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SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) -- The Golden Knights offered a spectacular preview aboard the USS Midway, landing on the flight deck. The event was part of the museums Army Day celebration. The day began with an enlistment ceremony. A Japanese-American World War II veteran read the oath of enlistment to the Army’s newest recruits. The celebration marks the first event of its kind aboard the Midway. The Golden Knights will also fly during the opening ceremonies at the Miramar Air Show Friday morning at 11:45 a.m. Click here for more information on the air show. 561

SAN DIEGO (KGTV) — The "Capital of Craft" made its name known at the Great American Beer Festival in Colorado this weekend.San Diego breweries took home 17 medals from the massive festival, which features blind-taste testing of nearly 9,500 beers from almost 2,300 breweries. Since the first festival in 1982, San Diego breweries have grabbed 233 medals.At this year's event, local breweries claimed eight gold, four silver, and five bronze medals at the annual brew competition. Here's where you can try the award-winning ales:GoldAleSmith Brewing Co.: Private Stock Ale (Old Ale or Strong Ale)Breakwater Brewing Co.: Rye Dawn (Rye Beer)Pizza Port – Bressi Ranch: Chronic Amber Ale (Ordinary or Special Bitter)Pizza Port – Solana Beach: SeaSide Stout (Classic Irish-Style Dry Stout)Second Chance Beer Co.: Tabula Rasa (Robust Porter)SouthNorte Beer Co.: Sea Se?or! Mex Lager (American-Style Cream Ale)The Lost Abbey: A Creator’s Calling (Aged Beer)Two Roots Brewing Co.: Enough Said N/A (Non-Alcoholic or Alcohol Free Beer)SilverCoronado Brewing Co.: Freebooter Barleywine (Barley Wine-Style Ale)SouthNorte Beer Co.: Agavemente (Specialty Beer)Stone Brewing World Bistro & Gardens – Liberty Station: Stone Liberty Station Cimmerian Portal (American-Style Stout)Thunderhawk Alements: Bowie Knife (American-Style Black Ale)Saint Archer Brewing Company: Citra Pilsner (Contemporary American Style Pilsner)BronzeChula Vista Brewery: Browner Than Ivan (American-Style Brown Ale)Coronado Brewing Co. – Production Facility: Weekend Vibes IPA (American-Style India Pale Ale)Kilowatt Brewing: OB Bubble Dubbel (Belgian-Style Dubbel)Resident Brewing Co.: Industrial Gris (Belgian- and French-Style Ale)Rip Current Brewing: Rescue Buoy Imperial Stout (Imperial Stout)"The San Diego Brewers Guild is extremely proud of San Diego’s consistently strong showing at GABF," said Kris Anacleto, Vice President of San Diego Brewers Guild. "“It is because of our craft beer community’s pioneering spirit and innovation that San Diego’s craft beer legacy continues to thrive in today’s hyper-competitive national landscape."The accolades help reaffirm San Diego's reputation for craft beer. In 2018, the local craft beer industry accounted for .2 billion in economic impact on the region.San Diegans will surely have the chance to enjoy some of the award-winning brews and more soon enough during San Diego Beer Week, taking place Nov. 1 - 10. 2437

SAN DIEGO (KGTV) - The California Attorney General’s office sent a warning to HiCaliber Horse Rescue in Valley Center, days after a Team 10 investigation into the group’s practices.The rescue is delinquent with the Registry of Charitable Trusts for failing, in part, to submit its 2016 taxes, according to the Attorney General’s office.HiCaliber told Team 10 investigator Jennifer Kastner it was honest mistake that’s being addressed.RELATED: Questions of fraud and abuse at prominent horse rescueThe group told 10News it received an extension on its 2016 taxes because of a personal emergency.The rescue recently came under fire for euthanasia and questionable fundraising practices. 692

SAN DIEGO (KGTV) - The La Boheme complex in the heart of North Park offers plenty of amenities. It even has a salon and Pilates studio at street level. "Pretty sure the rent's pretty up there," said Arthur Reynoso, walking by the building on Thursday. What most people don't know, however, is that 45 of the 224 condos in the building are affordable - to own. It's rare for one to come on the market, but a handful do each year. In fact, one is about to sell for 5,341, which is about 40 percent off the median condo price of 6,000 in North Park. RELATED: Making It In San Diego: How housing got so expensive"They get snapped up very quickly," said Sujata Raman, director of housing finance at the San Diego Housing Commission. The commission oversees about 250 for-sale affordable homes in San Diego - located in Carmel Valley, Black Mountain Ranch and North Park. Only four are for sale now, and Raman said all have been matched with buyers. However, they can list anytime. RELATED: Making it in San Diego: Key saving steps helped renter buy her first home"When a homeowner decides to sell we assist them by finding buyers because they ultimately have to be income approved and qualified by the housing commission," Raman said. A homeowner can sell the property to anyone he or she wishes - so long as they are qualified - but the commission still maintains an interest list and is accepting applicants. Currently, there are about 275 households qualified for that list. The homes are not listed on the MLS. Still, there are restrictions when owning one of these units. Owners must live in them, and cannot rent out any part to supplement income. The commission checks that annually. Qualified buyers usually have 60 to 110 percent of area median income. RELATED: Making It in San Diego: Best and worst places in San Diego County for home resaleBuyers must come up with a 3 percent down payment to qualify. The homes are deed-restricted for generally 45-50 years, meaning they have to be sold at an affordable price for that time span. However, once that time expires, that home becomes market rate and can be sold for any price. It doesn't reset once a property changes hands. 2194