济南治疗阳痿早泄最有效的药(济南男性阳痿危害) (今日更新中)

FALLBROOK, Calif. (KGTV) -- A 55-year-old man died Monday afternoon following a crash in Fallbrook, according to California Highway Patrol.The agency said the crash happened on East Mission Road west of Red Mountain Dam Drive around 1:16 p.m.CHP said a 47-year-old woman driving a Mustang drifted to the left into oncoming traffic, striking a Toyota Tacoma driven by the 55-year-old man.The driver of the Tacoma was taken to the hospital where he later died. The driver of the Mustang was also taken to the hospital for major injuries, CHP said.Officers later determined that the driver of the Mustang was under the influence of a drug. She was arrested before being released into the care of Palomar Medical Center, CHP said.The crash is under investigation. 767

Fast food sandwich chain Subway expects to close about 500 stores in North America this year.But it's also hoping to open as many as 1,000 stores overseas.The company has 44,000 locations globally -- more than any other retailer. The National Retail Federation put its US store count at nearly 27,000 as of 2016, compared to 17,500 for Yum Brands, which runs Pizza Hut, Taco Bell and KFC, and the 14,000 locations for McDonald's.The company said Wednesday it expects stores to close after it rolls out a revitalization plan, announced last summer, that will require franchise owners to invest more in their operations. All Subway stores are franchise owned, rather than owned by the company. The plans to revamp locations include adding self-service kiosks, more comfortable seating and Wi-Fi and USB charging ports. In February, Subway also announced plans for a loyalty program to win back customers and stem slumping sales.Store closings are new for Subway. It had a net loss of more than 350 US stores in 2016, the first year in the company's history that it trimmed rather than increased its number of stores. The privately held company has yet to disclose its 2017 store count, but there were reports of hundreds of store closings."Looking out over the next decade, we anticipate having a slightly smaller, but more profitable footprint in North America and a significantly larger footprint in the rest of the world," the company said on Wednesday.Many of Subway's locations are smaller compared to other fast food rivals. That's one of the reasons there are so many of them -- it's much less expensive for a franchisee to open a Subway storefront rather than one for McDonald's or Burger King.Many traditional brick-and-mortar stores have been closing locations in recent years, as people buy more goods online. But that hasn't been the case for fast food, where there is virtually no competition from online competitors.Fast food sales on the other hand are getting hit by the drop in retail foot traffic in the places like malls, as well as the growing demand for healthier food.Subway also took a public relations hit in 2015 when Subway spokesman Jared Fogle pleaded guilty to charges of child pornography and crossing state lines to pay for sex with minors. He was sentenced to more than 15 years in prison. The company had not used him in a television commercial since 2013, and it quickly cut ties with him when his legal problems became public. 2512

Experts predict over billion worth of campaign political ads will be produced in 2020. So, what are the campaigns doing to influence your vote? THE EXPERTS To find out the tactics used by campaigns, we reached out to Sara Cutter, a Republican ad maker, and Julian Mulvey, a Democratic ad maker. SECRET #1: FONTPay attention to font. Mulvey says Democrats will use a lot of red lettering in commercials against President Donald Trump. That's because it instills some fear and catches your eye. "It's what I call a black, white and red ad. Which you see a lot in negative adverting. Those are sort of the primal colors and the first color you ever see in your life is red," Mulvey said. Mulvey pointed to an ad by the Lincoln Project as an example of red lettering. SECRET #2: VOICEPay attention to the voice. Sometimes, Cutter says, ad makers will use a female voice when they are worried a claim may be too over-the-top. "There can be more fear in a females voice without it seeming to be too much. There can also be more urgency in a female's voice," Cutter said. SECRET #3: JOURNALISTS Pay attention to journalists appearing in a campaign commercial. While journalists hate appearing in ads, Mulvey says they can't sue to get their face out of them. It's also become more popular in recent years as they test well in focus groups. "Local anchors are trusted individuals," Mulvey said, defending the tactic. SECRET #4: DISTORTED PHOTOSSometimes photos of candidates are altered. A recent ad by individuals trying to re-elect Senator David Perdue made Perdue's opponent's nose look bigger. 1604

