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President Donald Trump’s physical Dr. Sean Conley confirmed Friday that the president is taking an experimental antibody treatment to help him fight the coronavirus following his diagnosis this morning.Dr. Conley said Friday afternoon that Trump is "fatigued."Trump is taking the Regeneron antibody cocktail, which is currently in a clinical trial. Conley said that Trump has been treated with a single 8 gram dose, which Conley said was infused "without incident."Trump is also said to be taking Vitamin D, zinc, famotidine, melatonin and daily aspirin. The Regeneron trial has only been tried on 275 patients as of this week, but the company said earlier this week that it has showed promising results.Regeneron confirmed that Trump was given the treatment under a "compassionate use request.""In the USA, this type of compassionate use program is also known as an Expanded Access Program (EAP) and is intended for patients with serious or life-threatening conditions, who do not have any viable or available treatment options, and are unable to participate in ongoing clinical trials," Regeneron said in a statement. The plan is to enroll 2,000 patients in early studies of the treatment."After months of incredibly hard work by our talented team, we are extremely gratified to see that Regeneron's antibody cocktail REGN-COV2 rapidly reduced viral load and associated symptoms in infected COVID-19 patients," said George D. Yancopoulos, M.D., Ph.D., President and Chief Scientific Officer of Regeneron. "The greatest treatment benefit was in patients who had not mounted their own effective immune response, suggesting that REGN-COV2 could provide a therapeutic substitute for the naturally-occurring immune response. These patients were less likely to clear the virus on their own, and were at greater risk for prolonged symptoms.The treatment is a combination of two monoclonal and was designed specifically to block infectivity of SARS-CoV-2, the virus that causes COVID-19, the company said.“The two potent, virus-neutralizing antibodies that form REGN-COV2 bind non-competitively to the critical receptor binding domain of the virus's spike protein, which diminishes the ability of mutant viruses to escape treatment and protects against spike variants that have arisen in the human population, as detailed in Science.” Regeneron said in a statement. “Preclinical studies have shown that REGN-COV2 reduced the amount of virus and associated damage in the lungs of non-human primates.”According to Regeneron, the treatment has been tried on hospitalized and non-hospitalized patients and as a preventative for those who have had close contact with coronavirus patients. So far, the drug has been particularly promising for non-hospitalized patients.Regeneron said the treatment reduces the viral load from the coronavirus, and boosts the body’s immune response to the virus. 2890
Republicans angry with the Justice Department over not providing documents to Congress are urging President Donald Trump to intervene in the latest dispute between House Intelligence Chairman Devin Nunes, a California Republican, and Attorney General Jeff Sessions.Nunes threatened on Fox News over the weekend to hold Sessions in contempt after the Justice Department said it would not comply with his subpoena sent last month about records tied to the Russia investigation and the Foreign Intelligence Surveillance Act.The move could give Trump a new reason to take aim at his attorney general, a frequent punching bag of the President's for recusing himself from overseeing the Russia investigation. If Sessions doesn't comply, Democrats fear it would give Trump new reason to fire his attorney general and appoint a replacement who would be in charge of special counsel Robert Mueller's investigation. 913
Raise your hand if you know someone who has moved to Atlanta, Dallas-Fort Worth or Houston recently. A lot of hands went up, because those are the three fastest-growing metropolitan areas — and they have relatively affordable home prices, too.Each quarter, NerdWallet calculates home affordability for 172 metro areas. NerdWallet narrowed its focus this quarter to the 10 metros that had the most population growth from mid-2016 to mid-2017, the latest data available from the U.S. Census Bureau. Among these 10, Atlanta had the most affordable home prices this spring and Seattle had the least affordable.The top three metros on this list have two things in common, says Danielle Hale, chief economist for Realtor.com: They have space to grow, with few physical barriers such as mountains and oceans, and they have local governments that “are more willing to permit and allow development, too.”Affordability was calculated by comparing incomes and median home prices. A place with high incomes and low home prices is more affordable than an area with low incomes and high home prices.Here are the 10 fastest-growing metro areas, ranked from most to least affordable for buying a home in the second quarter of 2018. The rankings were compiled using data from the National Association of Realtors, the U.S. Census Bureau and NerdWallet surveys.? MORE: How much home can you afford in your area? 1416
President Donald Trump's televised meeting Wednesday with lawmakers on gun control "made for great TV," a National Rifle Association spokesperson told CNN -- but the group was not entertained by the President's apparent sharp turn on policy."While today's meeting made for great TV, the gun-control proposals discussed would make for bad policy that would not keep our children safe," NRA public affairs director Jennifer Baker said. "Instead of punishing law-abiding gun owners for the acts of a deranged lunatic, our leaders should pass meaningful reforms that would actually prevent future tragedies."Lawmakers should focus on "fixing the broken mental health system, strengthening background checks to ensure the records of people who are prohibited from possessing firearms are in the (National Instant Criminal Background Check) system, securing our schools and preventing the dangerously mentally ill from accessing firearms," Baker added.During the meeting, Trump insisted that he is "a fan of the NRA," but he chided Republicans for being "afraid" of the gun lobby. Meanwhile, he expressed openness to measures that the NRA and some Republicans oppose, including raising the age limit to purchase firearms to 21 from 18. The President's remarks left Republicans visibly shell-shocked and Democrats giddy.Trump was skeptical that major gun policy changes would present a political risk, saying it would be "so easy" to harness the 60 votes needed to avert a filibuster in the Senate. And he pointedly dismissed the power of the NRA to derail the effort, telling lawmakers in the room, "They have great power over you people, they have less power over me.""Some of you people are petrified of the NRA," Trump added. "You can't be petrified." 1756
PROVIDENCE, R.I. (AP) — Eight acrobats injured when the rigging suspending them by the hair plummeted to the floor during a circus performance in Rhode Island in 2014 have reached a .5 million settlement with ownership and management of the arena where the circus was held.Zachary Mandell, an attorney for the women, confirmed the settlement, first reported by The Providence Journal.A metal clip that held the acrobats 20 feet above the floor of the Dunkin' Donuts Center snapped.The women sued the Rhode Island Convention Center Authority, which owns the arena, and SMG, which manages it.According to the Associated Press, SMG arranged with Feld Entertainment to bring the Ringling Bros. and Barnum & Bailey Circus to Providence.The Department of Labor's Occupational Safety and Health Administration (OSHA) found that the clip was overloaded after the accident, so they cited Feld and imposed a fine, the AP reported.An attorney for both entities said he could neither confirm nor deny a settlement.Mandell added that insurers would pay the settlement. 1070