Ballet School in Balboa Park, dance is their escape.“I just love it cause it like brings me joy and it can take me to my happy place,” said Renata Scorza-Muniz.Renata has been taking regular ballet classes since she was 2 years old. But in February, her life changed.“It’s stressful, I guess, to be in the hospital,” said Renata.Renata was diagnosed with cancer, causing her to lose her vision and forcing her out of her regular ballet class.That’s when she turned to a class called Ballet for Me.“It’s just so fun to do,” said Renata.Ballet for Me is a tuition-waved class that is designed for kids with unique physical needs. Each student in the class gets paired up with a mentor to help guide them through each movement.“It just makes me so happy when I get to see students feel happy and free in class,” said Kerri DeNies instructor and creator of the class.This dance class helps the kids feel whole again. And all year they rehearse for their moment to shine and perform in front of a packed audience where they feel a little more joy and beam with confidence. 1213