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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

UNITED NATIONS, Nov. 1 (Xinhua) -- China on Tuesday urged the International Atomic Energy Agency (IAEA) to further strengthen its leading role in enhancing global nuclear safety and promoting relevant international cooperation.Wang Min, Chinese deputy representative to the United Nations, made the remarks at an open meeting of the 66th session of UN General Assembly on the IAEA report.IAEA shoulders important responsibilities in promoting peaceful uses of nuclear energy and preventing nuclear proliferation, Wang said, adding that it needs to further summarize experiences and lessons of the Fukushima nuclear accident, assisting member states to enhance nuclear safety and emergency response capabilities.Wang urged the IAEA to "increase technical assistance to developing countries, improve newcomer's national nuclear infrastructure and promote the safe, secure and sustainable development of nuclear energy."The IAEA was also asked to strengthen nuclear safeguards regime, effectively prevent nuclear proliferation, and maintain an objective and impartial stand on sensitive and hot nuclear issues.China has always adhered to the principle of "safety first", he said. "China has established a rather comprehensive legal and standards system on nuclear safety, put in place an independent and effective supervision and regulatory framework, set up a comprehensive emergency response mechanism, and keep a good safety record in general."China has decided to contribute 200,000 U.S. dollars to the Nuclear Security Fund of the IAEA for the purpose of enhancing nuclear security capability of the Asia-Pacific Region, Wang added.

WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

HONOLULU, United States, Nov. 13 (Xinhua) -- Chinese President Hu Jintao and leaders of other Asia-Pacific Economic Cooperation (APEC) members met in Honolulu, Hawaii, Sunday to find ways to speed up regional economic integration, free trade and investment, and economic and technological cooperation.The annual meeting, hosted by U.S. President Barack Obama in his home state, is being convened at the JW Marriott Ihilani, Honolulu, to boost regional economic integration, trade, green growth, job creation in green industries, energy security, and regulatory cooperation.President Hu is expected to speak at the meeting. He will introduce China's stand on the topics and call for "improving global economic governance, shifting the growth methods, promoting economic globalization and regional economic integration," according to Chinese diplomats.Hu will join other APEC leaders in meeting with the APEC Business Advisory Council (ABAC), which presents recommendations to APEC leaders in an annual dialogue and advises APEC officials on business sector priorities and concerns.During this year's dialogue, APEC leaders are expected to discuss regional economic integrity, the development of small- and medium-sized enterprises, food security and other issues with ABAC representatives.This year's APEC meeting convenes at a time when the global economic recovery is fraught with instability and uncertainty, and encounters growing risks and challenges.Some major economies are experiencing an economic slowdown, while in the eurozone, sovereign debt risks are rising in some countries. High inflationary pressure is a problem in emerging economies, including some in the Asia-Pacific region. Protectionism in various forms is mounting.In face of the challenges, the APEC leaders will look for effective measures to stimulate the global economy, regional economic integration, free trade and investment, and economic and technological cooperation.China hopes the APEC members will implement the economic growth strategy agreed on last year, striving to achieve a balanced, inclusive, sustainable, innovative and safe economic growth, said Wu Hailong, assistant foreign minister of China, at a press briefing last week.He said that China expects the APEC members to comprehensively promote regional trade and investment liberalization, adding that all members should fulfill their commitments and oppose all forms of trade protectionism.APEC should strengthen economic and technical cooperation to enhance the ability of the developing members to develop further, and therefore to achieve common prosperity, said the senior diplomat."APEC members generally hold positive attitudes toward U.S. proposals in various fields such as green growth, innovation policy. But some of the U.S.'s expected outcomes are beyond the capacity of the developing members, and they have expressed their difficulties and concerns," Wu said.

WASHINGTON, Nov. 16 (Xinhua) -- Data from NASA's Galileo spacecraft have provided scientists evidence of what appears to be a body of liquid water, equal in volume to the North American Great Lakes, beneath the icy surface of Jupiter's moon, Europa, the U.S. space agency announced Wednesday.The data suggest there is significant exchange between Europa's icy shell and the ocean beneath. This information could bolster arguments that Europa's global subsurface ocean represents a potential habitat for life elsewhere in our solar system. The findings will be published Thursday in the scientific journal Nature.Europa, which is slightly smaller than Earth's moon, is believed to have a large ocean of salty water deep beneath its frozen crust. Galileo spacecraft, launched by the space shuttle Atlantis in 1989, studied Jupiter, which is the most massive planet in the solar system, and some of its many moons.Pictures of it sent back by Galileo point to a tortured surface of cracks and jumbled ice. Seeking to understand how such weird topography evolved in a place with such dim sunlight, scientists believe that the answer lies in similar processes on Earth.Their model suggests that Europa's ice shell is about 10 kilometers thick and within it are giant pockets of water, lying at depths as shallow as three kilometers. Warm water from these sub-surface lakes wells up in plumes, causing the ice to become brittle, crack and then collapse. The ice turnover would be a plus for the prospects for life, as it would transfer energy and nutrients between the sub-glacial lake and the surface."One opinion in the scientific community has been if the ice shell is thick, that's bad for biology. That might mean the surface isn't communicating with the underlying ocean," said Britney Schmidt, lead author of the paper and postdoctoral fellow at the Institute for Geophysics, University of Texas at Austin. " Now, we see evidence that it's a thick ice shell that can mix vigorously and new evidence for giant shallow lakes. That could make Europa and its ocean more habitable.""The data opens up some compelling possibilities," said Mary Voytek, director of NASA's Astrobiology Program. "However, scientists worldwide will want to take a close look at this analysis and review the data before we can fully appreciate the implication of these results."