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WASHINGTON, Dec. 7 (Xinhua) -- The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.Their report, published on-line Wednesday in Gynecologic Oncology, suggests that this combination, ixabepilone and sunitinib, might offer a much needed treatment option for women with advanced ovarian cancer.Neither drug is approved for use in ovarian cancer. Ixabepilone is a chemotherapy drug that, like other taxane drugs, targets the microtubules and stops dividing cells from forming a spindle. It has been approved for use in metastatic breast cancer. Sunitinib, approved for use in kidney cancer, belongs to a class of tyrosine kinase inhibitors that stops growth signals from reaching inside cancer cells.When caught at late stages, ovarian cancer is often fatal because it progressively stops responding to the chemotherapy drugs used to treat it."Women die from ovarian cancer because their tumors become resistant to chemotherapy, so a drug that might be able to reduce that resistance -- which may be what this combination of agents is doing -- would be a boon to treatment of this difficult cancer," says study coauthor Gerardo Colon-Otero.The finding also highlights the importance of the role of a molecule, RhoB, that the researchers say is activated by the drug duo. It might be a potential biomarker that may help identify patients who might benefit from such combination therapy, the researchers say.

SAN FRANCISCO, Dec. 13 (Xinhua) -- Apple is in talks to acquire Israeli fabless semiconductor maker Anobit for 400 million to 500 million U.S. dollars, U.S. media reported on Tuesday.Apple is likely interested in Herzliya Pituach, Israel-based Anobit for an exclusive access to its embedded flash controllers which can significantly boost memory performance of smartphones and tablet computers, said technology news site TechCrunch, citing Calcalist, an Israeli newspaper in Hebrew which first reported the possible acquisition.Apple already uses Anobit's technology in iPhone, iPad and the MacBook Air.If the deal works out, it could be Apple's largest acquisition ever, surpassing its 404 million-dollar purchase of NeXT in 1997.It could also become Apple's first acquisition in Israel and the first with Tim Cook as the chief executive officer of the company since its iconic leader Steve Jobs passed away in early October.

HELSINKI, Nov. 7 (Xinhua) -- A data leak was uncovered in Finland Saturday, in which personal details of around 16,000 people were uploaded onto a file-sharing website, according to Finnish media report on Monday.This act of sabotage is the largest ever of its kind in Finland. The data leak is being looked into by the Finnish National Bureau of Investigation.Anonymous Finland claimed on Monday responsibility for the publication of personal details of thousands of Finns. The group temporarily published a sample of information on 16,000 people as proof of the hack. The hack was motivated by an apparent desire to shame the Finnish government into improving data security.Finnish National Bureau of Investigation has not confirmed the claims that a loose group of hackers known as Anonymous was behind the data leak.The list that was put on the Internet contains the names, full social security numbers, addresses, telephone numbers, street addresses, and email addresses of the victims. Several upper secondary vocational education institutions are on the list, and some civil servants and students of the Police College of Finland are mentioned by name.Finnish police have confirmed that the names of some Finnish Defense Forces staff are on the list. Finnish Defense Forces found out that fewer than 10 of its employees are included, and has informed these people. The military said the leak did not pose a security threat.

HANOI, Oct. 25 (Xinhua) -- The hand-foot-mouth disease (HFMD) and dengue were on the rise across Vietnam, reported the Vietnam Preventive Medicine Administration (PMA) on Tuesday.As of Oct. 23, the country had more than 76,120 HFMD patients and 135 fatalities. The number of incidents has increased significantly over the last few weeks, with an average of 2,000-2, 500 new cases reported each week.Southern Ho Chi Minh City and Binh Duong, Long An and Quang Ngai were the most-hit localities, said the report.Meanwhile, dengue was also reported on the rise. In the first ten months of the year, there were more than 41,200 infected cases and 32 fatalities. Currently, an average of 2-3 cases a day were hospitalized by dengue infections, mainly from capital Hanoi.Epidemiologists said that the increase of HFMD and dengue was due to the lack of specialized medicine and preventive vaccines. In addition, complicated climate change, environment pollution and low awareness of the disease among the community have contributed to the spread of the diseases nationwide.

BEIJING, Jan. 23 (Xinhua) -- An online survey has revealed that Chinese people have a mixed opinion on Sunday's Spring Festival TV gala, the 30th of its kind since 1983, albeit many of them agree that there were innovations and improvements in it.As of 10:00 p.m. Monday, about 48 percent of some 71,000 respondents in the poll held by sina.com.cn, one of China's major portal websites, said they think the gala fall short of their expectations.Another 23 percent of them said they think the gala was just fine, and only 10 percent said it was splendid.The gala, an annual grand celebration broadcast by the China Central Television on the eve of the traditional Spring Festival, China's lunar New Year, is the most-watched TV event in the country."I can see the efforts of the gala staff, but it is still not good enough," said netizen "roam the life" at the Sina weibo, a popular Twitter-like microblogging website.At the Sina weibo website, the topic "grumble at the 2012 Spring Festival TV gala" has outnumbered others with over 64 million comments and become the hottest topic of Monday.Nonetheless, many people acknowledge the innovations and improvements in the gala.The gala made some attempts to take a more public-friendly approach by inviting some "grassroots" performers, such as farmer-singer Zhu Zhiwen, as well as cutting all commercials during the broadcast.A dance performance depicting a romance of peacocks and starring Yang Liping, a well-known dancer in China, is the most-followed topic at the gala's official weibo account, drawing over 3,500 comments.The audience was also impressed by a piano duet played by Li Yundi, first prize winner of the the 14th Frederic Chopin international piano competition, and Leehom Wang, a Chinese-American pop singer-songwriter.Moreover, about 59 percent of the online poll respondents said the stage design was quite cool."There are really many improvements in the gala, but it is absolutely difficult to please everyone," wrote weibo user "Wawamiaowaiwai."Unlike their elder generation, the young generation in China has more diversified options for entertainment, and it is of great challenge to attract them at the Spring Festival celebration, said Xia Xueluan, a professor of sociology with Peking University.

来源：资阳报