济南菜花状突起(济南霉菌性前列腺炎) (今日更新中)

A woman is recovering after being rescued by police from the basement of a Niagara Falls, New York home, where officers said she was chained.Meantime, officers are trying to locate the man they say put her there: Michael Ciskiewic, 25, of Niagara Falls. 265

A pinch in the leg, a squeal and a trickle of tears. One baby after another in Malawi is getting the first and only vaccine against malaria, one of history’s deadliest and most stubborn of diseases.The southern African nation is rolling out the shots in an unusual pilot program along with Kenya and Ghana. Unlike established vaccines that offer near-complete protection, this new one is only about 40% effective. But experts say it’s worth a try as progress against malaria stalls: Resistance to treatment is growing and the global drop in cases has leveled off. With the vaccine, the hope is to help small children through the most dangerous period of their lives. Spread by mosquito bites, malaria kills more than 400,000 people every year, two-thirds of them under 5 and most in Africa.Seven-month-old Charity Nangware received a shot on a rainy December day at a health clinic in the town of Migowi. She watched curiously as the needle slid into her thigh, then twisted up her face with a howl.“I’m very excited about this,” said her mother, Esther Gonjani, who herself gets malaria’s aches, chills and fever at least once a year and loses a week of field work when one of her children is ill. “They explained it wasn’t perfect, but I feel secure it will relieve the pain.”There is little escaping malaria -- “malungo” in the local Chichewa language -- especially during the five-month rainy season. Stagnant puddles, where mosquitoes breed, surround the homes of brick and thatch and line the dirt roads through tea plantations or fields of maize and sugar cane. In the village of Tomali, the nearest health clinic is a two-hour bike ride away. The longer it takes to get care, the more dangerous malaria can be. Teams from the clinic offer basic medical care during visits once or twice a month, bringing the malaria shot and other vaccines in portable coolers. Treating malaria takes up a good portion of their time during the rainy season, according to Daisy Chikonde, a local health worker.“If this vaccine works, it will reduce the burden,” she said.Resident Doriga Ephrem proudly said her 5-month-old daughter, Grace, didn’t cry when she got the malaria shot.When she heard about the vaccine, Ephrem said her first thought was “protection is here.” Health workers explained, however, that the vaccine is not meant to replace antimalarial drugs or the insecticide-treated bed net she unfolds every night as the sun sets and mosquitoes rise from the shadows. “We even take our evening meals inside the net to avoid mosquitoes,” she said.It took three decades of research to develop the new vaccine, which works against the most common and deadly of the five parasite species that cause malaria. The parasite’s complex life cycle is a huge challenge. It changes forms in different stages of infection and is far harder to target than germs.“We don’t have any vaccines against parasites in routine use. This is uncharted territory,” said Ashley Birkett, who directs PATH’s Malaria Vaccine Initiative, a nonprofit that helped drugmaker GlaxoSmithKline develop the shot, brand-named Mosquirix. The bite of an infected mosquito sends immature parasites called sporozoites into the bloodstream. If they reach the liver, they’ll mature and multiply before spewing back into the blood to cause malaria’s debilitating symptoms. At that point, treatment requires medicines that kill the parasites.Mosquirix uses a piece of the parasite — a protein found only on sporozoites’ surface — in hopes of blocking the liver stage of infection. When a vaccinated child is bitten, the immune system should recognize the parasite and start making antibodies against it.Scientists also are searching for next-generation alternatives. In the pipeline is an experimental vaccine made of whole malaria parasites dissected from mosquitoes’ salivary glands but weakened so they won’t make people sick. Sanaria Inc. has been testing its vaccine in adults, and is planning a large, late-stage study in Equatorial Guinea’s Bioko Island.And the U.S. National Institutes of Health soon will start initial tests of whether injecting people periodically with lab-made antibodies, rather than depending on the immune system to make them, could offer temporary protection during malaria season. Think of them as “potentially short-term vaccines,” NIH’s Dr. Robert Seder told a recent meeting of the American Society of Tropical Medicine and Hygiene.For now, only babies in parts of Malawi, Kenya and Ghana are eligible for the Mosquirix vaccine. After the vaccine was approved in 2015, the World Health Organization said it first wanted a pilot roll-out to see how well it worked in a few countries — in real-world conditions — before recommending that the vaccine be given more widely across Africa. “Everyone is looking forward to getting it,” said Temwa Mzengeza, who oversees Malawi’s vaccine programs. Those eager for the shots include her husband, whom she had to stop from trying to get them, she said.Mzengeza used to come down with malaria several times a year until she started following her own advice to sleep under a net every night. Unlike many other kinds of infections, people can get malaria repeatedly, building up only a partial immunity.In the pilot program that began last year, 360,000 children in the three countries are meant to be vaccinated annually. The first dose is given at about age 5 months and the final, fourth booster near the child’s second birthday.Experts say it is too early to know how well the vaccine is working. They’re watching for malaria deaths, severe infections and cases of meningitis, something reported during studies but not definitively linked to the vaccine.“To do something completely new for malaria is exciting,” said researcher Don Mathanga, who is leading the evaluation in Malawi. The rainy season has brought new challenges, making some rural roads impassable and complicating efforts to track down children due for a shot. So far in Malawi, the first dose reached about half of the children targeted, about 35,000. That dropped to 26,000 for the second dose and 20,000 for the third. That’s not surprising for a new vaccine, Mzengeza said. “It will pick up with time.”At the health clinic in Migowi in Malawi’s southern highlands, workers see signs of hope. Henry Kadzuwa explains the vaccine to mothers waiting at the clinic. He said there was a drop in malaria cases to 40 in the first five months of the program, compared to 78 in the same period in 2018.Even though he wishes his 3-year-old daughter, Angel, could receive the vaccine, “it’s protecting my community. It also makes my work easier,” Kadzuwa said. The Migowi area has one of the country’s highest rates of malaria, and a worn paper register in the clinic’s laboratory lists scores of cases.At the clinic, Agnes Ngubale said she had malaria several years ago and wants to protect her 6-month-old daughter, Lydia, from the disease.“I want her to be healthy and free,” she said. “I want her to be a doctor.”And she has memorized the time for Lydia’s second dose: “Next month, same date.”___Neergaard reported from Washington.___The Associated Press Health and Science Department receives 7200

