济南治疗男科医院哪好(济南念珠菌前列腺炎治疗) (今日更新中)

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) - As coronavirus cases climb, a cancer patient faces an excruciating choice: Risk the trips to San Diego for potentially life-saving treatment or not.He was the picture of health, but in 2014 at the age of 45, Bryce Olson was diagnosed with an aggressive, stage 4 prostate cancer."I couldn't believe it. No family history of prostate cancer. Exercised every day," said Olson.Various treatments have kept his cancer at bay, but eventually, it began to grow again. About 10 months ago, the Oregon man began a clinical trial at Moores Cancer Center at UCSD, including IV immunotherapy treatment."Pretty ecstatic ... I've had pretty good success on it, kept the cancer contained," said Olson.As part of the trial, he must fly in to San Diego for treatment every three weeks, a trip suddenly fraught with risk. "Uber to the airport. Being in the airport. Being in an airplane. Getting an Uber to the hospital in San Diego ... makes me super anxious. Makes me feel like I'm a sitting duck," said Olson.Six years of cancer drugs have left son's immune system compromised."Here's the irony. I may die of cancer in the mid term or long term, but I will probably die of COVID-19 if I get it," said Olson.Olson recently made the painful decision to postpone his cancer treatments in San Diego."If I can get through this crisis - maybe miss some of my therapy - maybe I let the tiger a little out of the cage a little bit on the cancer thing. I feel like I could maybe reel that guy back in, but if I die of COVID-19, it's over," said Olson.His decision is one many others with weakened immune systems are also facing, whether to make that trip to a hospital for treatment."Folks like me are faced with Sophie's choice. We either go in and get the treatment that will extend our lives ... But by doing so, we could catch a disease that could kill us today," said Olson.There are some hoops to go through, but his San Diego doctors may be able to get him his infusion at an Oregon hospital. Even if that happens, he's not sure he'd go, because of all the same concerns. 2081

SAN DIEGO (KGTV) - California Governor Gavin Newsom signed a State of Emergency Proclamation Friday clearing the way for firefighters to jump on projects meant to protect communities.Newsom said we're seeing larger and more dangerous wildfires than ever before and as a state we need to change our approach."Our world is changing, the wets are getting a lot wetter, the hots hotter and the dry, drier," he said.Alpine shared in the devastation last year; the West Fire leveled neighborhoods and left dozens homeless.CalFire Director Michael Mohler said ten crews across the state will be activated under the proclamation to clear brush and conduct controlled burns. They will also work with 110 members of the National Guard.The proclamation focuses on vulnerable communities. CalFire's Priority Fuel Reduction Project List includes two communities in San Diego County, Guatay and Crest. "Some of them have gone through some kind of environmental review," Director of the Sierra Club, Katheryn Phillips said.The U.S. Forest Service plans prescribed burns a year in advance to account for the environmental processes."We already know the areas of concern and we know how the fire is going to react to those areas, so we have a lot of biologists come in, a lot of fire experts come in and determine which areas are good for burning," Public Affairs Officer for Cleveland National Forest Olivia Walker said.Under the proclamation, environmental regulations are suspended, concerning environmentalists."If it's a butterfly mating season and it's an endangered species, it's not going to be the proper time to burn," Walker said."Could an unintended consequence be a mudslide?" Phillips added.Mohler said there's nothing to worry about, saying the proclamation solely streamlines the paperwork. He said they will absolutely bring in biologists, environmental scientists and archeologists before lighting prescribed burns."The good news is the governor is engaged in this issue I think the issue of how we deal with some of the impacts of climate change; this is just the beginning of a very long conversation," Phillips said. 2128

