济南前列腺有啥危害(济南太敏感了怎么办了) (今日更新中)

SAN DIEGO (KGTV) — The county Medical Examiner has identified the second teenager killed after a car lost control on a Mission Valley freeway and crashed before bursting into flames last weekend.David Chavez, 15, was killed by blunt force trauma, thermal cause, and smoke inhalation according to the ME in the tragic crash on Jan. 18.Police say a car was speeding at about 3 a.m. on the westbound Interstate 8 ramp to southbound State Route 163 when the driver lost control and hit a guardrail, sending the car down an embankment where it a tree and caught fire.RELATED:Community helping family of teen killed in Mission Valley crashAt least 2 dead in fiery freeway crash in Mission ValleyAnother 15-year-old, identified as Gustavo Beltran, was also killed in the crash.The driver, a 17-year-old, was arrested by CHP on suspicion of DUI. Two other teens in the car are also battling significant injuries. None of their identities have been released by authorities. 972

SAN DIEGO (KGTV) -- The former Imperial Beach PTA president who’s accused of embezzling thousands of dollars has pleaded guilty. Kaitlyn Birchman was supposed to have a preliminary hearing Thursday morning, but she’d already pleaded guilty to forgery of a financial institute. She is set for sentencing on April 3. RELATED: Former Imperial Beach PTA president charged with embezzlementBirchman served as the PTA president at Imperial Beach Charter School from 2016 to 2018. During that time, prosecutors say she stole at least ,000 from school membership fees, book drives and holiday fairs. 603

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) — The holiday season will be bright and alive with the sounds of bands and cheers this season.Several parades will return to San Diego in the next month, from the traditional Mother Goose Parade in El Cajon to the seasonal wrap-up with the Holiday Bowl Parade.And in between, even more festive entertainment across the county, as floats, marching bands, vintage cars, and performers get communities excited for the holidays.RELATED:Skate away on one of San Diego's outdoor ice rinks this holiday seasonSan Diego holiday tree lightings to catch this seasonTurkey trots, holiday runs in San Diego this seasonNov. 2473rd annual Mother Goose Parade: El Cajon's annual Mother Goose Parade hits the streets at 1 p.m., following Main Street from El Cajon Blvd. to 1st Ave. Each "Chapter" of the parade brings several floats and bands down the parade route for onlookers, all leading up to Santa's arrival.Dec. 6Coronado Holiday Parade: Coronado rings in the holidays with their annual parade at 6 p.m., with festival floats and performers making their way down Orange Ave., bringing Santa to the town's Christmas tree for a special lighting ceremony.Dec. 7Chula Vista Starlight Parade: Chula Vista's Starlight Parade begins at 5 p.m., as Third Avenue hosts vintage cars, marching bands, dancers, and more to kick off the holiday season in the South Bay.Encinitas Holiday Parade: For the 62nd year, Encinitas will see thousands gather to watch cars, floats, and marching bands head down Coast Highway 101 during the Encinitas Holiday Parade at 5:30 p.m. This year's theme is "Encinitas on the Move!"Ocean Beach Holiday Parade: OB's holiday parade kicks off at 5:05 p.m. on Newport Ave. under this year's theme of "Miracle on Newport Ave.!" Floats will also compete in categories for best lights, unusual float, and OB spirit!Dec. 8North Park Toyland Parade: Holiday magic comes alive at 11 a.m. in North Park as their annual Toyland Parade brings a display of festival bands, floats, and cars down University Ave., between Utah and Iowa Streets.La Jolla Christmas Parade: La Jolla celebrates the magic of Christmas starting at 11 a.m. during their annual Christmas Parade, this year under the theme "Christmas on the Moon." The parade will travel down Girard Ave. and Prospect St.San Diego Bay Parade of Lights: Boats dressed in lights and colorful decorations will glide along the San Diego Bay Parade of Lights before thousands of onlookers beginning at 5 p.m. each night. This year’s theme will be Comic-Con on the Bay.Dec. 14Mission Bay Christmas Boat Parade of Lights: Dozens of boats in their best holiday decor will hit the waters of Mission Bay for their own special parade beginning at 6 p.m., traveling between Vacation and Fiesta Islands.Oceanside Harbor Parade of Lights: Oceanside has its own celebration of the holidays on the water, as their Parade of Lights brings boats dressed in colorful lights and decorations to the harbor beginning at 7 p.m.Dec. 15Gaslamp Holiday Pet Parade: Pooches and felines will deck the paws in the Gaslamp District, as the annual Holiday Pet Parade makes its way down Fifth Ave. under the Gaslamp archway starting at 2 p.m.San Diego Bay Parade of Lights: (Second running) Boats dressed in lights and colorful decorations will glide along the San Diego Bay Parade of Lights before thousands of onlookers beginning at 5 p.m. each night. This year’s theme will be Comic-Con on the Bay.Dec. 26San Diego Holiday Bowl Parade: America's largest balloon parade returns to San Diego, as the Holiday Bowl Parade invites more than 100,000 out to watch marching bands, floats, drill teams, and, of course, balloons starting at 10 a.m. 3685

SAN DIEGO (KGTV) - The coronavirus pandemic, combined with a recently enacted state law, has created a new problem along San Diego's streets and boardwalks.Business owners say they're being overrun by vendors who set up makeshift stores and crowd sidewalks and walkways, while also luring customers out of long-established businesses."It's pretty much a free-for-all," says David McDaniel, the owner of Paradise Cove near Crystal Pier. "Anybody can sell anything, anywhere."He's partially correct. A new state law, Senate Bill 946, went into effect in 2018. Passed by the legislature and signed by Gov. Jerry Brown, it decriminalizes street vending, telling cities that they can create their own guidelines and can only enforce them with tickets for vendors who violate the rules, instead of criminal charges.Several cities in San Diego County, including Carlsbad and Vista, were quick to establish their regulations. San Diego still hasn't.As more vendors set up shop, the Pacific Beach Town Council is asking city leaders to move the process along."We're calling on city leaders to end the swap meet on our boardwalks now," says Brian White, the President of the Pacific Beach Town Council. "We have lots of pedestrian traffic, bicycles, skateboards. There really is no room for this type of vending activity."Earlier this month, the Town Council sent a letter to Mayor Kevin Faulconer and the City Council asking for specific rules.The San Diego City Council started to establish new rules for vendors in 2019. Faulconer sent a draft ordinance to the Economic Development Committee.It would have prohibited vendors on the boardwalk and other high traffic areas. It also would require business permits, set hours for vending, establish distances from public facilities, require vendors to follow health and safety rules, and several other rules.That ordinance passed the committee unanimously on July 25, 2019.The city then held three public forums about it in October. But it never went to the full council for approval."It is an issue that's becoming a real problem. We definitely need to get some regulations going with this," says City Councilmember Jennifer Campbell, who represents Pacific Beach and Mission Beach."It's really up to the mayor's office to bring us these recommendations to City Council," says Campbell.ABC 10News reached out to Faulconer to see why there has been a delay in moving the draft ordinance forward. In a statement, Ashley Bailey, the mayor's Deputy Director of Communications, says, 2526

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