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U.S. government officials are putting an early end to a study testing an Eli Lilly antibody drug for people hospitalized with COVID-19 because it doesn’t seem to be helping them.Independent monitors had paused enrollment in the study two weeks ago because of a possible safety issue. But on Monday, the National Institute of Allergy and Infectious Diseases, which sponsors the study, said a closer look did not verify a safety problem but found a low chance that the drug would prove helpful for hospitalized patients.It is a setback for one of the most promising treatment approaches for COVID-19. President Donald Trump received a similar experimental, two-antibody drug from Regeneron Pharmaceuticals Inc. on an emergency basis when he was sickened with the coronavirus earlier this month.In a statement Lilly notes that the government is continuing a separate study testing the antibody drug in mild to moderately ill patients, to try to prevent hospitalization and severe illness. The company also is continuing its own studies testing the drug, which is being developed with the Canadian company AbCellera.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. The experimental drugs are concentrated versions of one or two specific antibodies that worked best against the coronavirus in lab and animal tests.Lilly and Regeneron have asked the U.S. Food and Drug Administration to grant emergency use authorization for their drugs for COVID-19 while late-stage studies continue. Lilly says its request is based on other results suggesting the drug helps patients who are not hospitalized, and that it will continue to seek the FDA’s permission for emergency use.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 1928
Two dozen workers at an Amazon fulfillment center in New Jersey were taken to hospitals Wednesday after an aerosol canister of bear repellent fell off a shelf and discharged fumes inside the building, a spokesperson for Robbinsville Township told CNN, citing a preliminary investigation.Employees reported experiencing difficulty breathing and burning sensations in their eyes and throat, said John Nalbone, spokesperson for Robbinsville Township, where the fulfillment center is located.Emergency personnel responded to a morning 911 call that 54 workers at the fulfillment center were experiencing symptoms, Nalbone said. Twenty-four workers were taken to local hospitals, including one in critical condition, he said.It appears to be an accidental dispersal, he said, adding EMS is still on scene conducting triage.Bear repellent spray is similar to a can of pepper spray and is intended to deter an aggressive or charging bear. The US Fish and Wildlife Service recommends bear repellent spray as both safer and more effective than a firearm in fending off bear attacks.Rachael Lighty, regional manager for external communications for Amazon Operations, said a damaged canister caused the problem."Today at our Robbinsville fulfillment center, a damaged aerosol can dispensed strong fumes in a contained area of the facility," she said."The safety of our employees is our top priority, and as such, all employees in that area have been relocated to safe place and employees experiencing symptoms are being treated onsite. As a precaution, some employees have been transported to local hospitals for evaluation and treatment. We appreciate the swift response of our local responders."Nalbone said the call came in at approximately 8:50 a.m. to the Robbinsville EMS/911 system. One wing of the 1.3 million square foot center was evacuated, he added. 1858
TWIN LAKES, Colo. -- Riley Tinkham has done something very special with his dad's prized Porsche.He inherited the 1982 model when his father, Richard, died of complications from cancer in 2016. The car had been sitting in a garage for several years, so Tinkham fixed it up.Earlier this summer he took the car and parked it in front of his house in Twin Lakes, Colorado. He adorned it with a couple of inspirational quotes, one on each side of the Porsche.He borrowed one of them from Mark Twain."Twenty years from now you will be more disappointed by the things that you didn't do than by the ones you did do. So throw off the bowlines. Sail away from the safe harbor. Catch the trade winds in your sails. Explore. Dream. Discover."He said the second quote is from Billy Cox, a motivational speaker."Life will only change when you become more committed to your dreams than your comfort zone.""I think that's a really poignant quote today," Tinkham said, "with how many comforts we have in life, how much technology we have. Everything is easier than it's ever been."After seeing the quotes, Tinkham's friend, Bob Dalzell, who operates a coffee shop on wheels called Percolated Peaks, suggested that he leave a magic marker out for others to add their own inspiration.So he did."Not all who wander are lost," one woman wrote."Live life, have fun, kick ass," a man wrote."The mountains are calling and I must go," wrote another woman.Tinkham told KMGH he's enjoyed seeing the next level his car has gone to."I'm being inspired," he said. "To see that shared with other people is really rewarding." Tinkham said the orange paint is removable and he plans to peel it off in the spring and start a new project with the special car. 1789
Uncle Sam needs to borrow a ton of money this week — in the middle of a fight with its biggest creditor.The United States plans to sell about 4 billion of debt, according to the Treasury Department. That's the highest for a week since the record set during the 2008 financial crisis.Federal revenue is declining because of President Trump's tax cuts, so the government needs to borrow more to make ends meet. At the same time, Washington's borrowing costs have climbed rapidly in recent months. 505