Amid the COVID-19 outbreak, many schools are closing. Teachers across the country are getting creative, even taking their classrooms remote. Many schools across the country have canceled classes, but not all. Some have asked students to take their learning into their homes. One Colorado charter school is making it all happen and finding some benefits in the process. Math teacher Marilyn Hartzell has turned her kitchen into an at-home classroom.“Our group of schools decided that we would try to teach online,” Hartzell said.The school sent students home with Chrome Books in order to continue their education online.Aside from the location, the school day looks very much the same. Instead of classrooms, students are jumping from one Google chat class to the next.“I think for right now, because this is super new, the engagement is super high,” Hartzell said.There are some benefits about teaching remote.“It takes a lot longer to set up these assignments online, but in the end, the grading part and the ability to analyze the skills and what the kids are understanding is a lot faster,” Hartzell said.With technology comes challenges. Hartzell says it’s hard to ask students to fix their wifi. But, if technology fails all together, she has pre-recorded lessons and posted them on YouTube.While class for many students around the country has been postponed, Hartzell and her students are embracing remote school.“We are anticipating we probably won’t come back this school year,” she said.However, Hartzell wants everyone to keep in mind that although technology is a great tool, it doesn’t teach children. 1627

A newly proposed Ohio bill would make it punishable by law for physicians to medically aid transgender children through gender transition therapies. Two Ohio lawmakers have proposed charging physicians who do treat transgender children with a third-degree felony if they attempt therapeutic or surgical procedures to change the gender of anyone under the age of 18. It would also allow parents to sue those physicians. While the bill hasn't been formally filed yet, it's already caused concern among those who support transgender rights. "Without the medications, and the access to doctors and therapists and all this, I don't know where these children are going to turn or what they're going to do," said Jessica Cicchinelli, the mother of a transgender child. "And that, that scares me more than anything." Cicchinelli's child is one of 1,600 patients receiving treatment at Cincinnati Children's Hospital, in the Living with Change Clinic specifically designed to serve transgender children. Two doctors, a social worker and several members of nursing personnel work in the department currently. The conservative group Citizens for Community Values supports the bill and other legislation like it. Citizens for Community Values has not responded to a request for comment. Reps. Sedrick Denson and Bridgid Kelly responded, saying they do not support it. Five other state state lawmakers did not respond. Cicchinelli said the treatments her child receive are important, and help her child thrive. She's working to raise money to help fund the work that happens in the Living with Change Clinic."These lawmakers should not have the right to choose how we live our lives and the type of medication and that, you know, that we get," said Cicchinelli. The American Academy of Pediatrics and the American Medical Association say "...physicians play a role by offering a safe and inclusive place for transgender and gender diverse youth ... " 1951

Amazon said this year's Prime Day was "once again the largest shopping event" in its history.The company said sales from its 137

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