Experts say the finalization of a COVID-19 vaccine is in our near future. Dr. William Moss is a professor of epidemiology and the executive director of the International Vaccine Access Center at the Johns Hopkins Bloomberg School of Public Health.“Remarkable progress has been made in the development of COVID-19 vaccines,” Dr. William Moss said.He says it typically takes five to 10 years to develop a vaccine, but with so much money and attention going toward COVID-19, he believes it’s likely we’ll have a vaccine by the end of the year.“I’m pretty confident that there will be a vaccine that will have an emergency-use authorization in the United States by the end of 2020,” Dr. Moss said.According to Dr. Moss, of the dozens if not hundreds of vaccine candidates in clinical trials, there are three vaccine candidates that have reached phase three. Phase three is when tens of thousands of volunteers test the vaccine to make sure it’s safe and effective.As of this week, we have optimistic news regarding phase-three efficacy results from biopharmaceutical company Pfizer – which has been collaborating with German company BioNTech.“Early preliminary results suggests that their vaccine is 90% or so effective in preventing mild to moderate or severe disease.”If the 90% efficacy data holds up after follow ups from participants in late November, Dr. Moss says he expects the FDA will rigorously review the data and approve the vaccine for distribution. That means health care workers and other high-priority groups would get the vaccine in December of this year, or early next year.“Pfizer says that they could have close to 50 million doses by the end of this year," Dr. Moss said. "Now remember their vaccine – as a number of the vaccine candidates do – requires two doses per individual. So, 50 million doses allows you to vaccinate about 25 million people.”Dr. Moss says the unprecedented investment in vaccine manufacturing will make it possible for the vaccine to be distributed so quickly. However, there are still quite a few logistical challenges since he says the Pfizer vaccine requires extreme cold temperatures as low as minus 117 degrees Fahrenheit.“So we need warehouses to store the vaccine that have freezers that can maintain that cold, we need transportation systems – planes, trucks – that can deliver the vaccine and keep it cold. And then at the site of distribution, we need to be able to keep these vaccines cold.”Therefore, he says it will likely take a lot longer for the general population to get the vaccine. He’s guessing not until the middle of 2021. Of course, the idea of saving lives with the help of a vaccine is very promising, but he says the greatest misconception is that we can go back to "normal" as soon as it’s distributed.“That by no means is going to indicate that we can go back to our pre-pandemic life," Dr. Moss said. "We will not know whether these vaccines stop transmission and we’re going to still need to wear masks, to wash our hands and physically distance even when vaccines become available.”Time and patience will be vital as we wait to see the long-term impacts of the vaccine in this pandemic. 3168

Federal prosecutors announced Wednesday that they have struck a non-prosecution agreement with National Enquirer parent company American Media Inc., effectively ruling out charges for the tabloid publisher over its role in securing hush money from President Trump's longtime personal lawyer Michael Cohen.As part of the agreement, AMI admitted to making a payment of 0,000 in cooperation with members of Trump's presidential campaign in order to prevent former Playboy model Karen McDougal's claims of an affair with Trump from being made public during the 2016 race.AMI chairman David Pecker is a longtime friend of Trump's, and the Enquirer was one of Trump's most reliable and enthusiastic media boosters during the campaign.Pecker met with Cohen "and at least one other member of the campaign" in August of 2015, according to the non-prosecution agreement, which was struck with prosecutors from the office of the U.S. Attorney for the Southern District of New York."At the meeting, Pecker offered to help deal with negative stories about that presidential candidate's relationships with women by, among other things, assisting the campaign in identifying such stories so they could be purchased and their publication avoided," the agreement read. "Pecker agreed to keep Cohen apprised of any such negative stories."Details of the payment to McDougal emerged in 2016, mere days before the election, when the Wall Street Journal reported about her agreement with the Enquirer. At the time, AMI insisted that it "has not paid people to kill damaging stories about Mr. Trump." The reported agreement drew wider attention earlier this year following a story published by The New Yorker, which shed light on the tabloid practice of "catch and kill," wherein a publication purchases a story purely so it won't run. McDougal signed a contract worth 0,000, granting AMI "exclusive ownership of her account of any romantic, personal, or physical relationship she has ever had with any 'then-married man,'" the New Yorker reported.The news of the non-prosecution agreement comes the same day that Cohen was sentenced to three years in prison for his role in the matter.In a statement, the SDNY said, "Assuming AMI's continued compliance with the agreement, the Office has agreed not to prosecute AMI for its role in that payment."A spokesperson for AMI declined to comment. 2421

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