Tuition bills are coming due, and while millions of students across the country are weighing the risks of going back to college in the middle of a pandemic, the most financially strapped students carry an added burden of dwindling aid.For Americans living in the lowest income brackets, college represents a way up the socioeconomic ladder. But getting there and obtaining a degree is not easy, especially for students without financial means. The Pell Grant has historically removed some of the obstacles for the most at-need students. But alongside the skyrocketing cost of higher education, the federal grant is having less and less of an impact.The Pell Grant is the largest source of postsecondary education grant aid, helping to fund higher education for at-need students since 1973. In its budget proposal for the 2020-21 school year, the U.S. Department of Education anticipated giving Pell Grants to 6.8 million at-need students, to the tune of .6 billion.How much each student qualifies for depends on their expected family contribution, or how much the federal government says they should be able to contribute toward their own education. Those with the most financial need could qualify for the maximum allowable grant amount: ,345 in the 2020-21 academic year.That authorized maximum amount has grown from ,400 in the Pell Grant’s early years. Despite this growth, it has failed to keep pace with the ballooning costs of a college education.In the past 20 years, average tuition and fees at public four-year institutions (the most affordable type conferring bachelor degrees) have more than doubled, to ,440, while maximum Pell Grant awards have only grown 29%. And tuition isn’t everything — room and board, books and living expenses come at an additional cost.As recently as 2002, the most at-need students would nearly be able to cover their entire tuition and fees at these lower-cost institutions by qualifying for the maximum Pell Grant. But now, those qualifying for maximum Pell awards would find it covers just 59%.Not only has the Pell Grant not kept pace with college costs, it hasn’t kept pace with inflation. To have the same buying power as ,400 did in the grant’s early days, the maximum award amount would need to be about ,000 today.Loans likely filling the funding gapAccording to data from the most recent National Postsecondary Student Aid Study, 90% of dependent full-time undergraduates from households in the lowest income quartile received a Pell Grant in 2016. Among independent undergraduates in that income bracket, 64% received the grant.State and institutional need-based grants may be picking up some of the slack. State need-based grants went to 27% of all full-time students at public four-year institutions in 2016. Need-based grants from institutions went to 17%. But some 57% of students in this lowest income group took out student loans that year.While the Pell Grant typically accounted for 34% of a low-income undergraduate’s total aid in 2016, loans accounted for 44%.Gone are the days when a student’s job (or jobs) could cover their college costs. When grants and scholarships — free money — aren’t enough to cover the costs of education, those from households without college savings have little choice but to turn to borrowing. But student loan debt can be detrimental to lower-income students. A degree can confer higher earning potential, but for a variety of reasons — some of them financial — students in the lowest income brackets are typically the least likely to graduate, according to data from the U.S. Department of Education.Low-income parents also feeling the stingWhen a dependent student has exhausted grants and federal loan limits themselves, they can tap their parents’ borrowing potential.Parent PLUS loans have been around since 1980, allowing parents to borrow up to the difference between the entire cost of attendance and the aid directly awarded to their student. Borrowers must pass a credit check, but there are no income requirements. As of the second quarter of 2020, these loans account for billion or over 6% of all federal student loans outstanding, according to the Department of Education.In 2016, 11% of dependent full-time students in the lowest income quartile at public four-year institutions benefited from federal parent PLUS loans, according to the NPSAS. That’s compared to just 3% in 1996. These loans typically amounted to ,500 in 2016.Federal PLUS loans come with higher interest rates and fewer repayment options than federal student loans. In the 2020-21 school year, PLUS loans are being offered at 5.3% interest compared with 2.75% for federal undergraduate loans. And should a parent run into difficulties repaying the loans — as they increasingly do, according to an analysis from the Brookings Institution — there is only one income-driven plan available. Income-Contingent Repayment plans lower monthly payments by capping them at a percentage of income, but increase the total amount paid over the life of the loan due to interest and an increased term length.What students can doBarring significant increases in need-based aid or significant decreases in college costs, lower-income students and their parents will often have to continue cobbling together their college funds from a variety of sources.The following tips are applicable for anyone who doesn’t have their entire cost of college covered:Maximize free money. Fill out the Free Application for Federal Student Aid, or FAFSA, on time — every year. It’s how you access federal, state and institutional financial aid. Apply for scholarships every year, and only turn to loans when free money is exhausted.Be strategic about borrowing. Borrow only what’s needed and opt for federal student loans whenever possible. Carefully weigh the risks of borrowing a parent PLUS loan versus a private student loan, should education expenses exceed what you can qualify for.Compare costs across institutions. Don’t commit too quickly — weigh all costs associated with attending various schools, and consider starting your college career at a lower-cost community college.Earn while you learn. Look into the work-study program or a part-time job to earn money while in school.Stay committed. Seek out resources on and off campus to stay engaged and enrolled. Leaving college without the increased earning power of a degree makes student loan debt that much harder to pay off.More From NerdWalletHow a Gap Year Might Haunt You FinanciallyDon’t Wait to Refinance These Student Loans‘Shadow’ Lenders Can Leave College Students in the DarkElizabeth Renter is a writer at NerdWallet. Email: elizabeth@nerdwallet.com. Twitter: @elizabethrenter. 6721