SAN DIEGO (KGTV) -- COVID-19 related hospitalizations continue to sure across California.Without any intervention, Gov. Gavin Newsom said current projections show hospitalizations could increase two to three times the current amount in just one month.“We’ve seen a significant increase, 89 percent increase over the 14-day period of people who have been hospitalized that have tested positive for COVID-19,” Newsom said during a press briefing Monday.Hospitalizations are rising in San Diego County, with local hospitals seeing more COVID-19 cases than they ever have.“We’re seeing about three times the number that we saw just a couple of months ago,” said Dr. Omar Khawaja, the Chief Medical Officer for Palomar Health. “About 25 percent of the positive patients are ending up in the ICU; that’s less than we saw during the first spike.”Khawaja said he expects more hospitalizations in the coming weeks as COVID-19 cases related to Thanksgiving gatherings start to show up.In Escondido, Palomar Medical Center has had room to handle more COVID-19 patients from other hospitals for several months now. A federal medical station is set up inside the hospital with 202 beds that haven’t been used yet.Khawaja said they’re now ready to take on patients from other hospitals across the county that become overwhelmed, but the set-up is not meant for ICU patients.“It could be beds that we would be offload some of the less sick patients from other systems into there so they can handle the sicker patients; we don’t have a solid plan for it yet,” he said. “I don’t think it’ll be activated in the next week; it may be three or four weeks out, so we’re planning for that now.”Khawaja said the details are actively being discussed with other medical officers across the county.“The county and hospital systems are all working very well together, collaborating, communicating on at least a weekly basis. We are actively discussing right now, what would it look like, how would we open it, and what type of patients would go into there,” he said. “Are we worried? Absolutely. Is the spike coming very quickly? Yes, but we do have some capacity and redundancy available now, and we are planning to have even more."Creating more capacity could include scaling back on the number of elective surgeries scheduled, but this time Khawaja said it would look much different than what we saw months ago.“What we’ve done is essentially looked at surgeries and classified them in terms of how long can this be put off to be safe, we all saw that JUST shutting everything down just let to really, just poor patient care, and we don’t want to do that again.” 2646

SAN DIEGO (KGTV) — Boulevard Fitness in University Heights has closed its doors following a letter from the city threatening expensive fines and to force the business to close.The gym stayed open in the face of local coronavirus-related restrictions on indoor activities for fitness centers for more than a month, according to a letter from City Attorney Mara Elliott."To date, evidence we have reviewed shows your business has been out of compliance for more than 45 days. If our office chooses to remedy the violation by pursuing an unfair business practices action, you and your business could be subject to fines of ,500 a day for each violation and orders to close," Elliott's letter on Tuesday stated.RELATED: Businesses to begin outdoor services at San Diego parksIn a letter sent to the gym's members on Wednesday, Boulevard Fitness said it has temporarily closed "due to current fiscal situations.""We are not sure when this closure period will end but we will be [sic] continuously monitor this and update you when appropriate," the gym's letter read. "However, we are working closely with our legal counsel to get in compliance with public health orders so that we can open up again soon."Boulevard Fitness owner Shawn Gilbert told ABC 10News back in July that staying open is a matter of survival."I took a huge financial hit in May. Money out of my pocket that's never coming back. We have bills to pay, we have rent to pay,” Gilbert told ABC 10News. He added that he believed his gym can operate indoors safely with face coverings and distancing, and that he has an outdoor area he plans to utilize.The gym on El Cajon Boulevard had been limiting the number of people inside and increasing cleaning and other measures to try to limit the risk of spreading the virus.RELATED: North Park gym forced to move outside, immediately finds syringeThis month, ABC 10News analyzed data from 211 revealed the gym was among businesses that have received the most complaints from the public about health order violations, with 141 complaints at the time.In a follow-up to ABC 10News, Elliott said the gym was contacted several times by San Diego Police officers and given warnings and citations by the county. This is reportedly the first case of its kind referred to the City Attorney's office."For more than a month, Boulevard Fitness ignored the county's orders to stop endangering the health of its members and the public. My office stepped in and got quick compliance the same way we did with the Banker's Hill party house -- by laying out the fines and penalties we could seek if they continued breaking the law, " Elliott said. "The spread of COVID is a problem that my office takes seriously."San Diego County officials are still awaiting guidance on reopening from the state after the region was removed from the California Monitoring List last week. 2870

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