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The world's biggest COVID-19 vaccine test got underway Monday with the first of 30,000 planned volunteers. The experimental vaccine is made by the National Institutes of Health and Moderna Inc. It's one of several candidates in the final stretch of the global vaccine race. Officials are seeking to find out whether more people who get dummy shots become infected than those given two doses of the real vaccine. The U.S. government plans separate huge studies of several leading vaccine candidates through fall, each in hot spots where the virus still is spreading.Dr. Anthony Fauci and other Trump administration officials have said that the company is already producing millions of doses of the vaccine in the event that it receives Emergency Use Authorization from the FDA following the trial. Fauci remains cautiously optimistic that a vaccine could be available by January of next year — though it's unclear how long it would take for a vaccine to be available for all Americans who want it. 1004

The US-backed Syrian Democratic Forces have detained a US citizen who had been fighting with ISIS in Syria, a US military official told CNN Thursday.The official added that it appeared that the American citizen surrendered to Kurdish elements of the Syrian Democratic Forces.A spokesperson for the US-led coalition fighting ISIS would not confirm that a US citizen was in the custody of the SDF, referring questions to the US State Department."We have seen those same reports and the SDF as our partner has taken an oath to make sure that any fighters that they capture that they maintain them and bring them to the proper authorities. In this case the proper authorities would be the equivalent of the department of state in the country," Col. Ryan Dillon told reporters at the Pentagon via a video conference from Baghdad."If this was a US citizen it would be the Department of State to find out the updates on that particular person," Dillon added.A State Department official told CNN that the department was aware of the reports but said that they "have no information to share at this time."The Justice Department and the FBI also declined to comment.The Daily Beast was first to report that a US citizen had been detained by the SDF.This isn't the first US citizen fighting for ISIS to be detained by US allies in the region. In March 2016 a US citizen was captured in Iraq by US-backed Kurdish Peshmerga forces.The number of US citizens traveling to Iraq and Syria to join ISIS is thought to be much smaller than other countries and regions such as Western Europe and coalition officials have noted that far fewer foreign fighters have joined ISIS in recent months as the terror group suffers set-backs on the battle field.ISIS' recent defeats have also caused an increase in the number of fighters surrendering to the SDF with Dillon telling reporters that five ISIS fighters, including a local commander, had surrendered this week alone.The-CNN-Wire 1966

The United States Coast Guard embodies the saying, "always ready."When forecasting natural disasters, however, those two words become much more than a motto -- they could mean the difference between life and death.“With natural disasters, they’re unpredictable," said USCG Capt. Will Watson, commander, Sector New Orleans. "There’s uncertainty but what you have to do is lean back on your training.” With U.S. Coast Guard stations across the country on standby, Watson said his teams are ready to help whenever and wherever they are needed.“When the time comes, and you face something that you maybe weren’t otherwise prepared for, that’s when you exercise on-scene initiative,” he said. “You think critically. You think creatively. Remain adaptable and flexible and act.”Southeast Louisiana locals are calling the U.S. Coast Guard, “heroes,” saying they saved more than lives during past natural disasters.“One day, I got stuck in a boat and they come over here, five of them come here, and helped me out,” said local fisherman Tony Buffone, who lost his house during Hurricane Katrina -- one of the most deadly and expensive natural disasters to hit U.S. soil.During recent storms, Buffone is now using lessons he learned from the U.S. Coast Guard.“It’s good to have good Coast Guard,” he said. “We got a good Coast Guard crew right there.”As the Gulf Coast deals with another massive hurricane, the U.S. Coast Guard is doing what it does best: staying “always ready”.“We have resources, assets, people from all across the Coast Guard ready to support this fight,” Watson said. “And we’re ready; ready to respond to Hurricane Laura.” 1643

The White House physician assigned to Vice President Mike Pence, Jennifer Pena, has resigned, his office told CNN in a statement Friday. Pena worked in the White House medical unit."The vice president's office was informed today by the White House Medical Unit of the resignation. Physicians assigned to the vice president report to the White House Medical Unit and thus any resignation would go entirely through the Medical Unit, not the vice president's office," Alyssa Farah, Pence's press secretary, said in a statement to CNN.This comes after CNN reported Tuesday that a Pence doctor privately raised alarms within the White House last fall that President Donald Trump's doctor Ronny Jackson may have violated federal privacy protections for a key patient -- Pence's wife, Karen -- and intimidated the vice president's doctor during angry confrontations over the episode.  890

The U.S. reported yet another daily high mark for newly reported cases of COVID-19 on Thursday with nearly 188,000, according to a database kept by Johns Hopkins University.The U.S. reported at least 187,833 positive COVID-19 tests on Thursday, breaking the all-time record of 177,224 that was set six days prior, on Nov. 13.Thursday marked the eighth time in November that the U.S. broke the daily record for newly reported cases as the COVID-19 continues to spread across the country. About 2.5 million people in the U.S. have contracted the virus since the start of November.The spike in cases has led to all-time highs in hospitalizations linked to the virus. The COVID Tracking Project reports that more than 80,000 people are currently hospitalized with the virus across the country — an all-time record that surpasses even the early portions of the pandemic. According to the COVID Tracking Project, 71% of those hospitalizations occur in the Midwest and South, leading to many rural hospitals running short on resources. Some states like South Dakota and Iowa say their hospitals are at their breaking points.Thursday also saw reports of 2,000 deaths linked to the virus — the first time the U.S. has seen that many reported deaths in a single day since May 6. Since Oct. 17, daily deaths linked to COVID-19 on a seven-day rolling average have nearly doubled from about 700 a day to more than 1,300 a day. The continued spike comes amid a rash of promising news in the hope for a COVID-19 vaccine. On Friday, Pfizer announced that it had filed for Emergency Use Authorization for its vaccine candidate, two days after initial studies showed it to be 95% effective in large-scale trials. Several other drugmakers have also reported that their vaccines are on the precipice of authorization.However, health experts warn that the U.S. is in for a rough few months. Vaccines will initially need to be rationed for people in high-risk populations and health care workers. Dr. Anthony Fauci has said he believes vaccines won't be widely available until April. 2075