济南疾病男科(济南前列腺特异抗原检查) (今日更新中)

WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

SAN FRANCISCO, Dec. 9 (Xinhua) -- Apple on Friday suffered a major setback in its global patent war, as a German court ruled over its copyright infringement battle in favor of Motorola Mobility.The German court ruled that Apple's iPhone and iPad infringe a Motorola patent and issued an injunction banning the import of iPhones and 3G-capable iPads into Germany.The dispute, one of Apple's several patent lawsuits around the world, is over a Motorola patent essential to GPRS. Motorola has been negotiating with Apple over licensing terms and conditions since 2007, and it will continue its efforts to resolve its global patent dispute as soon as practicable, said Motorola Mobility in a statement on Friday."We're going to appeal the court's ruling right away. Holiday shoppers in Germany should have no problem finding the iPad or iPhone they want," an Apple spokesman told tech news site AllThingsD.Apple is not too concerned about losing out in the Christmas shopping season as it has plenty of iPhones and iPads in Germany already, AllThingsD cited unidentified sources as saying.The ruling is against Apple's European sales company and only impacts its products sold in Germany. The German court also ruled that Motorola is entitled to a damages award.Apple can appeal the ruling to a higher court and request a stay of the injunction, according to a blog post of Florian Mueller, a U.S. patent expert who has been closely following patent lawsuits in the mobile industry.Mueller said should Apple make the appeal but the court declines the stay, Motorola must post a 100 million euro (around 134 million U.S. dollars) bond before the court will enforce the injunction.In August, Apple also filed a suit in Germany over the design of Motorola's tablet Xoom, which runs Google's Android system. But Apple did not make it clear whether it will seek to block the sales of Xoom in Europe.Also on Friday, Samsung won an appeal from the Australian High Court overturning a previous Apple victory that effectively banned Samsung from selling its Galaxy Tab in Australia.Based on claims of infringing Apple's patents, the Cupertino, California-based tech giant has been seeking court order to block Samsung's Galaxy line of mobile devices around the world.A German court issued an injunction in August, blocking Samsung from selling its Galaxy Tab 10.1 tablets across all European Union members, except for the Netherlands.On Thursday, Apple said it will appeal a San Jose, California judge's refusal to ban sales of Samsung 4G smartphones and Galaxy Tab 10.1 tablets in the United States.

QINGDAO, Shandong, Dec. 26 (Xinhua) -- China's largest rail vehicle maker, CSR Corp. Ltd, over the weekend launched its first test train that features speeds reaching up to 500 km per hour.The six-car train with a fairshaped head is the newest in the CRH series. It has a maximum tractive power of 22,800 kilowatts, compared with 9,600 kilowatts for the CRH380 trains currently in service on the Beijing-Shanghai High-Speed Railway, which hold the world speed record of 300 km per hour.The grey-color train carrying testing and data processing facilities was designed and produced by CSR Sifang Locomotive & Rolling Stock Co., Ltd (Sifang Locomotive), a CSR subsidiary based in the coastal city of Qingdao in eastern Shandong province.Ding Sansan, the company's chief technician, said the concept of the the super-speed train design was inspired by China's ancient sword. The bodywork uses plastic materials reinforced with carbon fiber.Shen Zhiyun, a locomotive expert and academician with both the Chinese academies of sciences and engineering, said the testing of the super-speed train with speeds of up to 500 km per hour will provide useful reference for current high-speed railway operations.

BEIJING, Jan. 05 (Xinhuanet) -- China's satellite television channels have aired fewer entertainment programs this year as broadcasting watchdog's curbs on "excessive entertainment" took effect.The State Administration of Radio, Film and Television has cut two-thirds of "racy" entertainment programs on China's 34 satellite channels since the campaign began, the spokesperson for the administration said on Tuesday.Since the regulation took effect on Jan 1, the total number of entertainment programs scheduled for prime-time -7:30 pm to 10 pm - broadcast a week dropped to 38 from 126 at the end of last year, according to a statement from the administration.Under the regulation, announced in October, each satellite channel can broadcast no more than two entertainment programs a week and the maximum length of the program may not exceed 90 minutes.The targeted programs, including dating shows, reality talent shows and emotional stories on the administration's list, were deemed "excessive entertainment" and showing "less taste"."Satellite channels should design programs with innovative content, promoting traditional virtues and socialist core values in their new entertainment programs," the authority said.The administration considers the move crucial to improving cultural content for the public by offering high-level programs.Meanwhile, the number of news programs on the satellite channels has grown to 193 a day, 33 percent more than in 2011.Currently, news programming on each satellite channel has surpassed two hours, and each channel has at least two 30-minute news programs during prime time.But popular dating shows such as If You Are the One, produced by Jiangsu Satellite TV, and reality shows such as China's Got Talent, aired by Shanghai-based Dragon TV, will remain on during prime time in the weekend.Li Hao, spokesman for Hunan Satellite TV, a broadcaster famous for its entertainment programs, told China Daily the regulation will improve the quality of entertainment programs."We have been exploring how to make entertainment shows more meaningful and valuable," he said, adding that the channel has shortened the length of its two entertainment programs from 110 to 90 minutes."We will supervise programs more strictly, and pay close attention to things such as the clothing and comments of hosts and guests," he added.Cheng Manli, a media professor at Peking University, welcomed the new regulation to limit "less tasteful" programs involving violence and money worship."After all, unhealthy programs may hurt young people who are not able to distinguish right from wrong, which also worries their parents," she said.However, Yu Guoming, a professor at the School of Journalism at Renmin University of China, did not think the regulation was the way to improve cultural development."Whether the entertainment program is good or not should be decided by viewers' reaction, instead of an administration's evaluation," he said. "Residents are under pressure and need to watch shows to relax in our society."Yu also said that a good entertainment program should respect residents' taste and give them more viewing choices, or else it could lead to rigid restrictions.Ma Yuqiang, who runs an online clothing retail company, said the new rule will not affect his daily life, because he can watch the entertainment programs that were taken off prime time on the Internet."I think the regulation will drive most young people to the Internet," Ma, 26, said.

BEIJING, Jan. 26 (Xinhua) -- China will firmly stand together with African countries while unswervingly pushing forward Sino-African strategic partnership, no matter how the international environment changes, said Chinese Vice Foreign Minister Zhai Jun Thursday.Zhai made the remarks in a signed article on top Chinese political advisor Jia Qinglin's upcoming visit to Africa.Africa still faced enormous challenges against the backdrop of simmering global finance crisis, and turbulence encountered by several countries in western Asia and northern Africa, which dealt a blow to Africa's peace, stability and development, Zhai said, adding that some outside forces' intervention into Africa's internal affairs impeded the integration process among African countries.Within this context, there is stronger demand of African countries for stability, development, solidarity and independence, he said.The international community should pay more attention to Africa's voice and problems, respect its opinions, accommodate its concerns, protect peace, stability and development in Africa, and support Africa's independent settlement of issues in its own region, Zhai said.He said Jia's visit, first foreign trip paid by Chinese leaders in the Chinese Lunar New Year, will be of great significance in deepening Sino-African ties and cementing the solidarity and cooperation among developing countries, Zhai said.Jia will declare China's determination on developing Sino-African ties during the trip, he said.Enhancing solidarity and cooperation with Africa constitutes an important part of China's diplomacy, and will be the long-term strategic choice firmly pursued by China, Zhai said.

来源：资阳报