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WASHINGTON, Sept. 14 (Xinhua) -- Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published Wednesday in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells.Led by Yale Professor Hugh Taylor, the researchers bathed endometrial stem cells in cultures containing special nutrients and growth factors. Responding to these substances, the endometrial stem cells adopted the characteristics of beta cells in the pancreas that produce insulin. Over the course of a three- week incubation process, the endometrial stem cells took on the shape of beta cells and began to make proteins typically made by beta cells. Some of these cells also produced insulin.After a meal, the body breaks food down into components like the sugar glucose, which then circulates in the blood. In response, beta cells release insulin, which allows the body's cells to take in the circulating glucose. In this study, Taylor and his team exposed the mature stem cells to glucose and found that, like typical beta cells, the cultured cells responded by producing insulin. The team then injected diabetic mice with the mature, insulin-making stem cells. The mice had few working beta cells and very high levels of blood glucose.Mice that did not receive the stem cell therapy continued having high blood sugar levels, developed cataracts and were lethargic. In contrast, mice that received the cell therapy were active and did not develop cataracts, but the animals' blood sugar levels remained higher than normal.The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.Taylor said in a statement that the next step in the research will be to verify how long this treatment remains effective.
LOS ANGELES, June 5 (Xinhua) -- A latest study has found no evidence that screening for ovarian cancer may reduce the risk of dying from the disease, it was reported on Sunday.Screening, however, does increase the likelihood of unnecessary invasive procedures, according to researchers at the University of Utah.The researchers presented their findings at an on-going meeting of the American Society of Clinical Oncology in Chicago, The Los Angeles Times said.Researchers studied 78,216 women, ages 55 to 74, who participated in the National Cancer Institute's Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Half of the women received the usual care from their OB-gyns, and half received a CA 125 screening every year for six years and an ultrasound every year for four years. They were then followed for a maximum of 12 years.The researchers observed 212 ovarian cancers in the screened group and 176 in the normal care group. There were 118 ovarian cancer deaths in the screened group and 100 in the normal care group. The differences were not statistically significant. Overall, there were 2,924 deaths from all causes in the screened group and 2,914 in the normal care group.But the researchers also observed that 3,285 women had false- positive diagnoses from the screening. Among those, 1,080 underwent surgery that included an oophorectomy (surgical removal of one or both ovaries). Fifteen percent of those who had surgery developed major complications as a result. Overall, 1,771 women in the screened group (7.7 percent) had an oophorectomy, compared with 1,304 in the normal care group (5.8 percent)."We conclude that annual screening for ovarian cancer ... does not reduce disease-specific mortality in women at average risk for ovarian cancer but does increase invasive medical procedures and associated harms," the researchers said in the study.New data presented at the meeting also showed that the widely used cancer drug Avastin can improve treatment of ovarian cancer, The Times said.About 21,880 American women are diagnosed with ovarian cancer each year and about 13,850 die from it, according to the American Cancer Society. Because it produces few symptoms, the disease is typically not diagnosed until it has become advanced and spread throughout the body. As a result, five-year survival is only about 30 percent, and the disease is one of the five most deadly cancers among women. Being able to detect the cancer at an earlier stage when it might be more curable could thus, theoretically, improve the survival rate.The tests most commonly used to detect ovarian cancer include a transvaginal ultrasound to look for tumor masses and a blood test that screens for increased levels of a tumor marker called CA 125.
WASHINGTON, Aug. 18 (Xinhua) -- Using integrated radar observations from a consortium of international satellites, NASA-funded researchers have created the first complete map of the speed and direction of ice flow in Antarctica, the U.S. National Aeronautics and Space Administration (NASA) announced Thursday.The map, which shows glaciers flowing thousands of miles from the continent's deep interior to its coast, will be critical for tracking future sea-level increases from climate change."This is like seeing a map of all the oceans' currents for the first time. It's a game changer for glaciology," said Eric Rignot of NASA's Jet Propulsion Laboratory and the University of California (UC), Irvine. Rignot is lead author of a paper about the ice flow published online Thursday in Science Express. "We are seeing amazing flows from the heart of the continent that had never been described before."Rignot and UC Irvine scientists used billions of data points captured by European, Japanese and Canadian satellites to weed out cloud cover, solar glare and land features masking the glaciers. With the aid of NASA technology, the team painstakingly pieced together the shape and velocity of glacial formations, including the previously uncharted East Antarctica, which comprises 77 percent of the continent.Like viewing a completed jigsaw puzzle, the scientists were surprised when they stood back and took in the full picture. They discovered a new ridge splitting the 5.4-million-square-mile landmass from east to west.The team also found unnamed formations moving up to 800 feet annually across immense plains sloping toward the Antarctic Ocean and in a different manner than past models of ice migration."The map points out something fundamentally new: that ice moves by slipping along the ground it rests on," said Thomas Wagner, NASA's cryospheric program scientist in Washington. "That's critical knowledge for predicting future sea level rise. It means that if we lose ice at the coasts from the warming ocean, we open the tap to massive amounts of ice in the interior."
PARIS, Aug. 19 (Xinhua) -- Marine scientists and representatives from the private sector and military establishments would meet at UNESCO at the end of this month to measure noise's impact on marine life, the Paris-based UN scientific branch UNESCO said Friday.The main agenda of the meeting, which is due from Aug. 30 to Sep. 1, was to discuss the program of the International Quiet Ocean Experiment (IQOE)."This decade-long project aims to fill the considerable knowledge gaps in this area, so that management of ocean noise can be more informed and effective," UNESCO said in a statement.The Quiet Ocean Experiments was initiated against the background that human activities on the high seas have increased significantly in recent decades, and resulted in impact upon many marine species relying mainly on sound to communicate.However, some sounds are suspected to alter the behavior of marine animals. For example, several whale species have raised the volume of the squeaks, clicks and moans by which they communicate with each other.The experiment is organized by the Scientific Committee on Oceanic Research (SCOR) and the Partnership for Observation of the Global Oceans (POGO), of which UNESCO's Intergovernmental Oceanographic Commission (IOC) is a member.
BEIJING, June 10 (Xinhua) -- The nation's drug watchdog on Friday publicized a draft national standard of sulfur dioxide residue in Chinese herbal medicine, which is open for public opinion until Sept. 9 this year.The maximum amount of sulfur dioxide residue is 400 mg in one kg of each of 11 specified kinds of herbal medicine, such as Chinese yams, Gastrodia elata and Codonopsis pilosola, according to the draft standard unveiled by the State Food and Drug Administration (SFDA).The standard provides a 150-mg-per-kg limit for all other kinds of herbal medicine.Fumigation with sulfur is used as a way of drying some herbal medicine by growers, and currently have no alternative that is both cheap and convenient.The SFDA said it doesn't favor the drying herbal medicine through fumigation with sulfur and urges research efforts to invent new alternatives.According to the World Health Organization, the tolerable maximum amount of sulfur dioxide that a human body can take in one day is 0.7 mg per kg, which means that an adult of 60 kg should not take in more than 42 mg of sulfur dioxide a day.Long-term exposure to high amounts of sulfur dioxide can cause damage to human body, especially the respiratory system, according to experts.