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Supporters of right-to-try argue that the legislation is needed because most terminal patients are too sick to be selected to participate in clinical trials and it takes too long for promising treatments to be approved.Joffe argued that the right-to-try approach to providing access to unapproved drugs early in their development could put patients in harm's way, as patients receiving the drug are often in very fragile health, doctors often lack the information needed to administer the drugs safely, and little may be known about their risks and benefits, he said.Joffe pointed to certain stem cell therapies as treatment approaches that appear promising but have turned dangerous when unregulated."Another thing I'm worried about is that there's going to be a bunch of shady actors that are going to pop up that are going to start to try to take advantage of the right-to-try law to say 'we can provide these sort of experimental therapies, if you want to call them that, to patients without needing to go through the FDA,'" Joffe said."We've already seen some of that in the stem cell clinics popping up around the country that try to provide stem cell treatments for a host of problems: eye problems, heart problems," he said. "While there are legitimate efforts to develop effective stem cell therapies, a lot of these clinics that are popping up around the country that are poorly regulated are taking people's money and they are hurting people."On the other hand, the treatments available under right-to-try laws are already in clinical trials, Coleman said, adding that "this law isn't replacing the existing FDA expanded access program; it's just opening up another avenue.""No person is going to be forced to take an investigational drug. No doctor is going to be forced to request an investigational drug, and no drug company is forced to provide an investigational drug, if they don't think it's the right fit for a patient," she said."It's only for people who say, 'I understand the risk. I know this drug is not fully approved. It may not help me, but my doctor and the drug company think it could, and I want to try,'" she said. "Basically, if the FDA says that a drug is safe enough to be used in trials on humans, then it's safe enough for a dying person to make their own choice about whether or not they would like to try it when they can't get into a clinical trial." 2395
Sleiman sells his butter lettuce to 20 stores around San Diego. On Tuesday, he got an email from many of the buyers telling all farmers to not send any romaine lettuce and “trucks should be turned around immediately; everything’s being dumped and destroyed on site.” 266

Some say the tweeted video is retaliation for Acosta's sparring with Trump.The allegedly edited video was first shared by Paul Joseph Watson, who is known for his conspiracy-theory videos on Infowar, a far-right website. 230
The 39-year-old victim, who told police he did not know whoever shot him, suffered a gunshot wound to his leg. He was taken to the hospital, but his injury was not believed to be life-threatening. 196
State Department of Corrections and Rehabilitation officials said 27-year-old Justin Franks, considered a minimum-security inmate, escaped from the Northern California prison on Dec. 22. 186
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