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A surge in COVID-19 cases is further straining the already-depleted supply of prescription drugs in the U.S., according to researchers and doctors at the University of Minnesota."The supply lines are really stressed and stretched," said Dr. Stephen Schondelmeyer, a co-principal investigator for the Resilient Drug Supply Project at the University of Minnesota.Schondelmeyer's work focuses on critical drugs and their supply chains. He tracks the supply chain process for every drug on the marketplace — more than 100,000 in total.Most of the prescription drugs used by Americans are made outside of the country — meaning the U.S. is reliant on foreign companies to manufacture the drug and shipping companies to deliver them safely."We're identifying where it comes from — the first thing you need to know is about 70% of all the drugs that come into the U.S. marketplace are made outside of the US.," Schondelmeyer said.He and his team want to predict and identify when and where there will be failures in the system. Right now, the U.S. has a "fail and fix" system — and right now, there are some critical breakdowns in the supply chain."Seventy-five percent of the COVID-19 drugs are currently in shortage," Schondelmeyer said. "That means three-fourths of the drugs we're using for COVID-19 were already in shortage, and that's before we had this last surge we're seeing.""We should, as a matter of national policy, have a map like we're building of the global drug supply from the beginning all the way until the drug reaches the patient," Schondelmeyer said.But it's not just COVID-19 drugs that are in short supply. Dr. Beth Thielen, an assistant professor of pediatrics at the University of Minnesota Medical School and an infectious disease physician, says even some routine drugs are hard to come by."As a physician working in the hospital — the University of Minnesota — we're a big urban center and yet we're regularly dealing with this issue of shortages in routine things like antibiotics," Thielen said. "It's very concerning to think about the supply chain breaking down and seeing drugs not available in pharmacies or the hospital."Doctors say COVID-19 has unmasked a problem that's been a concern for decades. The pharmaceutical supply chain is complicated and dependent on other countries — and there are supply and demand dilemmas."Start the conversation now with your healthcare provider," Thielen said. "There might be some within class substitutions of medicines, so a drug that is related may not be the exact same drug but might fulfill the same purpose."Schondelmeyer adds that anyone with a regular prescription should ask their doctor about getting a 90-day supply of essential drugs — but adds that there's no reason to hoard medication."We shouldn't panic. We shouldn't treat drugs like we did toilet paper and stock up on so much that we're totally out — and that's an example of what can happen when there's rumors of shortages," Schondelmeyer said. "People act out of fear, and they hoard more than they really need."In the meantime, Schondelmeyer is pushing for a national stockpile of critical medications, so that the U.S. is covered should there be a complete breakdown in the supply chain. 3236

A sniper who targeted cars on a Georgia highway left behind a "hate-filled" document describing the Parkland high school gunman Nikolas Cruz as a hero, a sheriff said.Authorities identified the sniper as Rex Whitmire Harbour, 26, of Snellville, Georgia.He shot at cars in Gainesville on Friday, leaving three people injured before he shot himself dead, Hall County Sheriff Gerald Couch said in a statement Saturday.Harbour hid in the woods as he waited for motorists on the side of Georgia 365, Couch said. He fired at least 17 times and hit seven cars, wounding two men in the hip and leg. A third person -- a woman -- was slightly injured by broken glass, authorities said.The two men suffered injuries that are not life-threatening, and are in stable condition. 782

A Thanksgiving night shooting at a mall in Alabama left two people injured and a gunman dead, authorities said Thursday.The incident at the Riverchase Galleria in Hoover started with a physical altercation between an 18-year-old and the 21-year-old gunman, police said. The confrontation occurred in the mall, near Footaction and JC Penney stores.Police do not know how the confrontation began, but "we do not believe at this point the 18-year-old was armed," Hoover police Capt. Gregg Rector said.The gunman opened fire, shooting the teen twice in the torso, according to police. An officer confronted the gunman as he ran away from the scene and fatally shot him, Rector said.The officer involved has been placed on administrative leave while the Jefferson County Sheriff's Office investigates the incident, police said.A 12-year-old girl was also struck and injured, but it's unclear by whom, Rector said. The two people injured have been hospitalized.The girl had a single gunshot wound and has gone through surgery and "does not have life-threatening injuries," Rector told CNN.Witnesses described hearing gunshots inside the mall, which was open late on Thanksgiving. The scene was chaotic, with customers screaming and staff working to lock down the shopping center, witnesses told CNN affiliate WBRC.The Hoover Police Department said the scene is now secure.Hoover is about 10 miles from Birmingham.Brookfield Properties, which owns the shopping center, said it was devastated by the shooting."We are working closely with the Hoover Police Department and are grateful for their swift action to contain the situation," spokeswoman Lindsay Kahn said."While there is no current danger to our community, the shopping center will remain closed for tonight." 1768

A stampede of Central American migrants rushed to the tracks Saturday when the first whistle of the train rang out.After a few days in Mexico City, it was time to continue their journey north to the US border. About 500 migrants traveling in a caravan climbed onto the freight train just outside the Mexican city of Tultitlán. 334

A man who tried to enter a teenage girl's bathroom stall was confronted and killed by the girl's father, officials say. According to Phoenix police, around 11:30 p.m. on August 2, 40-year-old Melvin Harris went to the QuikTrip near Dunlap and 19th avenues to pick up his teenage daughter and her friends. A man, who would later become the victim, approached Harris' car in the parking lot and asked for money. Harris gave him some money, and he went into the QT. Harris was later informed that a man tried to enter the bathroom stall his daughter was using. The teen told an employee, who in turn alerted an on-duty security guard. The man exited the store and was pointed out to Harris, who realized it was the same man he had given money to earlier. Harris went into the store and told the security guard that, "he needed to take care of the situation, or [Harris] would do it himself." The guard reportedly told Harris he would handle it. According to witnesses, Harris later approached the man and punched him in the face. Witnesses also reportedly told police that Harris stood over him, hitting him in the face several more times. He also allegedly kicked and stomped on him. Harris then left the area. Police identified and located Harris at his home nearby. He reportedly told police that the man punched him first, hitting him in the neck. He denied striking the man when he was down. The victim was taken to the hospital with a broken nose and brain injuries. He later died.Harris has been charged with second-degree murder. 1612

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