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SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459
SAN DIEGO (KGTV) -- Just beyond the gates to Richard J. Donovan Correction Facility are rows of chain-linked fence topped with razor wire.Guard towers surround the complex southeast of San Diego; signs display a warning of no trespassing.The elaborate security set-up is designed to keep inmates in, but those serving time have discovered they don't need to be beyond the walls to inflict havoc on the world outside.Inmates are using cell phones and social media accounts to try and pimp women on the outside."They will work these girls and women outside of prison," said San Diego County Deputy District Attorney Carolyn Matzger. For the past six years, she's been in the sex crimes and human trafficking division.Pimping from prison is a phrase Matzger's become all too familiar with.Team 10 investigator Adam Racusin asked Matzger if pimping from prison is a growing trend."It's something that we definitely realized is happening," she said.Matzger authored an article in "Law Enforcement Quarterly" profiling the first prison trafficking case the San Diego Human Trafficking Taskforce handled.According to the article, a detective in Arizona saw a social media profile with pictures of a man in prison clothes. "The detective, using an undercover social media account of a fake 18-year-old woman, sent a message to the inmate Wendell Bullock." "So he was serving a rape sentence and trying to work women while he was in prison," Matzger said.Court paperwork obtained by 10News shows Bullock identified himself as a pimp during the communication with the detectives. He asked if they had escorted before and told them they could make money together. Bullock made statements that the female's job was to make money and Bullock would be responsible for posting the ads and for keeping her safe.According to the documents, Bullock would tell the girls what to say on the phone and what to look out for. Bullock told one of the females that she would not be having sex for less than 0."It's the promises they make of, 'Hey this is a quick buck. You could make good money doing this. I believe in you,'" Matzger said. "They often say to these women, 'I believe in you.'"This scheme ended with Bullock pleading guilty. He got an additional 10 years behind bars for pandering.In his plea agreement, Bullock wrote that he unlawfully encouraged the undercover detective to become a prostitute by using promises or device or scheme."If you have a human being and you are able to sell that person over and over and over again, that's very very lucrative," Matzger said.A state corrections official told 10News "contraband cell phone usage is a problem that CDCR takes very seriously.""Cellphone use by inmates can pose a security risk. Modern cell phones can record video and audio, and connect to the Internet. Additionally, contraband cellphones in state prisons can be used to facilitate or commit crimes, including illicit gang activity," said Vicky Waters, CDCR Press Secratary."The department has implemented many strategies to curb introduction and use of contraband cellphones, including the Managed Access System (MAS) or jamming/interruption technology, K-9s trained to detect cellphones, the use of parcel scanners, low-dose full-body scanners, metal detectors, etc., which provide a good foundation for preventing contraband from entering the institutions. Also, under CDCR regulations, inmates are prohibited from internet access. Thus, this implicitly bars inmates from access to social media since internet access is required in order to access such social media. Given the prohibition on internet access and also the fact that inmates are barred from possessing cellphones or wireless communication devices, the manner in which California inmates access social media is in violation of the law," said Waters.In the San Diego County region, sex trafficking is an 0 million business annually.Traffickers can make anywhere from half a million dollars on up.The average age of someone who's recruited is 16-years-old.Matgzer says kids are recruited from every neighborhood in the county. As for what motivates the pimps, Matzger won't speculate. In prison, inmates have a lot of time and are looking for ways to make money, says Matzger.Despite being behind bars, inmates can still have a lot of influential power inside and outside the correctional facility."They can do these blasts really quick for them to reach a lot of people and they only need one or two people to bite, and then they've got a business," Matzger said. Since Bullock's case, the human trafficking task force investigated four inmates in three other state prisons who are suspected of using cell phones to traffic.Two of those inmates have already been brought to San Diego County to be prosecuted.If you're a victim or know someone, there's help out there. Call the National Human Trafficking Hotline toll-free hotline at 1-888-373-7888. Anti-Trafficking Hotline advocates are available 24/7 to take reports of potential human trafficking. Text the National Human Trafficking Hotline at 233733. Chat the National Human Trafficking Hotline at www.humantraffickinghotline.org/chat. 5178
SAN DIEGO (KGTV) -- Millions of Americans owe more on their homes than they’re actually worth in the first quarter of 2019, according to a new report by Attom Data Solutions. San Diegans, on the other hand, are sitting on equity rich properties. In the U.S. as a whole, more than five million homes were seriously underwater, meaning property owners owe at least 25 percent more than the home is worth. RELATED: Teachers, first responders struggling to afford housing, report saysAlthough the report paints a grim picture for millions of Americans, San Diegans are seeing the opposite. According to the report, nearly 40 percent of properties in San Diego are equity rich, meaning property owners had at least 50 percent equity. In California, 43 percent of properties are equity rich. Other states that fared well include Hawaii, New York, Washington and Vermont. RELATED: City receives financial boost for Section 8 housingNationally, however, more than 9 percent of all U.S. properties with a mortgage are seriously underwater. In several places around the country, more than half of all properties are seriously underwater, according to the report. Those locations include Milwaukee, Trenton, Chicago, St. Louis and Cleveland. 1240
SAN DIEGO (KGTV) — In response to the coronavirus pandemic, Qualcomm is requiring employees able to work from home to do so.In an email sent to employees, the company moved to "a global required work from home policy for employees who are able to perform their job remotely" effective immediately through March 27. A Qualcomm spokesperson confirmed the email to 10News.The company email says employees in China should continue to follow local guidelines that they've received separately."Certain employees will be identified as 'onsite critical,' which means that your work is both critical to the continuity of business operations and requires onsite presence to perform your work duties," the company's email read.Qualcomm said it is taking the action as a "proactive, preventative measure to protect our employees and help reduce the spread of the virus."The San Diego Regional Economic Development Corporation estimated in early 2018 that the company has a .9 billion impact on the San Diego economy. Founded in 1985, Qualcomm is one of San Diego's largest employers, employing more than 33,000 people worldwide. 1126
SAN DIEGO (KGTV) -- Many Black female voters in San Diego voters are celebrating Joe Biden’s decision to choose California Sen. Kamala Harris as his running mate.“This is a historic moment. I’m excited that I’m alive to see this happen,” said Ellen Nash, the chair of the San Diego chapter of the Black American Political Association of California.“All along that was the right choice,” Nash told ABC 10News. “I’m honored that she’s there to represent Black women and the Black vote. For Joe Biden to honor us by selecting her as his VP is the greatest historic moment.”Many Black voters wrote to Biden, urging him to choose Harris.Nash said having Harris as the first Black and Asian American woman to appear on a major party’s presidential ticket gives women of color a voice.“It was just a moment of relaxation and celebration,” said Nash. “She is prepared, skilled, and credentialed.”But does this choice possible boost Biden’s chances of winning this election? Dr. Kyra Greene, the executive director at the Center on Policy Initiatives, said Harris would bring new life to this race while appealing to a wide range of voters.“She’s young enough to attract young folks but old enough to show experience and to be taken seriously,” said Greene. “I think it will help with women who were disappointed not to see other women advance further in this race, and I also think it will help with Black voters.”“I think Senator Harris speaks to people who are interested in change because she herself has gone through an evolution on these issues,” she said.Greene said the decision not only makes history but will reenergize some of the most politically engaged San Diegans. 1678