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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

RIO DE JANEIRO, Oct. 11 (Xinhua) -- The World Health Organization (WHO) on Tuesday highlighted Brazil's efforts to stop tuberculosis (TB) in its territory.According to a report released by the organization, Brazil achieved significant and sustained improvement in the fight against TB in the past years.Along with Cambodia, China, Uganda, and Tanzania, Brazil is one of the five nations which succeeded in reducing TB death rate in 2010 by half compared with 1990.The number of TB cases in the world fell for the first time in 2010, said the WHO. But with 8.8 million cases, the disease remained a major global health problem, said the organization.Although the TB death rate had significantly dropped over the years, the disease killed 1.4 million people around the world in 2010 alone.

BEIJING, Jan. 1 (Xinhua) -- The public on Sunday strongly echoed Chinese President Hu Jintao's New Year address broadcast on Saturday, vowing to make great efforts for rejuvenation of the nation, a better future.In his speech titled "Jointly Improve World Peace and Development," Hu said that China will continue to develop friendly exchanges with other countries and positively participate in international cooperation on global issues.The country will continue to balance maintaining steady and relatively fast economic growth with adjusting its economic structures and managing inflation expectations, Hu said in the speech.PROUD Of COUNTRY'S ACHIEVEMENTS"We have been encouraged by President Hu's address, said Wang Laihua, head of the public opinions research institute of Tianjin Social Sciences Academy."His address summarized the achievements that we have made in the first year of the 12th Five-Year Plan, which raised people's expectation for prosperity, happiness," said Wang.Hu said in the address that in the face of complicated international situations and arduous tasks in maintaining domestic reform, development and stability in 2011, Chinese people united and continued to push forward the opening up and reform drive and the socialist modernization construction, while maintaining steady and relatively fast economic growth and making progress in building a well-off society in an all-around way.Zhu Jianfang, chief economist of CITIC Securities, said that the country's macroeconomic control has made positive achievements in the last year, as the prices of properties and commodity have been effectively controlled."We feel reassured after hearing Hu's speech," said Wen Jun, who has come to south China's Guangzhou for business from Hong Kong for 16 years, referring to Hu's speech saying that China will stick to the guidelines of "one country, two systems," "Hong Kong people governing Hong Kong," "Macao people governing Macao," and a high degree of autonomy in maintaining the long-term prosperity and stability of Hong Kong and Macao.

来源：资阳报