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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959

LOS ANGELES (CNS) - The Westfield Century City mall was evacuated Friday as police, firefighters and a bomb squad responded to a report of a manwith a gun and a fire inside a bookstore.Los Angeles Police Department officers responded to the facility in the 10000 block of Santa Monica Boulevard at about 12:45 p.m., according to department spokesman Sgt. Barry Montgomery.When they arrived, people were streaming from the mall and they set about trying to locate the suspect, Montgomery said.A security guard informed officers he hadn't heard any gunshots or located any victims, according to the sergeant.``While proceeding with their search, officers were directed to a suspicious package located inside the Amazon store,'' he said. ``In an abundance of caution (an) LAPD bomb squad and (the) Los Angeles Fire Department responded to the scene.''At about 2 p.m., smoke was seen coming from the roof of the Amazon store. Fire sprinklers were activated inside the store, according to news reports.No injuries or shots fired had been reported as of 3 p.m., police said. People in parts of the mall were evacuated, but those in other areas of the large facility were advised to shelter in place while officers conducted a search, LAPD Officer Tony Im said.Paul Almond, a Century City attorney, told City News Service he was having lunch at Toscanova in the mall when the restaurant manager said police had ordered him to evacuate the restaurant. At that point the manager told diners and workers to leave immediately.Almond said he walked out of the mall and was joined on the sidewalk by numerous other shoppers and diners who had also been ordered out. He then went to a building housing a bank on the east side of Avenue of the Stars, across the street from the mall, and found that building too had been locked down.At the H&M clothing store, employees and shoppers were ushered into a basement area where they holed up for about two hours before the LAPD lifted the shelter-in-place order around 2:35 p.m.According to a broadcast report, a person described as a male in his late teens who had a gun was seen on a security camera, but there were no reports of any arrests. 2186

LOS ANGELES (AP) — Members of the Trump administration visited Los Angeles Tuesday to get a firsthand look at the city's sprawling homeless encampments and efforts to control them, while President Donald Trump directed his staff to develop policy options to address the national crisis of people living on the streets.The visit by a delegation from several federal agencies came about two months after the Republican president called the homelessness crisis in Los Angeles, San Francisco and other big cities disgraceful and faulted the "liberal establishment" for the problem.In July, Democratic Mayor Eric Garcetti issued a public invitation for the Republican president to walk the streets with him and see the suffering and squalid conditions. The mayor released a letter to Trump on Tuesday saying he looked forward to working together, but tensions between the White House and officials in heavily Democratic California were also on vivid display.Gov. Gavin Newsom has sparred with the White House routinely, and his office released a statement Tuesday saying the state was ready to discuss serious proposals but Trump "could start by ending his plans to cut food stamps, gut health care for low-income people and scare immigrant families from accessing government services."San Francisco Mayor London Breed said in a statement that the city would welcome assistance from the federal government to build more housing "but simply cracking down on homelessness without providing the housing that people need is not a real solution."Garcetti, too, said he was ready to talk but wrote that "the federal government has woefully underfunded our housing safety net, contributing to homelessness" and slashed funding for new housing."We must put politics aside," he wrote.And at an event Monday in Beverly Hills, sponsored by the website Politico, Garcetti's chief of state and federal affairs, Breelyn Pete, said the city looked forward to explaining its homeless strategy to administration officials but added, "They're just not thoughtful, and quite frankly not smart enough, to know what we're doing."Trump would make an unlikely pairing with the Los Angeles mayor, who comes from a heavily Democratic state recognized as the center of the so-called Trump resistance. Trump lost California to Hillary Clinton in the 2016 election by over 4 million votes.White House spokesman Judd Deere echoed Trump's earlier remarks linking homelessness with liberal policies, saying "the president has taken notice of the homelessness crisis, particularly in cities and states where the liberal policies of overregulation, excessive taxation, and poor public service delivery are combining to dramatically increase poverty and public health risks."Like many big cities, Los Angeles has struggled with homelessness for decades, and the population on the streets has grown despite a robust economy. Filthy, drug-infested encampments line downtown streets, and homeless people often sprawl on the lawn of City Hall, with tents nearby. The mayor says 36,000 people in the city are homeless on any given night.Figures released in June showed a 16% jump in Los Angeles' homeless population over the last year. The jump came after the mayor helped convince voters in 2016 to borrow .2 billion to construct housing for the homeless.The mayor's office said the federal group visited several homelessness projects, including a recently opened shelter.On Tuesday, Sacramento County and the city of Sacramento joined the fight to overturn a federal court ruling barring municipalities from prosecuting homeless people for sleeping on the streets if there are no available shelter beds, The Sacramento Bee reported .The Trump administration provided no specifics on what its national homeless policy would entail.Taylor Griffin, a spokeswoman for House Speaker Nancy Pelosi, said, "Homelessness is a challenge to the conscience of our nation and a growing humanitarian crisis for communities across our country. The Trump Administration's heartless policies have only exacerbated the matter." 4077

Lorenza Marrujo is 67 years old and less than five feet tall — but she's no weakling.An intruder recently confronted Marrujo at her seniors apartment complex in Fontana, California. Not only did she protect herself, but her neighbors, too."As he was coming towards me, I said, 'back off.' Right away," Marrujo said.Marrujo has 26 years of martial arts training, so when she told the intruder to back off, he listened. Unfortunately, he made his way to the apartment of 81-year-old Elizabeth McCray — Marrujo's neighbor."He grabbed me and shook me, and I went down on the floor," McCray said.Marrujo heard McCray's screams and went to help."I squeezed myself between her and him. I put mama on the side, and I jumped on him, and I was punching him and everything," Marrujo said. "And I had the cane against his throat."Marrujo said she didn't want to kill him, so she held him down with her hands."He lifted up and tried to twist my hand. At the same time, I twisted his and turned it around real fast," Marrujo said. "And he was saying, 'you're hurting me, you're hurting me.' And I said, 'I don't care. I don't care what happens to you. You had no right to hurt an elderly person.'"McCray was stunned by her neighbor's bravery."I didn't expect that little lady would be that brave," she said. "I was trembling. I grabbed her by the leg. I said, 'could you be careful; you're gonna kill us.' She said, 'not tonight.'"Police later arrived on the scene and took the intruder into custody. Despite Marrujo's bravery, police say it's not a good idea to attack an intruder."We don't recommend you just jumping in," said Jennie Venzor, a spokesperson for the Fontana Police Department. "We recommend that you dial 911 for emergency assistance, which, in this case, she did that, and she also jumped in. What she told me is that her training kicked in, and it was like a muscle memory. She knew she had to help her friend out."McCray was taken to the hospital for treatment and released the next day. 2001

LONDON (AP) — Britain’s chief medical officers have raised the nation’s official COVID-19 alert level, meaning the virus is in general circulation and the transmission is high.The chief medical officers of England, Scotland, Wales and Northern Ireland say cases are rising “rapidly and probably exponentially.”They say they are acting on the advice of the Joint Biosecurity Center and raising the level from three to four, the second-highest level.Chief Scientific Officer Patrick Vallance warned that without further action, the U.K. could see 50,000 new coronavirus cases a day by mid-October, the BBC reports. He said that would likely lead to about 200 deaths per day.Chief Medical Officer Chris Whitty said infection rates are rising among all of the nation’s age groups and said it’s not acceptable for people to ignore health guidelines to engage in risky activity.British Prime Minister Boris Johnson is expected to announce further curbs Tuesday to slow the spread of the virus.Britain already has the worst virus death toll in Europe. 1052